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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1380163
This article is part of the Research Topic Metabolic Syndrome in Patients with Diabetes: Identification of Biomarkers View all articles

Association between Heme oxygenase-1 and Hyperlipidemia in pre-diabetic patients: a cross-sectional study

Provisionally accepted
Shujin Fan Shujin Fan 1Yulin Yang Yulin Yang 1Xiaoyu Li Xiaoyu Li 2Jing Liu Jing Liu 1Yue Qiu Yue Qiu 1Li Yan Li Yan 1Meng Ren Meng Ren 1*
  • 1 Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
  • 2 First People's Hospital of Foshan, Foshan, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Although the importance and benefit of Heme oxygenase-1 (HO-1) in diabetes rodent models has been known, the contribution of HO-1 in the pre-diabetic patients with hyperlipidemia risk still remains unclear. This cross-sectional study aims to evaluate whether HO-1 is associated with hyperlipidemia in pre-diabetes.Serum level of HO-1 was detected using commercially available ELISA kit among 1425 participants aged 49.3 to 63.9 with pre-diabetes in a multicenter Risk Evaluation of cAncers in Chinese diabeTic Individuals: A lONgitudinal(REACTION) prospective observational study. Levels of total cholesterol (TC) and triglyceride (TG) were measured and used to defined hyperlipidemia. The association between HO-1 and hyperlipidemia was explored in different subgroups.The level of HO-1 in pre-diabetic patients with hyperlipidemia (181.72 ± 309.57 pg/ml) was obviously lower than that in pre-diabetic patients without hyperlipidemia (322.95 ± 456.37 pg/ml). High level of HO-1([210.18,1746.18] pg/mL) was negatively associated with hyperlipidemia (OR 0.60, 95% CI, 0.37-0.97, P = 0.0367) after we adjusted potential confounding factors. In subgroup analysis, high level of HO-1 was negatively associated with hyperlipidemia in overweight pre-diabetic patients (OR 0.50, 95% CI, 0.3-0.9, P = 0.034), especially in overweight female (OR 0.42, 95% CI, 0.21-0.84, P = 0.014).In conclusions, elevated HO-1 level was negatively associated with risk of hyperlipidemia in overweight pre-diabetic patients, especially in female ones. Our findings provide information on the exploratory study of the mechanism of HO-1 in hyperlipidemia, while also suggesting that its mechanism may be influenced by body weight and gender.

    Keywords: Hyperlipidemia, Heme Oxygenase-1, Pre-diabetes, Cross-sectional study, Association

    Received: 01 Feb 2024; Accepted: 29 Apr 2024.

    Copyright: © 2024 Fan, Yang, Li, Liu, Qiu, Yan and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meng Ren, Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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