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Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00346

Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (ɛ-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing

 Irem Unalan1, Benedikt Slavik2,  Andrea Buettner2,  Wolfgang Goldmann3, Gerhard Frank1 and  Aldo R. Boccaccini1*
  • 1Institute of Biomaterials, University of Erlangen Nuremberg, Germany
  • 2Department of Chemistry and Pharmacy, Faculty of Science, University of Erlangen-Nürnberg, Germany
  • 3Department of Physics, Friedrich Alexander University Erlangen-Nuremberg, Germany

The aim of this study was to fabricate and characterize various concentrations of peppermint essential oil (PEP) loaded on poly(ɛ-caprolactone) (PCL) electrospun fiber mats for wound healing applications, where PEP was intended to impart antibacterial activity to the fibers. SEM images illustrated that the morphology of all electrospun fiber mats was smooth, uniform and bead-free. The average fiber diameter was reduced by the addition of PEP from 1.6±0.1 to 1.0±0.2 µm. Functional groups of the fibers were determined by Raman spectroscopy. Gas chromatography-mass spectroscopy (GC-MS) analysis demonstrated the actual PEP content in the samples. In vitro degradation was determined by measuring weight loss and their morphology change, showing that the electrospun fibers slightly degraded by the addition of PEP. The wettability of PCL and PEP loaded electrospun fiber mats was measured by determining contact angle and it was shown that wettability increased with the incorporation of PEP. The antimicrobial activity results revealed that PEP loaded PCL electrospun fiber mats exhibited inhibition against Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria. Our findings showed for the first time PEP loaded PCL electrospun fiber mats with antibiotic-free antibacterial activity as promising candidates for wound healing applications.

Keywords: Electrospinning, Antibacterial activity, Wound Healing, Polycaprolactone (PCL), peppermint essential oil

Received: 31 Jul 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 Unalan, Slavik, Buettner, Goldmann, Frank and Boccaccini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Aldo R. Boccaccini, Institute of Biomaterials, University of Erlangen Nuremberg, Erlangen, Germany,