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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00945

Heterogeneity in Metabolic Responses to Dietary Fructose

  • 1Nutrition Research Institute, University of North Carolina at Chapel Hill, United States
  • 2Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, United States

Consumption of fructose has dramatically increased in past few decades in children and adults. Increasing evidence indicates that added sugars (particularly fructose) have adverse effects on metabolism and lead to numerous cardiometabolic diseases. Although both fructose and glucose are components of sucrose and high fructose corn syrup, the sugars have different metabolic fates in the human body and the effects of fructose on health are thought to be more adverse than glucose. Studies have also shown that the metabolic effects of fructose differ between individuals based on their genetic background, as individuals with specific SNPs and risk alleles seem to be more susceptible to the adverse metabolic effects of fructose. The current review discusses the metabolic effects of fructose on key complex diseases and discusses the heterogeneity of metabolic responses to dietary fructose in humans.

Keywords: genetic variants, Complex Diseases, Metabolic response, added sugars, individual variability

Received: 13 Nov 2018; Accepted: 05 Sep 2019.

Copyright: © 2019 Hou, Panda and Voruganti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Venkata Saroja Voruganti, University of North Carolina at Chapel Hill, Nutrition and Nutrition Research Institute, Chapel Hill, United States, saroja@unc.edu