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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.01033

The Roles of Non-coding RNAs in Neurodevelopmental Disorders

Shuang-Feng Zhang1*, Jun Gao2 and  Chang-Mei Liu1*
  • 1IOZ, Chinese Academy of Sciences, China
  • 2Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences & Peking Union Medical College, China

Non-coding RNAs, a group of ribonucleic acids that are ubiquitous in the body and do not encode proteins, emerge as important regulatory factors in almost all biological processes in the brain. Extensive studies have suggested the involvement of non-coding RNAs in brain development and neurodevelopmental disorders, and dysregulation of non-coding RNAs is associated with abnormal brain development and the etiology of neurodevelopmental disorders. Here we provide an overview of the roles and working mechanisms of non-coding RNAs, and discuss potential clinical applications of non-coding RNAs as diagnostic and prognostic markers and as therapeutic targets in neurodevelopmental disorders.

Keywords: Central Nervous System, non-coding RNAs, MicroRNAs, lncRNAs, Neurodevelopmental disorders

Received: 09 Dec 2018; Accepted: 25 Sep 2019.

Copyright: © 2019 Zhang, Gao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mr. Shuang-Feng Zhang, Chinese Academy of Sciences, IOZ, Beijing, China, 365922073@qq.com
Prof. Chang-Mei Liu, Chinese Academy of Sciences, IOZ, Beijing, China, liuchm@ioz.ac.cn