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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00836

Interactions between Asaia and mosquito immune system: implications in malaria control

 Alessia Cappelli1, Claudia Damiani1, Maria V. Mancini2, Matteo Valzano1, Paolo Rossi1, Aurelio Serrao1,  Irene Ricci1 and  Guido Favia1, 3*
  • 1School of Biosciences and Veterinary Medicine, University of Camerino, Italy
  • 2MRC-University of Glasgow Centre For Virus Research (MRC), United Kingdom
  • 3University of Camerino, Italy

In mosquitoes, the discovery of the numerous interactions between components of the microbiota and the host immune response opens up the attractive possibility of the development of novel control strategies against mosquito borne diseases. We have focused our attention to Asaia, a symbiont of several mosquito vectors who has been proposed as one of the most potential tool for paratransgenic applications; although being extensively characterized, its interactions with the mosquito immune system has never been investigated. Here we report a study aimed at describing the interactions between Asaia and the immune system of two vectors of malaria, Anopheles stephensi and An. gambiae. The introduction of Asaia isolates induced the activation of the basal level of mosquito immunity and lower the development of malaria parasite in An. stephensi. These findings confirm and expand the potential of Asaia in mosquito borne diseases control, not only through paratransgenesis, but also as a natural effector for mosquito immune priming.

Keywords: Asaia, Plasmodium, Malaria, Symbiotic control, Immune System

Received: 15 May 2019; Accepted: 13 Aug 2019.

Edited by:

Jayme A. Souza-Neto, São Paulo State University, Brazil

Reviewed by:

Marcos H. Sorgine, Federal University of Rio de Janeiro, Brazil
Jose L. Ramirez, United States Department of Agriculture (USDA), United States  

Copyright: © 2019 Cappelli, Damiani, Mancini, Valzano, Rossi, Serrao, Ricci and Favia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Guido Favia, University of Camerino, Camerino, Italy, guido.favia@unicam.it