Original Research ARTICLE
Interactions between Asaia and mosquito immune system: implications in malaria control
- 1School of Biosciences and Veterinary Medicine, University of Camerino, Italy
- 2MRC-University of Glasgow Centre For Virus Research (MRC), United Kingdom
- 3University of Camerino, Italy
In mosquitoes, the discovery of the numerous interactions between components of the microbiota and the host immune response opens up the attractive possibility of the development of novel control strategies against mosquito borne diseases. We have focused our attention to Asaia, a symbiont of several mosquito vectors who has been proposed as one of the most potential tool for paratransgenic applications; although being extensively characterized, its interactions with the mosquito immune system has never been investigated. Here we report a study aimed at describing the interactions between Asaia and the immune system of two vectors of malaria, Anopheles stephensi and An. gambiae. The introduction of Asaia isolates induced the activation of the basal level of mosquito immunity and lower the development of malaria parasite in An. stephensi. These findings confirm and expand the potential of Asaia in mosquito borne diseases control, not only through paratransgenesis, but also as a natural effector for mosquito immune priming.
Keywords: Asaia, Plasmodium, Malaria, Symbiotic control, Immune System
Received: 15 May 2019;
Accepted: 13 Aug 2019.
Edited by:Jayme A. Souza-Neto, São Paulo State University, Brazil
Reviewed by:Marcos H. Sorgine, Federal University of Rio de Janeiro, Brazil
Jose L. Ramirez, United States Department of Agriculture (USDA), United States
Copyright: © 2019 Cappelli, Damiani, Mancini, Valzano, Rossi, Serrao, Ricci and Favia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Guido Favia, University of Camerino, Camerino, Italy, email@example.com