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Front. Endocrinol. | doi: 10.3389/fendo.2018.00056

Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency

  • 1Diabetes Centre, Hull York Medical School, University of York, United Kingdom
  • 2Weill Cornell Medical College in Qatar, Qatar

Objective To evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD) .
Design Six months, double blind, randomised, cross over, placebo controlled trial of subcutaneous rGH in 17 patients with GHD.
Measurements Quadriceps muscle biopsies were obtained at baseline, 3 and 6 months to measure succinate dehydrogenase (SDH) to assess mitochondrial activity. Exercise capacity was measured with cardiopulmonary exercise testing. Lipids, glycaemic parameters and body fat levels were also measured.
Results IGF1 levels normalised with rGH in the active phase (p<0.005) with a reduction in total body fat (36.2±10.4% vs 37.6±10.7%, p<0.05). Patients showed an increase in SDH (P<0.01) from base line that differed between placebo and rGH therapy treatment groups (P<0.05): those treated by rGH followed by placebo showed a significant rise in SDH (p<0.001) followed by a fall, with a significant between group difference at the end of 6 months (p<0.05). No significant improvements or correlation with exercise capacity was found.
Conclusions Short term rGH for 3 months had a significant effect on mitochondrial function, favourably altered body mass and IGF1 levels, but exercise capacity was unchanged.

Keywords: recombinant growth hormone, Mitochondria, Succinate Dehydrogenase, Exercise Tolerance, growth hormone deficiency

Received: 23 Oct 2017; Accepted: 07 Feb 2018.

Edited by:

Rosario Pivonello, University of Naples Federico II, Italy

Reviewed by:

Ya-Xiong Tao, Auburn University, United States
Cesar L. Boguszewski, SEMPR UFPR, Brazil
Masaaki Yamamoto, Cedars-Sinai Medical Center, United States  

Copyright: © 2018 Gonzalez, Sathyapalan, Javed and Atkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Stephen Atkin, Weill Cornell Medical College in Qatar, Ar-Rayyan, Qatar, sla2002@qatar-med.cornell.edu