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Peripheral Regulators of Obesity

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Front. Endocrinol. | doi: 10.3389/fendo.2018.00406

Slim body weight is highly associated with enhanced lipoprotein functionality, higher HDL-C and large HDL particle size in young women

Suk-Jeong Kim1,  Dhananjay Yadav1, Jae-Ryong Kim2 and  Kyung-Hyun Cho1*
  • 1Department of Medical Biotechnology, Yeungnam University, South Korea
  • 2Department of Biochemistry and Molecular Biology, Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, South Korea

There has been no information about the correlations between body weight distribution and lipoprotein metabolism in terms of high-density lipoproteins-cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP). In this study, we analyzed the quantity and quality of HDL correlations in young women (21.5±1.2-years-old) with a slim (n=21, 46.2±3.8 kg) or plump (n=30, 54.6±4.4 kg) body weight. Body weight was inversely correlated with the percentage of HDL-C in total cholesterol (TC). The plump group showed 40% higher body fat (26±3 %) and 86% more visceral fat mass (VFM, 1.3±0.3 kg) than the slim group, which showed 18±2% body fat and 0.7±0.2 kg of VFM. Additionally, the plump group showed 20% higher TC, 58% higher triglyceride (TG), and 12% lower HDL-C levels in serum. The slim group showed 34% higher apoA-I but 15% lower CETP content in serum compared to the plump group. The slim group showed a 13% increase in particle size and 1.9-fold increase in particle number with enhanced cholesterol efflux activity. Although the plump group was within a normal body mass index (BMI) range, its lipid profile and lipoprotein properties were distinctly different from those of the slim group in terms of CETP mass and activity, HDL functionality, and HDL particle size.

Keywords: Body Weight, Blood Pressure, Lipoproteins, ApoA-I, HDL-Cholesterol

Received: 09 Mar 2018; Accepted: 29 Jun 2018.

Edited by:

Sudip Bajpeyi, The University of Texas at El Paso, United States

Reviewed by:

Andrew J. Murphy, Baker Heart and Diabetes Institute, Australia
C R. White, University of Alabama at Birmingham, United States
Brie Sorrenson, University of Auckland, New Zealand
Andras G. Lacko, University of North Texas Health Science Center, United States  

Copyright: © 2018 Kim, Yadav, Kim and Cho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Kyung-Hyun Cho, Yeungnam University, Department of Medical Biotechnology, Gyeongsan, South Korea, chok@yu.ac.kr