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Clinical Trial ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00796

Progestin versus gonadotropin-releasing hormone antagonist for the prevention of premature luteinizing hormone surges in poor responders undergoing in vitro fertilization treatment: a randomized controlled trial

 Qiuju Chen1*, Weiran Chai1, Yun Wang1, Renfei Cai1, Shaozhen Zhang1, Xuefeng Lu1, Xiaojing Zeng1,  Yanping Kuang1 and Lihua Sun1
  • 1Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, China

Progestin was recently used as an alternative of gonadotropin-releasing hormone (GnRH) analogue for preventing premature luteinizing hormone (LH) surge with the aid of vitrification techniques, however, limited data were available about the potential of progestin in poor responders undergoing undergoing in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) treatment. We performed a randomized parallel controlled trial to investigate the difference of progestin and GnRH antagonist in poor responders. A total of 340 poor responders who met with Bologna criteria were randomly allocated into the progestin-primed ovarian stimulation (PPOS) group and GnRH antagonist group. Fresh embryo transfer was preferred in the GnRH antagonist group and freeze-all was performed in the PPOS group. The primary outcome was the incidence of premature LH surge, secondary outcomes were the number of retrieved oocytes, the number of viable embryos and the pregnancy outcomes. The results showed that the incidence of premature LH surge in PPOS group was lower than that in antagonist group (0 versus 5.88%, P<0.05). In PPOS group, the average numbers of oocytes and viable embryos were comparable to those in GnRH antagonist group (3.7±2.6 versus 3.4±2.4; 1.6±1.7 versus 1.4±1.3, P>0.05), the live birth rate was similar between the two groups (21.8% versus 18.2%, RR 1.25 (95% confidence interval 0.73,2.13), P>0.05). The study demonstrated that PPOS had a more robust control for preventing premature LH rise than GnRH antagonist in poor responders, but PPOS in combination with freeze-all did not significantly increase the probability of pregnancy than GnRH antagonist protocol for poor responders.

Keywords: Progestin-primed ovarian stimulation, GnRH antagonist, premature LH surge, poor responders, controlled ovarian stimulation (COS)

Received: 26 Jun 2019; Accepted: 31 Oct 2019.

Copyright: © 2019 Chen, Chai, Wang, Cai, Zhang, Lu, Zeng, Kuang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Qiuju Chen, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China,