Systems Biology Research | List of Frontiers open access articles

Original Research

Accepted on 23 Oct 2025

Identification of glycolysis-related clusters and immune cell infiltration in hepatic fibrosis progression using machine learning models and experimental validation

in Inflammation

Guanglin Xiao
Zhiling Deng
Ke Qiu
Aoyi Li
Xingyue Yi
Hong Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684937

Original Research

Accepted on 23 Oct 2025

Combination therapy improves survival prognosis in anti-MDA5-antibody-positive dermatomyositis patients: a single-center retrospective study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Congcong Gao
Gaohui Wei
Chaoying Li
Chunyi Zhang
Chenqiong Wang
Ruxu Li
Kebing Shen
Zhaohui Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658547

Brief Research Report

Accepted on 23 Oct 2025

Potential Activity of Pleurotus nebrodensis Mushroom Extract against Biofilm of Meticillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

in One Health in Bacteriology

Maria Letizia Gargano
Ilenia Cicero
FORTUNATO CIRLINCIONE
Anna Giammanco
Virginia Talarico
Ignazio Arrigo
Teresa Maria Assunta Fasciana

Frontiers in Bacteriology

doi 10.3389/fbrio.2025.1697820

Policy and Practice Reviews

Accepted on 23 Oct 2025

Top-Down Pressure and Bottom-Up Responses: A Study on Provincial Governments' Adoption and Textual Reproduction of Sports Industry Policies in China

in Sports Politics, Policy and Law

Zhiliang Li
Jingjing Zhou
Jian Liu

Frontiers in Sports and Active Living

doi 10.3389/fspor.2025.1665567

Original Research

Accepted on 23 Oct 2025

Effects of moderate to vigorous physical activity on the associations of insulin resistance surrogate with incident cardiovascular disease and all-cause mortality: a cohort study from the UK Biobank

in Cardiovascular Endocrinology

Ying Zhu
Tianci Yao
Hongyu Yan
Qinmei Ke

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1709135

Original Research

Accepted on 23 Oct 2025

PSCP, a Novel Reactive Sulfur Donor, Activates Keap1-Nrf2 Signaling and Attenuates Mitochondrial Dysfunction in Diabetic Retinopathy

in Diabetes: Molecular Mechanisms

Kexin Li
Ruiying Ji
Youbang Chen
Yiwen Wang
Yiyan Guo
Xiang Li
Hui Zhang
Zaopeng He
Liang Guo
Chuntao Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1690553

Original Research

Accepted on 23 Oct 2025

Acceptance of a Net Zero Urban Water Future: Challenges and Strategies for a Sociotechnical Shift of Water Systems

in Water and Built Environment

Courtney Crosson
Stephanie Pincetl
Rashi Bhushan
Caroline Scruggs
Adriana Zuniga-Teran
Neha Gupta
Erik Porse
Sybil Sharvelle
Dominic L Boccelli
Gregory Pierce

Frontiers in Water

doi 10.3389/frwa.2025.1637215

Original Research

Accepted on 23 Oct 2025

Screening for dual-target enzyme inhibitors derived from Gardenia jasminoides Roots, a medicinal and edible plant: Investigation of their potential anti-dementia activity

in Food Chemistry

Xuanlin Liu
Yang Zhou
Rui Meng
Jingyi Han
Ming Chen
Xiangjie Bo
Sainan Li
Daqian Song
Yuchi Zhang

Frontiers in Nutrition

doi 10.3389/fnut.2025.1682948

Original Research

Accepted on 23 Oct 2025

Comparative Efficacy and Safety of Botanical Drugs for Mild Cognitive Impairment: A Systematic Review and Network Meta-analysis

in Ethnopharmacology

Tao Wang
Yifan Yang
Haixia Wang
Yongmei Yan
Jianmeng Lü
Hui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657169

Original Research

Accepted on 23 Oct 2025

Anti-Ulcer Activity of Green synthesized Selenium Nanoparticles using Nigella Sativa L. Seed Extract in Rats

in Ethnopharmacology

Awatef ELWEJ
Fawziah Al-Otaibi
khadija Boukholda
Fahad Alminderej
Faez Alotaibi
Amani Kaabi
Nada M. Ali
Hamadi Fetoui
Kaiss Aouadi
Adel Kadri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638593

Original Research

Accepted on 23 Oct 2025

Differential effects of Huang-Lian-Jie-Du Decoction on Alzheimer's disease and normal rats

in Ethnopharmacology

Manru Xu
Yue Zhu
Jinxin Chen
Furong Zhong
Ruoli Wang
Jie Li
Mengyuan Qiao
Yiran Fan
Pan Ren
Mingqi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710919

Original Research

Accepted on 23 Oct 2025

Network Analysis of School Absence: Central Symptoms and Their Functions

in Interventions for Adolescent Mental Health

Katarina Alanko
David Heyne
Martin Lagerström
Martin Knollman

Frontiers in Child and Adolescent Psychiatry

doi 10.3389/frcha.2025.1625164

Original Research

Accepted on 23 Oct 2025

Managing reputation of trustworthiness in face-to-face communication

in Language Communication

Manfred Krifka

Frontiers in Communication

doi 10.3389/fcomm.2025.1688492

Review

Accepted on 23 Oct 2025

Structure and Function of the Blood–Brain Barrier in Perioperative Neurocognitive Disorders

in Neurodegeneration

Yipeng Su
Yiting Chen
Bingqi Zheng
Yiting Huang
Zhongxiao Liao
Xiaochun Zheng
Fei Gao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1690354

Methods

Accepted on 23 Oct 2025

Pre-Clinical Development of a Wireless Neural Interface System for Osseointegrated Prosthetic Control in sheep

in Neuroprosthetics

LUCAS Alan SEARS
Ashlesha Deshmukh
Rishith Mereddy
Vinson Go
Brett Nemke
Yan Lu
Weifeng Zeng
Aaron J Suminski
Dr. Mark D. Markel
Kent Bachus

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1681136

Original Research

Accepted on 23 Oct 2025

Study on Global Properties of Brain Networks in Amnestic MCI Patients: Based on DTI and fMRI Data Analysis

in Brain Imaging Methods

Yingmei Han
Xue Bai
Weiqing Li
Ze Feng
Bingyuan Chu
Ming Yang
Qingqing shang
Hanxi Zhang
Xinlu Li
Feng Wang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1675610

Articles

Identification of glycolysis-related clusters and immune cell infiltration in hepatic fibrosis progression using machine learning models and experimental validation

Combination therapy improves survival prognosis in anti-MDA5-antibody-positive dermatomyositis patients: a single-center retrospective study

Potential Activity of Pleurotus nebrodensis Mushroom Extract against Biofilm of Meticillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

Top-Down Pressure and Bottom-Up Responses: A Study on Provincial Governments' Adoption and Textual Reproduction of Sports Industry Policies in China

Effects of moderate to vigorous physical activity on the associations of insulin resistance surrogate with incident cardiovascular disease and all-cause mortality: a cohort study from the UK Biobank

PSCP, a Novel Reactive Sulfur Donor, Activates Keap1-Nrf2 Signaling and Attenuates Mitochondrial Dysfunction in Diabetic Retinopathy

Acceptance of a Net Zero Urban Water Future: Challenges and Strategies for a Sociotechnical Shift of Water Systems

Screening for dual-target enzyme inhibitors derived from Gardenia jasminoides Roots, a medicinal and edible plant: Investigation of their potential anti-dementia activity

Comparative Efficacy and Safety of Botanical Drugs for Mild Cognitive Impairment: A Systematic Review and Network Meta-analysis

Anti-Ulcer Activity of Green synthesized Selenium Nanoparticles using Nigella Sativa L. Seed Extract in Rats

Differential effects of Huang-Lian-Jie-Du Decoction on Alzheimer's disease and normal rats

Network Analysis of School Absence: Central Symptoms and Their Functions

Managing reputation of trustworthiness in face-to-face communication

Structure and Function of the Blood–Brain Barrier in Perioperative Neurocognitive Disorders

Pre-Clinical Development of a Wireless Neural Interface System for Osseointegrated Prosthetic Control in sheep

Study on Global Properties of Brain Networks in Amnestic MCI Patients: Based on DTI and fMRI Data Analysis