ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1657910
This article is part of the Research TopicNeuroinflammation: Mechanisms and Therapeutic InterventionsView all 18 articles
Coixol ameliorates dopaminergic neurodegeneration through inhibiting neuroinflammation and protecting mitochondrial function
Provisionally accepted
Shuo YangJiaxi HanMiao XueYiming ZhangAohan YanXiyu GaoJiangmei HeXiaojia Sun
Dianfeng Liu
Bingxu Huang*- Jilin University, Changchun, China
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An enormous amount of research revealed that neuroinflammation played an important role in Parkinson's disease (PD). Coixol, extracted from Coix lacryma-jobi L., has anti-inflammatory and antioxidant effect on various diseases. However, the effect of Coixol on PD is unclear. The aim of the study is to explore the effect of Coixol on MPTP-injected PD mice model. Our results showed that Coixol improved the motor dysfunction and neuronal damage of PD mice via inhibiting neuroinflammation and maintaining mitochondrial function. And Coixol suppressed over-activated NF-κB and MAPK signaling pathways, and regulated NLRP3/Caspase1/IL-1β signaling pathway to inhibit neuroinflammation in PD mice. Results showed that Coixol relieved ROS-elicited mitochondrial damage to inhibit over-activated NLRP3 inflammasome. Taken together, we found that Coixol alleviated dopaminergic neurodegeneration in PD mice via inhibiting the activation of NF-κB and MAPK signaling pathways to suppress neuroinflammation, and protecting mitochondrial function from ROS production to regulate activation of NLRP3 inflammasome.
Keywords: coixol, Neuroinflammation, NLRP3, Mitochondrial dysfunction, Parkinson's disease
Received: 03 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Yang, Han, Xue, Zhang, Yan, Gao, He, Sun, Liu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bingxu Huang, Jilin University, Changchun, China
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