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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00839

Identification of a prognostic signature associated with DNA repair genes in ovarian cancer

 Hengzi Sun1,  Dongyan Cao1, xiangwen Ma1,  Jiaxin Yang1,  Peng Peng1, Mei Yu1, Huimei Zhou1, Ying Zhang1, Lei Li1,  Xiao Huo1* and  Keng Shen1
  • 1Peking Union Medical College Hospital (CAMS), China

Introduction: Ovarian cancer is a highly malignant cancer with a poor prognosis. At present, there is no accurate strategy for predicting the prognosis of ovarian cancer. A prognosis prediction signature associated with DNA repair genes in ovarian cancer was explored in this study.
Methods: Gene expression profiles of ovarian cancer were downloaded from the GEO, UCSC and TCGA databases. Cluster analysis, univariate analysis and stepwise regression were used to identify DNA repair genes as potential targets and a prognostic signature for ovarian cancer survival prediction. The top genes were evaluated by immunohistochemical staining of ovarian cancer tissues, and external data were used to assess the signature.
Results: A total of 28 DNA repair genes were identified as being significantly associated with overall survival (OS) among patients with ovarian cancer. The results showed that high expression of XPC and RECQL and low expression of DMC1 were associated with poor prognosis in ovarian cancer patients. The prognostic signature combining 14 DNA repair genes was able to separate ovarian cancer samples associated with different OS times and showed robust performance for predicting survival (Training set: p ˂ 0.0001, AUC = 0.759; Testing set: p ˂ 0.0001, AUC = 0.76).
Conclusion: Our study identified 28 DNA repair genes related to the prognosis of ovarian cancer. Using some of these potential biomarkers, we constructed a prognostic signature to effectively stratify ovarian cancer patients with different OS rates, which may also serve as a potential therapeutic target in ovarian cancer.

Keywords: DNA damage response, Genome integrity, Prognostic signature, Therapeutic target, ovarian cancer

Received: 15 Apr 2019; Accepted: 13 Aug 2019.

Edited by:

Ingrid A. Hedenfalk, Lund University, Sweden

Reviewed by:

Massimo Broggini, Istituto Di Ricerche Farmacologiche Mario Negri, Italy
Pilar Ramos, Caris Life Sciences, Inc, United States  

Copyright: © 2019 Sun, Cao, Ma, Yang, Peng, Yu, Zhou, Zhang, Li, Huo and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Xiao Huo, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China,