Structure Based Drug Discovery | List of Frontiers open access articles

Original Research

Accepted on 13 Oct 2025

Metabolic Engineering of Yarrowia lipolytica for Enhanced Microbial Production of Medium-Chain α, ω-Diols from Alkanes via CRISPR-Cas9 Mediated Pathway Optimization and P450 Alkane monooxygenase Overexpression

in Synthetic Biology

Ye Chan Kim
Yoon Hwan Choi Won
Eun-Jung Kim
Byung-Gee Kim
Hyungdon Yun

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1695661

Original Research

Accepted on 13 Oct 2025

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors

in Multiple Sclerosis and Neuroimmunology

Philipp M K Wolf
Dominik Hanke
Vijay Singh
Hanno L Keller
Luca J Ettischer
Laura Teppe
Anca-Laura Amati
Andreas Hecker
Faeq Husain-Syed
Marius Rohde

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661114

Perspective

Accepted on 13 Oct 2025

Rethinking the Bland-Altman plot when quantifying Virtual Coronary Physiology

in Coronary Artery Disease

Daniel Taylor
Harry Saxton
Ian Halliday
Julian Gunn
Paul D Morris

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1687923

Review

Accepted on 13 Oct 2025

Post-Transcriptional Regulation by HuR in Colorectal Cancer: Impacts on Tumor Progression and Therapeutic Strategies

in Cancer Immunity and Immunotherapy

Yilin Shi
Zhen Zhou
Cong Liu
Jing Liu
Mengying Xie
Xin Chen
Dan A Dixon
Xiaoqing Wu
Lingling Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658526

Original Research

Accepted on 13 Oct 2025

Predictive Value of Dual-Energy CT Assessment of Extracellular Volume Fraction on Efficacy of Immune Checkpoint Inhibitors in Patients with Liver Cancer

in Cancer Genetics

Lixing Lei
Xiao-hua Huang
Lingling Tang
Nian Liu
Ke Pan
Liu Qianqian

Frontiers in Oncology

doi 10.3389/fonc.2025.1659545

Correction

Accepted on 13 Oct 2025

Correction: The impact of Multi-Cycle Water Invasion on Underground Gas Storages and its Controlling Factors

in Structural Geology and Tectonics

Wei Liao
Shijie Zhang
Mingyang Lv
Yifeng Zhao
Huilin Yan
Guoliang Shi
Mohammad Nooraiepour
Lin Ma
Mikhail Spasennykh
Zezhang Song

Frontiers in Earth Science

doi 10.3389/feart.2025.1717287

Original Research

Accepted on 13 Oct 2025

Integrating scRNA-seq and Machine Learning Identifies MNAT1 as a Therapeutic Target in OSCC

in Cancer Immunity and Immunotherapy

Han Gao
Lehua Liu
Weixiang Qian
Yanfei Wu
Jiayao Wang
Weiping Yang
Yinfang Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663487

Systematic Review

Accepted on 13 Oct 2025

The efficacy of kinesiology tape for rotator cuff injuries: A meta-analysis of randomized trials

in Family Medicine and Primary Care

Yuan Luo
Liyue Zhang
Zhongbao Tang
Li Chen
Dingfan Zhou
Haiyan Huang

Frontiers in Medicine

doi 10.3389/fmed.2025.1695350

Original Research

Accepted on 13 Oct 2025

The association between nutritional assessment tools and CT-assessed sarcopenia in abdominal aortic aneurysm: a cross-sectional study

in Clinical Nutrition

Jiashu Yao
Yepeng Zhang
Wenqing Chen
Xiangrui Li
Guangyan Wu
Jie Wang
Xiaotian Chen
Bo Gao
Min Zhou

Frontiers in Nutrition

doi 10.3389/fnut.2025.1679038

Study Protocol

Accepted on 13 Oct 2025

An exploratory single arm study to evaluate the role of an Ayurvedic treatment protocol as a prerequisite for in vitro fertilization in women with Diminished Ovarian Reserve incorporating multi-omics approaches: Study protocol

in Family Medicine and Primary Care

Anjaly Muraleedharan
Muralidharan Vanuopadath
Avani Pillai
Bipin G Nair
Hemavathi Shivapura Krishnarajabhatt
Chithra Ramachandran

Frontiers in Medicine

doi 10.3389/fmed.2025.1666888

Systematic Review

Accepted on 13 Oct 2025

Multiple views, sobering outcomes: A systematic review on the participation of children with disabilities in early childhood education and care

in Special Educational Needs

Janina Dott
Ulla Licandro

Frontiers in Education

doi 10.3389/feduc.2025.1666615

Original Research

Accepted on 13 Oct 2025

A network analysis of the relationship between perceived social support, emotion regulation, and Job Burnout among elementary and middle school teachers

in Organizational Psychology

Tianci Wang
Yuyang Nie
Tianci Wang
Cong Liu
Yuxian Cao
Guofeng Qu
Lijia Hou
Kangli Du
Ming Ming Guo
Yueyao Li

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1704862

Review

Accepted on 13 Oct 2025

Systematic Review: Xenopus laevis as a Model for Ophthalmic Development and Disease Research

in Ophthalmology

Qiaoyu Li
Yun Feng
Xuechen Zhu

Frontiers in Medicine

doi 10.3389/fmed.2025.1545958

Original Research

Accepted on 13 Oct 2025

Laxity index measurement on stress radiographs obtained with the Vezzoni-modified Badertscher distension device technique: repeatability and reproducibility in a large cohort of dogs

in Veterinary Imaging

Sara Sassaroli
Francesco Gallorini
Francesco Roggiolani
Alberto Salvaggio
Rosario Vallefuoco
Andrea Pratesi
Mario Fordellone
Elisa Campagnoli
Angela Palumbo Piccionello

Frontiers in Veterinary Science

doi 10.3389/fvets.2025.1675958

Original Research

Accepted on 13 Oct 2025

Green transformational leadership and financial performance in micro and small enterprises: The interplay of circular economy practices and environmental uncertainty

in Circular Economy

Amelia Oktrivina
La Ode Sumail
Hendryadi Hendryadi
Syahrul Effendi
Harry Budiantoro

Frontiers in Sustainability

doi 10.3389/frsus.2025.1684185

158 views

Original Research

Accepted on 13 Oct 2025

Rotational vs. Laser Atherectomy in Chinese CTO-PCI: Lesion-Specific Efficacy with Comparable Midterm Safety

in Atherosclerosis and Vascular Medicine

Liansheng Chen
Zehan Huang
Quanmin Wu
Huiliang Deng
Meiping Huang
Yiqi Xu
Jinkun Wei
Yong Liu
Nianjin Xie
Yuming Huang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1650595

Articles

Metabolic Engineering of Yarrowia lipolytica for Enhanced Microbial Production of Medium-Chain α, ω-Diols from Alkanes via CRISPR-Cas9 Mediated Pathway Optimization and P450 Alkane monooxygenase Overexpression

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors

Rethinking the Bland-Altman plot when quantifying Virtual Coronary Physiology

Post-Transcriptional Regulation by HuR in Colorectal Cancer: Impacts on Tumor Progression and Therapeutic Strategies

Predictive Value of Dual-Energy CT Assessment of Extracellular Volume Fraction on Efficacy of Immune Checkpoint Inhibitors in Patients with Liver Cancer

Correction: The impact of Multi-Cycle Water Invasion on Underground Gas Storages and its Controlling Factors

Integrating scRNA-seq and Machine Learning Identifies MNAT1 as a Therapeutic Target in OSCC

The efficacy of kinesiology tape for rotator cuff injuries: A meta-analysis of randomized trials

The association between nutritional assessment tools and CT-assessed sarcopenia in abdominal aortic aneurysm: a cross-sectional study

An exploratory single arm study to evaluate the role of an Ayurvedic treatment protocol as a prerequisite for in vitro fertilization in women with Diminished Ovarian Reserve incorporating multi-omics approaches: Study protocol

Multiple views, sobering outcomes: A systematic review on the participation of children with disabilities in early childhood education and care

A network analysis of the relationship between perceived social support, emotion regulation, and Job Burnout among elementary and middle school teachers

Systematic Review: Xenopus laevis as a Model for Ophthalmic Development and Disease Research

Laxity index measurement on stress radiographs obtained with the Vezzoni-modified Badertscher distension device technique: repeatability and reproducibility in a large cohort of dogs

Green transformational leadership and financial performance in micro and small enterprises: The interplay of circular economy practices and environmental uncertainty

Rotational vs. Laser Atherectomy in Chinese CTO-PCI: Lesion-Specific Efficacy with Comparable Midterm Safety