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ORIGINAL RESEARCH article

Front. Health Serv., 05 April 2022
Sec. Cost and Resource Allocation
Volume 2 - 2022 | https://doi.org/10.3389/frhs.2022.786098

Socioeconomic Inequity in the Screening and Treatment of Hypertension in Kenya: Evidence From a National Survey

Robinson Oyando1,2* Edwine Barasa1,3 John E. Ataguba2,4
  • 1Health Economics Research Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya
  • 2Health Economics Unit, Faculty of Health Sciences, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
  • 3Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
  • 4Department of Community Health Sciences, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

Background: Non-communicable diseases (NCDs) account for 50% of hospitalisations and 55% of inpatient deaths in Kenya. Hypertension is one of the major NCDs in Kenya. Equitable access and utilisation of screening and treatment interventions are critical for reducing the burden of hypertension. This study assessed horizontal equity (equal treatment for equal need) in the screening and treatment for hypertension. It also decomposed socioeconomic inequalities in care use in Kenya.

Methods: Cross-sectional data from the 2015 NCDs risk factors STEPwise survey, covering 4,500 adults aged 18–69 years were analysed. Socioeconomic inequality was assessed using concentration curves and concentration indices (CI), and inequity by the horizontal inequity (HI) index. A positive (negative) CI or HI value suggests a pro-rich (pro-poor) inequality or inequity. Socioeconomic inequality in screening and treatment for hypertension was decomposed into contributions of need [age, sex, and body mass index (BMI)] and non-need (wealth status, education, exposure to media, employment, and area of residence) factors using a standard decomposition method.

Results: The need for hypertension screening was higher among poorer than wealthier socioeconomic groups (CI = −0.077; p < 0.05). However, wealthier groups needed hypertension treatment more than poorer groups (CI = 0.293; p <0.001). Inequity in the use of hypertension screening (HI = 0.185; p < 0.001) and treatment (HI = 0.095; p < 0.001) were significantly pro-rich. Need factors such as sex and BMI were the largest contributors to inequalities in the use of screening services. By contrast, non-need factors like the area of residence, wealth, and employment status mainly contributed to inequalities in the utilisation of treatment services.

Conclusion: Among other things, the use of hypertension screening and treatment services in Kenya should be according to need to realise the Sustainable Development Goals for NCDs. Specifically, efforts to attain equity in healthcare use for hypertension services should be multi-sectoral and focused on crucial inequity drivers such as regional disparities in care use, poverty and educational attainment. Also, concerted awareness campaigns are needed to increase the uptake of screening services for hypertension.

Introduction

Non-communicable disease-related morbidity and mortality pose an increasing challenge globally, especially in low-and middle-income countries (LMICs), where most of the world's population live (1). In 2016, for instance, ~40 million deaths globally were due to non-communicable diseases (NCDs) with LMICs accounting for 80% of the deaths (2). LMICs also continue to struggle in containing the relatively high disease burden from maternal and child ill-health and infectious diseases such as HIV/AIDS, tuberculosis, leading to a “double burden” of communicable and NCDs (3, 4). This not only poses further resource constraints to the already overstretched healthcare resources in LMICs but is also a threat to the attainment of equity in health and healthcare between and within countries (57).

The major NCDs—cardiovascular diseases (CVDs), cancers, chronic respiratory diseases and diabetes—present a unique challenge to the global health agenda of attaining universal health coverage (UHC)1 by 2030 (1). Furthermore, the detrimental health, economic, and developmental consequences of NCDs have seen their inclusion in the 2030 Sustainable Development Goals (SDGs) (8). SDG 3.4 explicitly aims to reduce by one-third premature mortality due to NCDs through prevention and treatment. Prioritising the reduction of shared NCDs risk factors such as physical inactivity, unhealthy diets, use of tobacco, and harmful use of alcohol is imperative to achieve the SDGs (9). Similarly, for hypertension which is a major risk factor for CVDs (1), evidence shows that increasing access to preventive interventions such as timely screening among those at risk and providing treatment to those diagnosed are cost-effective measures of attaining the NCD pre-mature mortality target (1012).

A well-functioning health system should ensure equity in the utilisation of health services, that is, based on need and not the ability to pay (13, 14). Yet, there is convincing evidence that the poor (who bear the greatest NCDs burden and are most in need of screening and treatment) relative to the rich, utilise NCDs healthcare services the least (1519). This phenomenon is termed the inverse care law (20). Demand and supply-side factors such as high levels of poverty, the substantial economic burden associated with the long-term care of NCDs, and insufficient health system capacity to handle NCDs (chiefly at the primary care level) are some of the reasons that contribute to socioeconomic inequalities in NCDs (1, 3, 15, 17, 2123).

Empirical evidence from previous studies that assessed inequity and socioeconomic inequality in hypertension converge to the same conclusion: that the poor, relative to the wealthy, utilise fewer hypertension services (15, 17, 18, 24, 25). Elwell-Sutton et al. (15), for instance, showed marked pro-rich inequality in the utilisation of treatment services for hypertension and dyslipidaemia in China. In addition, pro-rich horizontal inequity in the utilisation of hypertension, hyperglycaemia and dyslipidaemia treatment were reported in the same study (15). Of interest, income and other non-need factors (i.e., health insurance, education and longest-held occupation) mainly explained the observed inequality in NCDs treatment. These findings compare well with studies from other LMICs, which generally show that income, area of residence, level of education, occupational class, increasing age and lifestyle risk factors are significant contributors to the socioeconomic inequality in the prevalence or utilisation of NCD services (18, 25, 26).

In Kenya, NCDs account for 50% of hospitalisations and 55% of inpatient deaths, with estimates indicating that mortality due to NCDs is likely to increase by over 50% in the next decade (27). Besides, there are stark disparities in screening and treatment services utilisation for hypertension, mainly to the disadvantage of poorer socioeconomic groups. For example, 73% of the poorest quintile population have never been screened for hypertension compared to 38% in the richest quintile (27). Furthermore, a study in Kenya that estimated socioeconomic inequalities in hypertension prevalence found that the poor bore the highest burden, with body mass index (BMI), wealth status and education level mainly explaining the observed inequalities (24).

Although there is evidence suggesting inequalities in NCDs in Kenya, there is still a gap in knowledge, especially in assessing horizontal equity (i.e., equal treatment for equal need) in utilising screening and treatment for NCDs based on need. Also, to our knowledge, no study has assessed the factors contributing to socioeconomic inequality in using both interventions for hypertension in the Kenyan context. Therefore, using a nationally representative NCDs risk factors survey data set, this study aims to assess horizontal inequity in the screening and treatment of hypertension and decompose socioeconomic inequalities in the screening and treatment of hypertension in Kenya.

Methods

Data

This paper used the most recent and nationally representative cross-sectional STEPwise survey (STEPs) conducted by the Kenya National Bureau of Statistics (KNBS) between April and June 2015 in the country's 47 counties (27). The survey used the fifth National Sample Survey and Evaluation Programme (NASSEP V) master sample frame developed by the KNBS. The sample frame was developed using the Enumeration Areas (EAs) generated from the 2009 Kenya Population and Housing Census to form 5,360 clusters split into four equal sub-samples. A three-stage cluster sample design was used to collect the STEPs data. In the first stage, a total of 200 clusters (100 rural and 100 urban) were selected systematically from the NASSEP V sampling frame using the equal probability selection method to ensure the resulting sample retained the properties of probability proportional to size as was used in the creation of the frame. The second sampling stage involved a uniform selection of 30 households from the listed households in each cluster. An eligible participant was randomly selected from listed household members in the third sampling stage (27).

A total of 6,000 households were identified, but 4,754 consented (i.e. 79.2% response rate) and participated in the study. A total of 4,500 households were retained after data cleaning. A more detailed description of the STEPs data collection methodology is contained elsewhere (27). Sample weights were included in the statistical analyses to ensure that estimates were nationally representative. De-identified data set from the STEPs survey (which is available upon request from KNBS) was used in this study. Additionally, ethics clearance was obtained from the Human Research Ethics Committee of the University of Cape Town (Ref: 186/2020).

Measuring Socioeconomic Status

Socioeconomic status (SES) can be measured using several approaches classified as “direct measures,” that is, expenditure, income, consumption; and “proxy measures,” including education, occupation or social class, but mainly asset indices (28). It is important to note that there are debates on the right choice of SES measure regarding health inequality assessment. Some argue that the choice of welfare measure may not overly affect inequality findings (29, 30) while others maintain that the computed health inequality results could be sensitive, in some contexts, to the choice of welfare measure (28, 31). Following similar studies (17, 32) and based on data availability, principal component analysis (PCA) (33) was used in this paper to generate an index of SES.

Briefly, the multivariable statistical approach (PCA) reduces the number of variables in a data set into smaller dimensions (34). Put another way, beginning with an initial set of correlated variables, PCA generates uncorrelated components, in which case each component or index is a linear weighted combination of the original variables (33). The first principal component provides what is needed to construct a household welfare index–if it explains a substantial proportion of the variance, with larger weights assigned to assets that vary most across households (29, 34). Data on 15 selected variables (e.g. source of drinking water, type of sanitary facility, roof, floor and wall material, source of energy for cooking and lighting, and ownership of TV, radio, refrigerator, washing machine, bicycle, motorcycle, landline, and cell phone) were used to generate standardised weighted scores. These variables were used to create a dummy of each variable, signifying the presence of each item given that categorical variables are converted into a meaningless scale in PCA (35). The composite weighted index was used to rank the sample into five wealth quintiles (1—poorest, 5—richest).

Defining Hypertension

Having hypertension was defined in this paper based on any or all the three criteria: (1) previous hypertension diagnosis by a health worker, (2) use of prescribed anti-hypertensive medication or (3) having a systolic and/or diastolic blood pressure of ≥ 140/≥ 90 mmHg (36).

Measuring Need and Use of Hypertension Screening and Treatment

The need for hypertension screening was defined as individuals who smoke, are obese (≥ 30 kg/m2) and are 30 years and above (for both men and women), as stipulated in Kenya's cardiovascular treatment guidelines (36). The need for hypertension treatment was defined as those diagnosed with hypertension in the survey (i.e. a third systolic and/or diastolic blood pressure of ≥ 140/≥ 90 mmHg, respectively) (36).

The utilisation of screening services was assessed as having ever received a screening service for hypertension from a formal health provider (i.e. doctor or other health workers) before the survey. Similarly, utilisation of treatment was assessed as taking prescribed hypertension treatment two weeks before the survey. For a granular presentation of inequality findings, the share of need and use of screening and treatment interventions were compared across the SES groups and regional divides in Kenya. Table 1 further summarises the definitions of variables used in the analysis.

TABLE 1
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Table 1. Definitions of variables used in the analysis.

Analytical Approaches

Measuring Inequality in Care Utilisation

Inequality in screening and treatment can be assessed using various methodological approaches, as discussed by Wagstaff et al. (37). This paper used the concentration curves and concentration indices to assess inequality in the screening and treatment of hypertension. The rationale for using these measures is their consistency in ranking individuals according to their SES; sensitivity to changes in population distribution across SES, and ability to assess relative vs. absolute inequality (3739). The concentration curve (CC) plots the cumulative share of the use of screening or treatment services (y-axis) against the cumulative share of households, ranked from poorest to richest (x-axis). So, if everyone uses screening or treatment services irrespective of their SES rank, the CC will consistently lie on the equality (45-degree) line. If, by contrast, there is a pro-poor (pro-rich) distribution in the use of screening or treatment services, the CC will lie above (below) the line of equality, with the gap between the CC and equality line depicting the extent of inequality (40).

The concentration index (CIH) was computed as twice the covariance between screening or treatment for hypertension and an individual's socioeconomic rank divided by the mean of the health variable. Theoretically, the CIH lies between −1 (i.e. when the use of screening/treatment is concentrated on the poorest individual) and +1 (i.e. when the use of screening/treatment is concentrated on the richest individual). Overall, a positive (negative) CIH corresponds to a pro-rich (pro-poor) distribution. For a binary variable, the concentration index does not lie within the usual bounds but rather between (μH - 1) and (1- μH) and thus requires normalisation (41). Although there is a debate between Wagstaff (4143) and Erreygers (44, 45) regarding the appropriate normalisation approach, this paper used the Wagstaff's (41) normalisation primarily because the health variable of interest was binary (i.e. 1 = use of screening/treatment; 0 = otherwise).

Decomposing the Concentration Index of Screening and Treatment

While the CC and the CIH are relevant in examining the existence of socioeconomic inequalities in screening/treatment; they do not explain the factors contributing to observed inequality. Consequently, to understand the factors contributing to relative inequality, the CIH was further decomposed following the methodology suggested by Wagstaff et al. (46). Identifying these factors is critical for policy decisions around addressing the “underlying causes of inequality.” Thus, CIH can be decomposed as:

CIH=j=1JCj(βjZ¯j/μH) Deterministic + (GCε/μH)Unexplained    (1)

where Cj (Z¯j) is the concentration index (mean) of the jth contributing factor, GCε is the generalised concentration index of the error term (ε) and βj is obtained from the linearly additive equation related to the contributing factors (z) to the screening or treatment variable (h) shown in Equation 2.

hi=α+jβjZij+ εi    (2)

where α and βj are the coefficients to be estimated and εi is the error term. The deterministic portion of the concentration index in Equation 1 can be interpreted as the contribution of each contributing factor (z) to the concentration index (CIH), which consists of two parts. It is a product of the concentration index of each contributing factor (Cj) and the elasticity of hi with respect to zj(i.e. NGj= βjZ¯j/μH). The unexplained portion is computed as the difference between CIH and the deterministic portion. The residual cannot be systematically explained by variations in the contributing factors across socioeconomic groups (46). The generalised linear model (with binomial family and identity link) was applied in the decomposition analysis (47). Guided by variable availability in the dataset and well-established literature in the field (15, 2426, 48, 49), determinants of care utilisation were separated into “need” (i.e. body mass index (BMI), age and sex for screening; age and sex only for treatment) and “non-need” (i.e. education level, exposure to media, employment status, rural or urban residence, and quintiles of SES) factors for both screening and treatment. A negative (positive) contribution suggests a given determinant contributes to inequality in the pro-poor (pro-rich) direction.

Given the challenge in computing analytical standard errors (SEs) for the components in the decomposition (i.e. elasticities and each contributing factor's contribution to the concentration index) in Equation 1, the bootstrap method (50, 51) was used to obtain such SEs in the analysis. The sampling structure of the data was taken into account as applied by Ataguba et al. (52) to avoid inconsistent estimates of bootstrap SEs. A total of 1,000 replications were used to estimate the SEs for each estimate.

Measuring Horizontal Inequity in Care Utilisation

Horizontal equity analysis assesses inequity in care utilisation by standardising health service utilisation based on need (40). Inequity in care use estimated through the horizontal inequity (HI) index embodies the principle that healthcare should be utilised according to need (i.e. “equal treatment for equal need”). The HI was computed as the difference between the concentration index for actual (observed) care utilisation and need-expected utilisation. An indirect standardisation approach was used to predict the need-expected utilisation of screening and treatment (40, 53). HI lies within the range of −1 to +1, with a negative (positive) value indicating a pro-poor (pro-rich) inequity. Theoretically, a zero value for HI means there is no inequity. To estimate how much care each individual would receive if they were treated equally to everyone in the sample with equal needs, we fitted a regression model (40). All statistical analyses were conducted in Stata (version 15.1).

Results

Descriptive Analysis

Most respondents were female (60%). About 30% aged 20–39 years and 47% had attained primary education (Table 2). Only 19% of respondents were not employed, and more than half (54%) resided in a rural area. Hypertension prevalence was 30%, with a higher prevalence among wealthier individuals (Table 2). In addition, the prevalence of hypertension was higher among obese individuals (52%) compared to other BMI categories (underweight 19%, normal 26%, and overweight 39%) (data not shown). Although there was no significant difference, the prevalence of hypertension was slightly higher among non-smokers (30%) compared to non-smokers (29%) (data not shown).

TABLE 2
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Table 2. Descriptive statistics grouped by wealth quintile.

Inequality in Need and Use of Hypertension Screening and Treatment Services

Poorer individuals had a higher need for hypertension screening (concentration curves lie above the equality line), while hypertension screening favoured the rich (concentration curves lie below the equality line) (Figure 1). Although not significant, the need for hypertension screening was pro-poor (CI = −0.036; p > 0.05). On the other hand, hypertension screening (CI = 0.293; p < 0.01) was significantly pro-rich (Table 3).

FIGURE 1
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Figure 1. Concentration curves showing need and use of hypertension (A) screening and (B) treatment in Kenya.

TABLE 3
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Table 3. Concentration indices for need and use of screening services for hypertension in Kenya (STEPs 2015).

A further breakdown of who benefits from hypertension screening revealed that the wealthier quintiles benefited disproportionately more than they should given their share of need (Figure 2A). For example, while only 17% of those needing hypertension screening are in the wealthiest quintile, 27% of individuals using screening interventions are in the wealthiest quintile (Figure 2A). There were disparities in the need and use of hypertension screening in all the regions (Figure 2B). For instance, the disparity between the share of need and use for hypertension screening was highest in the Rift Valley region (27% vs. 31%) (Figure 2B).

FIGURE 2
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Figure 2. Distribution of share of need and use of hypertension screening services by (A) wealth quintile and (B) regions in Kenya (STEPs 2015).

Figure 1B shows a pro-rich distribution of the need for hypertension treatment, a finding confirmed by the concentration indices in Table 3. The use of hypertension treatment was pro-rich (CI = 0.030; p > 0.05) (Table 3). However, none of the pro-rich or the pro-poor inequality findings for hypertension treatment was statistically significant at conventional levels. Individuals in the poorest quintile were disadvantaged in using hypertension treatment compared to their population share of need. For instance, while 17% of respondents needing hypertension treatment are in the poorest quintile, only 8% of those using hypertension treatment are in the poorest quintile (Figure 3A). Overall, a disproportionate share exists in using hypertension treatment in the Kenyan regions, given the population share of need. Notably, the disparity in the need and use of hypertension (28% vs. 20%) treatment was highest in the Rift Valley region (Figure 3B).

FIGURE 3
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Figure 3. Distribution of share of need and use of hypertension treatment services by (A) wealth quintile and (B) regions in Kenya (STEPs 2015).

Inequity in Using Screening and Treatment Services for Hypertension in Kenya

The use of hypertension screening was significantly pro-rich after controlling for need (HI = 0.185; p<0.001). Also, the use of hypertension treatment services was significantly pro-rich at conventional levels (Table 4).

TABLE 4
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Table 4. Inequity in the utilisation of screening and treatment services for hypertension in Kenya (STEPS 2015).

Decomposition of Inequality in Care Use

Summary results of the decomposition analysis of inequality in screening and treatment are presented in Figures 4, 5, showing an aggregate contribution of need and non-need factors. In general, non-need factors contributed most to the pro-rich inequality in screening and treatment. Specifically, wealth status, exposure to media, education, and area of residence contributed most to inequality in screening among the non-need factors for hypertension. For the need factors, BMI explained inequality in the pro-rich direction for hypertension screening. However, sex explained inequality in the pro-poor direction for hypertension screening (Figure 4).

FIGURE 4
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Figure 4. Summary contributions to SES inequality in the utilisation of screening services for hypertension in Kenya (STEPs 2015).

FIGURE 5
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Figure 5. Summary contributions to SES inequality in the utilisation of treatment services for hypertension in Kenya (STEPs 2015).

Non-need factors like wealth and employment status were the largest contributors (in the pro-rich direction) to the inequality in hypertension treatment (Figure 5). Additionally, age and education status also contributed to inequality in hypertension treatment in the pro-poor direction (Figure 5).

As shown in Table 5, sex was the main statistically significant contributor to inequality in hypertension screening among the need factors. Only a few categories are significant for some need factors like age and BMI. Among non-need factors, exposure to media was a statistically significant contributor (in the pro-rich direction) to inequality in hypertension screening. For hypertension treatment, age explained the inequality in the pro-poor direction. Among the non-need factors, wealth status explained, to a greater extent, inequality in hypertension (in the pro-rich direction) treatment (Table 5). However, none of the need and non-need contributors to inequality hypertension treatment was statistically significant at conventional levels.

TABLE 5
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Table 5. Decomposition analysis of inequality in the utilisation of screening and treatment services for hypertension in Kenya (STEPs 2015).

Discussion

This study demonstrated the existence of socioeconomic inequality and horizontal inequity in the use of screening and treatment interventions for hypertension in Kenya. These findings can serve as a baseline for future progress assessments towards attaining SDG 3.4 targeted at NCDs and UHC goals in Kenya. In general, the results confirm that need does not match the use of screening and treatment services for hypertension across the SES groups and the Kenyan regions.

This paper's findings add to the evidence that the Kenyan health system is unequal and inequitable (5456). It suggests that policy interventions geared towards attaining equity in the Kenyan health system should pay special attention to NCDs like hypertension. Among other policy options, it has been established that timely screening among those at risk and treatment among those diagnosed are cost-effective strategies for combating the burden of hypertension (10, 11). However, our findings reveal considerable gaps in meeting the population need for both interventions in Kenya.

Poorer socioeconomic groups need more hypertension screening than their wealthier counterparts, but wealthier socioeconomic groups benefit more from screening services than their share of need. This finding could, in part, be explained by broader access barriers such as availability (i.e. biased availability of health facilities in urban locations), acceptability (i.e. providers and patients attitudes and expectations of each other) and affordability of screening services (57). For instance, transport costs have been shown to not only lead to catastrophic expenditures for hypertension treatment in public health facilities in Kenya but also contribute to about 40% of total out-of-pocket costs (58). Furthermore, the unaffordability of NCDs screening services in Kenya has been documented, with healthcare costs being disproportionately higher in the private relative to the public sector (59). Sex was the primary “need” factor contributing to socioeconomic inequality in hypertension screening, suggesting that females are more likely to seek screening services for hypertension. A similar finding has been reported in a study that assessed socioeconomic inequality for diabetes and hypertension screening in South Africa (25). Of interest, being obese was the other significant contributor (in the pro-rich direction) to socioeconomic inequality in hypertension screening (Table 5). Given that being obese is a risk factor for cardiovascular diseases (27), this finding suggests that those who are wealthy and obese are more likely to utilise hypertension screening services compared to other BMI categories. Also, given that “non-need” determinants such as exposure to media and education contributed to inequality in the screening for hypertension in the pro-rich direction, unawareness of the importance of timely or early screening may provide some insights into the possible reasons for the underutilisation of screening services among poorer socioeconomic groups.

Whereas the geographic spread of health facilities in Kenya has increased over time (60), other supply-side factors such as the physical inaccessibility of health facilities remain a barrier for using screening services as the area of residence contributed to pro-rich inequality. Also, the weak health system capacity to offer care for NCDs, particularly at the primary care level, could explain the inequality in hypertension screening (61, 62). A fragmented health service delivery structure biased towards offering curative rather than preventive healthcare services is among examples of health system weaknesses (6365). The inequality and inequity in the screening for hypertension compare well with the findings of a South African study that has shown marked pro-rich inequality and inequity in the screening for hypertension, diabetes and cholesterol, with non-need factors (i.e. wealth status, health insurance, and education) mainly contributing to the inequality (25).

This study also found that hypertension treatment needs do not match how different SES groups use the service. The wealthier quintiles relative to the poorer ones benefited more than their treatment needs, and this disparity existed in the Kenyan regions. Among other things, this finding can be explained by the overall unaffordability of NCDs services in Kenya (59) and the low levels of health insurance coverage (66), with lower socioeconomic groups being disproportionately affected. Similar patterns have been reported in previous studies in Kenya that have assessed inequality in health and healthcare use or access at the sub-national level (24, 5456). While inequality in the use of hypertension treatment was not statistically significant, the horizontal inequity finding suggests that hypertension treatment is not distributed according to need. Besides, compared to the inequality observed in hypertension screening, the “relative equality” in hypertension treatment could be partly explained by the difference in distribution of the burden of hypertension in the Kenyan population (i.e. 42% of rural dwellers have hypertension while 30% of urban dwellers have hypertension). Therefore, it can be argued that the pro-rich distribution in the use of hypertension treatment services could be as a result of the pro-urban bias in the distribution of healthcare facilities in Kenya and thus the rural dwellers are disadvantaged at utilising hypertension treatment services while they are most in need (60). Of note, the findings compare well with previous multi-country studies that found significant pro-rich inequality in the use of secondary cardiovascular medicines in LMICs (17) and hypertension treatment (32).

In the decomposition analysis of inequality in hypertension treatment, non-need factors primarily contributed to the observed inequality. For instance, area of residence, wealth, employment and education status contributed to inequality in hypertension treatment. Similar findings have been reported in China, where non-need factors such as income, area of residence, longest-held occupation, and level of education were significant contributors to the socioeconomic inequality in the utilisation of hypertension, hyperglycaemia and dyslipidaemia treatment (15). Unlike findings from other settings (18, 26), in this study, hypertension prevalence was higher among wealthier socioeconomic groups than their poorer counterparts. This disproportionate hypertension burden may lead to differences in healthcare demand between the rich and the poor in Kenya.

Several policy recommendations are imperative from the findings of this study. First, since service delivery falls within the docket of county governments in Kenya, there is an urgent need to enhance the capacity of primary care facilities to implement cost-effective strategies such as timely screening so that need can match service use for this critical intervention. Second, for demand in the utilisation of screening services to be increased, national and county governments, including other relevant actors, should implement strategic awareness-raising campaigns targeting at-risk populations as age and sex contributed to the SES inequality in the screening of hypertension. This can be through targeted health education messages in the mass media and other appropriate channels. Third, while recent efforts by the government of Kenya to attain UHC by 2022 are timely and commendable, more needs to be done to ensure the realisation of equity in the use of NCD services. Given the interplay of factors beyond the health sector that affect health, as was seen in the role of non-need factors in contributing to inequality in screening and treatment, there is a need for multi-sectoral approaches at various levels (i.e. local, national and regional) to address drivers of poverty and social inequity with a critical focus in marginalised areas. Some of the sectors that could collaborate with the health sector in addressing inequities/inequalities in NCDs include education and media. For instance, for increased health education on NCDs, the education sector can include NCDs in the curriculum. Also, various media channels can be used to raise awareness on the benefits of early NCDs screening as exposure to media was shown to contribute to SES inequality in hypertension screening.

Study Strengths and Limitations

This study had strengths and limitations. One key strength was the national representativeness of the data set used, which gave the national picture of socioeconomic inequality and inequity in the screening and treatment for hypertension in Kenya. Also, while previous studies have mainly assessed inequalities in the prevalence of NCDs (and in most cases using self-reported data), this study examines inequity and socioeconomic inequality in key interventions using objective measures of need for screening and treatment. This study also used a novel methodological approach: the decomposition analysis, to uncover factors contributing to socioeconomic inequality in screening and treatment for hypertension in Kenya.

This study also had limitations. The first limitation was data-driven. As is common in studies on care utilisation, we relied on self-reported data in defining the use of both screening and treatment. This could potentially bias our inequality findings, especially if there were cases of misreporting. Likewise, although previous studies (67, 68) have reported no association between under-reporting of care utilisation and demographic characteristics, except for age, we cannot rule out under-reporting of care utilisation in the low SES groups. Second, the STEPs data set was cross-sectional in design and thus limiting the establishment of temporal trends in inequality and inequity in the use of screening and treatment. Furthermore, it is essential to note that causality is not implied for the factors explaining observed inequality in screening and treatment.

Conclusion

Kenya faces a rising disease burden from non-communicable diseases, as expected in many low-and middle-income countries. This paper provides the first empirical evidence on socioeconomic inequality and inequity in screening and treatment interventions for NCDs based on need in Kenya. These findings provide a benchmark for future equity and equality assessments for NCDs in Kenya. In keeping with the global UHC agenda and other key NCDs targets, there is an urgent need for concerted efforts to ensure equity in providing NCDs healthcare services in Kenya. Indeed, given the ongoing policy reforms to attain UHC in Kenya, a window of opportunity exists to avert inequity in NCDs, with this paper highlighting some of the critical issues for consideration.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics Statement

The studies involving human participants were reviewed and approved by Human Research Ethics Committee of the University of Cape Town (Ref: 186/2020). The patients/participants provided their written informed consent to participate in this study.

Author Contributions

RO, JA, and EB conceived the study. RO conducted the data analysis and wrote the first draft of the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

The authors acknowledge funding support from the Wellcome Trust International Masters Fellowship (Grant Award Number: 214622) awarded to RO. EB is funded by a Wellcome Trust core grant (#092654).

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Acknowledgments

The authors are grateful to KNBS for providing the data set used in this study.

Footnotes

1. ^UHC aims to ensure utilisation of quality healthcare services by everyone based on need and without suffering financial hardship.

References

1. World Health Organization. Global Status Report on Noncommunicable Diseases 2014. World Health Organization (2014).

Google Scholar

2. Naghavi M, Abajobir AA, Abbafati C, Abbas KM, Abd-Allah F, Abera SF, et al. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. (2017) 390:1151–210. doi: 10.1016/S0140-6736(17)32152-9

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Aikins Ad-G, Agyemang C. Chronic Non-communicable Diseases in Low and Middle-income Countries. Wallingford: Cabi (2015).

PubMed Abstract | Google Scholar

4. Kengne AP. Mayosi BM. Readiness of the primary care system for non-communicable diseases in sub-Saharan Africa. Lancet Glob Health. (2014) 2:e247–e8. doi: 10.1016/S2214-109X(14)70212-8

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Aikins Ad-G, Kushitor M, Koram K, Gyamfi S, Ogedegbe G. Chronic non-communicable diseases and the challenge of universal health coverage: insights from community-based cardiovascular disease research in urban poor communities in Accra, Ghana. BMC Public Health. (2014) 14:S3. doi: 10.1186/1471-2458-14-S2-S3

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Bonfrer I, van de Poel E, Grimm M, Van Doorslaer E. Does the distribution of healthcare utilization match needs in Africa? Health Policy Plan. (2013) 29:921–37. doi: 10.1093/heapol/czt074

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Di Cesare M, Khang Y-H, Asaria P, Blakely T, Cowan MJ, Farzadfar F, et al. Inequalities in non-communicable diseases and effective responses. Lancet. (2013) 381:585–97. doi: 10.1016/S0140-6736(12)61851-0

PubMed Abstract | CrossRef Full Text | Google Scholar

8. United Nations. Transforming Our World - the 2030 Agenda for Sustainable Development. (2015). Available online at: https://sustainabledevelopment.un.org/topics/sustainabledevelopmentgoals (accessed November 14, 2019).

Google Scholar

9. World Health Organization. From Burden to “Best Buys”: Reducing the Economic Impact of Non-Communicable Diseases in Low-and Middle-Income Countries. Geneva: WHO (2011).

Google Scholar

10. Baker J, Mitchell R, Lawson K, Pell J. Ethnic differences in the cost-effectiveness of targeted and mass screening for high cardiovascular risk in the UK: cross-sectional study. Heart. (2013) 99:1766–71. doi: 10.1136/heartjnl-2013-304625

PubMed Abstract | CrossRef Full Text | Google Scholar

11. Howard K, White S, Salkeld G, McDonald S, Craig JC, Chadban S, et al. Cost-effectiveness of screening and optimal management for diabetes, hypertension, and chronic kidney disease: a modeled analysis. Value in health. (2010) 13:196–208. doi: 10.1111/j.1524-4733.2009.00668.x

PubMed Abstract | CrossRef Full Text | Google Scholar

12. Schmidt H. Barnhill A. Equity and noncommunicable disease reduction under the sustainable development goals. PLos Med. (2015) 12:e1001872. doi: 10.1371/journal.pmed.1001872

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Carrin G, Mathauer I, Xu K, Evans DB. Universal coverage of health services: tailoring its implementation. Bull World Health Organ. (2008) 86:857–63. doi: 10.2471/BLT.07.049387

PubMed Abstract | CrossRef Full Text | Google Scholar

14. World Health Organization. Health Systems Financing: The Path to Universal Coverage. Geneva: World Health Organization (2012).

Google Scholar

15. Elwell-Sutton TM, Jiang CQ, Zhang WS, Cheng KK, Lam TH, Leung GM, et al. Inequality and inequity in access to health care and treatment for chronic conditions in China: the Guangzhou Biobank Cohort Study. Health Policy Plan. (2012) 28:467–79. doi: 10.1093/heapol/czs077

PubMed Abstract | CrossRef Full Text | Google Scholar

16. Mayosi BM, Flisher AJ, Lalloo UG, Sitas F, Tollman SM, Bradshaw D. The burden of non-communicable diseases in South Africa. Lancet. (2009) 374:934–47. doi: 10.1016/S0140-6736(09)61087-4

PubMed Abstract | CrossRef Full Text | Google Scholar

17. Murphy A, Palafox B, O'Donnell O, Stuckler D, Perel P, AlHabib KF, et al. Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study. Lancet Global Health. (2018) 6:e292–301. doi: 10.1016/S2214-109X(18)30031-7

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Sozmen K, Belgin U. Socioeconomic inequalities in non-communicable diseases and self assessed health in Turkey. Iran J Public Health. (2014) 43:736.

PubMed Abstract | Google Scholar

19. Vellakkal S, Millett C, Basu S, Khan Z, Aitsi-Selmi A, Stuckler D, et al. Are estimates of socioeconomic inequalities in chronic disease artefactually narrowed by self-reported measures of prevalence in low-income and middle-income countries? Findings from the WHO-SAGE survey. J Epidemiol Commun Health. (2015) 69:218–25. doi: 10.1136/jech-2014-204621

PubMed Abstract | CrossRef Full Text | Google Scholar

20. Hart JT. The inverse care law. Lancet. (1971) 297:405–12. doi: 10.1016/S0140-6736(71)92410-X

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Kane J, Landes M, Carroll C, Nolen A. Sodhi S. A systematic review of primary care models for non-communicable disease interventions in sub-Saharan Africa. BMC Fam Pract. (2017) 18:46. doi: 10.1186/s12875-017-0613-5

PubMed Abstract | CrossRef Full Text | Google Scholar

22. McIntyre D, Obse AG, Barasa EW, Ataguba JE. Challenges in Financing Universal Health Coverage in Sub-Saharan Africa. (2018). doi: 10.1093/acrefore/9780190625979.013.28

CrossRef Full Text | Google Scholar

23. World Health Organization. Assessing National Capacity for the Prevention and Control of Noncommunicable Diseases: Report of the 2019 Global Survey. WHO (2020).

Google Scholar

24. Gatimu SM, John TW. Socioeconomic inequalities in hypertension in Kenya: a decomposition analysis of 2015 Kenya STEPwise survey on non-communicable diseases risk factors. Int J Equity Health. (2020) 19:1–11. doi: 10.1186/s12939-020-01321-1

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Zulu T. Socioeconomic Inequalities in Non-Communicable Diseases in South Africa. Cape Town: University of Cape Town (2019).

Google Scholar

26. Su M, Si Y, Zhou Z, Shen C, Dong W, Fan X, et al. Comparing the income-related inequity of tested prevalence and self-reported prevalence of hypertension in China. Int J Equity Health. (2018) 17:82. doi: 10.1186/s12939-018-0796-y

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Ministry of Health. Kenya STEPwise Survey for Non-Communicable Diseases Risk Factors 2015 Report. (2015). Available online at: http://aphrc.org/wp-content/uploads/2016/04/Steps-Report-NCD-2015.pdf (accessed August 8, 2019).

Google Scholar

28. Chuma J, Molyneux C. Estimating inequalities in ownership of insecticide treated nets: does the choice of socio-economic status measure matter? Health Policy Plan. (2009) 24:83–93. doi: 10.1093/heapol/czn050

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Filmer D, Pritchett LH. Estimating wealth effects without expenditure data—or tears: an application to educational enrollments in states of India. Demography. (2001) 38:115–32. doi: 10.1353/dem.2001.0003

PubMed Abstract | CrossRef Full Text | Google Scholar

30. Wagstaff A, Watanabe N. What difference does the choice of SES make in health inequality measurement? Health Econ. (2003) 12:885–90. doi: 10.1002/hec.805

PubMed Abstract | CrossRef Full Text | Google Scholar

31. Lindelow MJHe. Sometimes more equal than others: how health inequalities depend on the choice of welfare indicator. Health Econ. (2006) 15:263–79. doi: 10.1002/hec.1058

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Palafox B, McKee M, Balabanova D, AlHabib KF, Bahonar A, Ismail N, et al. Wealth and cardiovascular health: a cross-sectional study of wealth-related inequalities in the awareness, treatment and control of hypertension in high-, middle-and low-income countries. Int J Equity Health. (2016) 15:1–14. doi: 10.1186/s12939-016-0478-6

PubMed Abstract | CrossRef Full Text | Google Scholar

33. Vyas S, Kumaranayake L. Constructing socio-economic status indices: how to use principal components analysis. Health Policy Plan. (2006) 21:459–68. doi: 10.1093/heapol/czl029

PubMed Abstract | CrossRef Full Text | Google Scholar

34. Howe LD, Hargreaves JR, Huttly SR. Issues in the construction of wealth indices for the measurement of socio-economic position in low-income countries. Emerg Themes Epidemiol. (2008) 5:3. doi: 10.1186/1742-7622-5-3

PubMed Abstract | CrossRef Full Text | Google Scholar

35. McKenzie DJ. Measuring inequality with asset indicators. J Popul Econ. (2005) 18:229–60. doi: 10.1007/s00148-005-0224-7

CrossRef Full Text | Google Scholar

36. Ministry of Health. Kenya National Guidelines for Cardiovascular Diseases Management. Nairobi: Ministry of Health. 2018.

Google Scholar

37. Wagstaff A, Paci P, Van Doorslaer E. On the measurement of inequalities in health. Soc Sci Med. (1991) 33:545–57. doi: 10.1016/0277-9536(91)90212-U

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Ataguba JE, Akazili J, McIntyre D. Socioeconomic-related health inequality in South Africa: evidence from general household surveys. Int J Equity Health. (2011) 10:48. doi: 10.1186/1475-9276-10-48

PubMed Abstract | CrossRef Full Text | Google Scholar

39. Kakwani N, Wagstaff A, Van Doorslaer E. Socioeconomic inequalities in health: measurement, computation, and statistical inference. J Econom. (1997) 77:87–103. doi: 10.1016/S0304-4076(96)01807-6

PubMed Abstract | CrossRef Full Text | Google Scholar

40. O'Donnell O, Van Doorslaer E, Wagstaff A, Lindelow M. Analyzing Health Equity Using Household Survey Data: A Guide to Techniques and Their Implementation. Washington, DC: The World Bank (2008). doi: 10.1596/978-0-8213-6933-3

CrossRef Full Text | Google Scholar

41. Wagstaff A. The bounds of the concentration index when the variable of interest is binary, with an application to immunization inequality. Health Econ. (2005) 14:429–32. doi: 10.1002/hec.953

PubMed Abstract | CrossRef Full Text | Google Scholar

42. Wagstaff A. Correcting the concentration index: a comment. J Health Econ. (2009) 28:516–20. doi: 10.1016/j.jhealeco.2008.12.003

PubMed Abstract | CrossRef Full Text | Google Scholar

43. Wagstaff A. The concentration index of a binary outcome revisited. Health Econ. (2011) 20:1155–60. doi: 10.1002/hec.1752

PubMed Abstract | CrossRef Full Text | Google Scholar

44. Erreygers G. Correcting the concentration index. J Health Econ. (2009) 28:504–15. doi: 10.1016/j.jhealeco.2008.02.003

PubMed Abstract | CrossRef Full Text | Google Scholar

45. Erreygers G, Van Ourti T. Putting the cart before the horse: a reply to Wagstaff on inequality measurement in the presence of binary variables. Health Econ. (2011) 20:1161. doi: 10.1002/hec.1754

PubMed Abstract | CrossRef Full Text | Google Scholar

46. Wagstaff A, Doorslaer vE, Watanabe N. On decomposing the causes of health sector inequalities with an application to malnutrition inequalities in Vietnam: J Hum Resour. (2003) 112:207–23. doi: 10.1016/S0304-4076(02)00161-6

CrossRef Full Text | Google Scholar

47. Yiengprugsawan V, Lim LL, Carmichael GA, Dear KB, Sleigh AC. Decomposing socioeconomic inequality for binary health outcomes: an improved estimation that does not vary by choice of reference group. BMC Res Notes. (2010) 3:57. doi: 10.1186/1756-0500-3-57

PubMed Abstract | CrossRef Full Text | Google Scholar

48. Niessen LW, Mohan D, Akuoku JK, Mirelman AJ, Ahmed S, Koehlmoos TP, et al. Tackling socioeconomic inequalities and non-communicable diseases in low-income and middle-income countries under the sustainable development agenda. Lancet. (2018) 391:2036–46. doi: 10.1016/S0140-6736(18)30482-3

PubMed Abstract | CrossRef Full Text | Google Scholar

49. Williams J, Allen L, Wickramasinghe K, Mikkelsen B, Roberts N, Townsend N. A systematic review of associations between non-communicable diseases and socioeconomic status within low-and lower-middle-income countries. J Glob Health. (2018) 8:020409. doi: 10.7189/jogh.08.020409

PubMed Abstract | CrossRef Full Text | Google Scholar

50. Efron B. Better bootstrap confidence intervals. J Am Stat Assoc. (1987) 82:171–85. doi: 10.1080/01621459.1987.10478410

CrossRef Full Text | Google Scholar

51. Efron B, Tibshirani R. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy: rejoinder. Stat Sci. (1986) 1:77. doi: 10.1214/ss/1177013817

CrossRef Full Text | Google Scholar

52. Ataguba JE, Ojo KO, Ichoku HE. Explaining socio-economic inequalities in immunization coverage in Nigeria. Health Policy Plan. (2016) 31:1212–24. doi: 10.1093/heapol/czw053

PubMed Abstract | CrossRef Full Text | Google Scholar

53. Wagstaff A, Van Doorslaer E. Measuring and testing for inequity in the delivery of health care. J Hum Resour. (2000) 35:716–33. doi: 10.2307/146369

CrossRef Full Text | Google Scholar

54. Barasa E, Nguhiu P, McIntyre D. Measuring progress towards sustainable development goal 3.8 on universal health coverage in Kenya. BMJ Glob Health. (2018) 3:e000904. doi: 10.1136/bmjgh-2018-000904

PubMed Abstract | CrossRef Full Text | Google Scholar

55. Ilinca S, Di Giorgio L, Salari P, Chuma J. Socio-economic inequality and inequity in use of health care services in Kenya: evidence from the fourth Kenya household health expenditure and utilization survey. Int J Equity Health. (2019) 18:196. doi: 10.1186/s12939-019-1106-z

PubMed Abstract | CrossRef Full Text | Google Scholar

56. Nguhiu PK, Barasa EW, Chuma J. Determining the effective coverage of maternal and child health services in Kenya, using demographic and health survey data sets: tracking progress towards universal health coverage. Trop Med Int Health. (2017) 22:442–53. doi: 10.1111/tmi.12841

PubMed Abstract | CrossRef Full Text | Google Scholar

57. McIntyre D, Thiede M, Birch S. Access as a policy-relevant concept in low-and middle-income countries. Health Econ Policy Law. (2009) 4:179–93. doi: 10.1017/S1744133109004836

PubMed Abstract | CrossRef Full Text | Google Scholar

58. Oyando R, Njoroge M, Nguhiu P, Kirui F, Mbui J, Sigilai A, et al. Patient costs of hypertension care in public health care facilities in Kenya. Int J Health Plann Manage. (2019) 34:e1166–e78. doi: 10.1002/hpm.2752

PubMed Abstract | CrossRef Full Text | Google Scholar

59. Subramanian S, Gakunga R, Kibachio J, Gathecha G, Edwards P, Ogola E, et al. Cost and affordability of non-communicable disease screening, diagnosis and treatment in Kenya: patient payments in the private and public sectors. PLoS One. (2018) 13:e0190113. doi: 10.1371/journal.pone.0190113

PubMed Abstract | CrossRef Full Text | Google Scholar

60. Noor AM, Alegana VA, Gething PW, Snow RW. A spatial national health facility database for public health sector planning in Kenya in 2008. Int J Health Geogr. (2009) 8:13. doi: 10.1186/1476-072X-8-13

PubMed Abstract | CrossRef Full Text | Google Scholar

61. Ashigbie PG, Rockers PC, Laing RO, Cabral HJ, Onyango MA, Buleti JPL, et al. Availability and prices of medicines for non-communicable diseases at health facilities and retail drug outlets in Kenya: a cross-sectional survey in eight counties. BMJ Open. (2020) 10:e035132. doi: 10.1136/bmjopen-2019-035132

PubMed Abstract | CrossRef Full Text | Google Scholar

62. Government of Kenya. Kenya Service Availablity and Readiness Assessment Mapping (SARAM) Report. Nairobi: Ministry of Health (2014).

Google Scholar

63. Atun R, Jaffar S, Nishtar S, Knaul FM, Barreto ML, Nyirenda M, et al. Improving responsiveness of health systems to non-communicable diseases. Lancet. (2013) 381:690–7. doi: 10.1016/S0140-6736(13)60063-X

PubMed Abstract | CrossRef Full Text | Google Scholar

64. Ali MK, Rabadán-Diehl C, Flanigan J, Blanchard C, Narayan KV, Engelgau M. Systems and capacity to address noncommunicable diseases in low-and middle-income countries. Sci Transl Med. (2013) 5:181cm4–cm4. doi: 10.1126/scitranslmed.3005121

PubMed Abstract | CrossRef Full Text | Google Scholar

65. Beaglehole R, Epping-Jordan J, Patel V, Chopra M, Ebrahim S, Kidd M, et al. Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care. Lancet. (2008) 372:940–9. doi: 10.1016/S0140-6736(08)61404-X

PubMed Abstract | CrossRef Full Text | Google Scholar

66. Kazungu JS, Barasa EW. Examining levels, distribution and correlates of health insurance coverage in Kenya. Trop Med Int Health. (2017) 22:1175–85. doi: 10.1111/tmi.12912

PubMed Abstract | CrossRef Full Text | Google Scholar

67. Bhandari A, Wagner T. Self-reported utilization of health care services: improving measurement and accuracy. Med Care Res Rev. (2006) 63:217–35. doi: 10.1177/1077558705285298

PubMed Abstract | CrossRef Full Text | Google Scholar

68. Tsui EL, Leung GM, Woo PP, Choi S, Lo S-V. Under-reporting of inpatient services utilisation in household surveys–a population-based study in Hong Kong. BMC Health Serv Res. (2005) 5:31. doi: 10.1186/1472-6963-5-31

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: socioeconomic inequality, horizontal inequity, decomposition analysis, hypertension, Kenya

Citation: Oyando R, Barasa E and Ataguba JE (2022) Socioeconomic Inequity in the Screening and Treatment of Hypertension in Kenya: Evidence From a National Survey. Front. Health Serv. 2:786098. doi: 10.3389/frhs.2022.786098

Received: 29 September 2021; Accepted: 21 February 2022;
Published: 05 April 2022.

Edited by:

Chris Sampson, Office of Health Economics (OHE), United Kingdom

Reviewed by:

Eleanor Bell, Office of Health Economics (OHE), United Kingdom
Charlotte Dieteren, Erasmus University Rotterdam, Netherlands

Copyright © 2022 Oyando, Barasa and Ataguba. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Robinson Oyando, royando@kemri-wellcome.org

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