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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1358358

The causal relationship between 5 serum lipid parameters and diabetic nephropathy: A Mendelian Randomization study

Provisionally accepted
Hongzhou Liu Hongzhou Liu 1Xinxia Yao Xinxia Yao 2Linlin Wang Linlin Wang 1Jia Liu Jia Liu 1Xiaojing Li Xiaojing Li 1Xiaomin Fu Xiaomin Fu 3Jing Liu Jing Liu 3Song Dong Song Dong 1Yuhan Wang Yuhan Wang 4*
  • 1 Aerospace Clinical Medical College of Peking University, Beijing, Beijing Municipality, China
  • 2 Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 3 The first medical center, Chinese PLA General hospital, Beijing, China
  • 4 Beijing Friendship Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Serum lipids were found to be correlated with chronic kidney disease and cardiovascular disease. Here, we aimed to research the potential causal associations between five serum lipid parameters and the risk of diabetic nephropathy using several Mendelian Randomization methods.Methods: Genetic data was obtained from the UK Biobank datasets. Causal effects were estimated using multiple MR methods. Heterogeneity and pleiotropy tests were performed.Results: MR analysis revealed that HDL-C and TG exhibited causal associations with diabetic nephropathy (P<0.05). Similar trends were not observed for other lipid parameters.Our research has suggested links between HDL-C, TG and diabetic nephropathy.The findings could contribute to further elucidation of the disease etiology.

    Keywords: Mendelian randomization, Serum, Lipid, diabetic nephropathy, Instrumental variable

    Received: 19 Dec 2023; Accepted: 08 May 2024.

    Copyright: © 2024 Liu, Yao, Wang, Liu, Li, Fu, Liu, Dong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuhan Wang, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.