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ORIGINAL RESEARCH article

Front. Genet.
Sec. Applied Genetic Epidemiology
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1359108

Assessing Causality Between Obstructive Sleep Apnea with the Dyslipidemia and Osteoporosis: A Mendelian Randomization Study

Provisionally accepted
Ping-Yang Hong Ping-Yang Hong 1,2Dong Liu Dong Liu 3*Ang Liu Ang Liu 4Xin Su Xin Su 5Xiao-bin Zhang Xiao-bin Zhang 6*Yi-Ming Zeng Yi-Ming Zeng 1*
  • 1 Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China
  • 2 Zhongshan Hospital, Xiamen University, Xiamen, China
  • 3 Shantou University, Shantou, Guangdong Province, China
  • 4 Heze Municipal Hospital, Heze, Shandong, China
  • 5 Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
  • 6 School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    This study aims to assess the causal relationship between Obstructive Sleep Apnea (OSA), dyslipidemia, and osteoporosis using Mendelian Randomization (MR) techniques.Methods: Utilizing a two-sample MR approach, the study examines the causal relationship between dyslipidemia and osteoporosis. Multivariable MR analyses were used to test the independence of the causal association of dyslipidemia with OSA.Single nucleotide polymorphisms (SNPs) were selected as instrumental variables based on genome-wide significance, independence, and linkage disequilibrium criteria. The data were sourced from publicly available Genome-Wide Association Studies (GWAS) of OSA(n=375,657) from the FinnGen Consortium, the Global Lipids Genetics Consortium of dyslipidemia(n=188,577) and the UK Biobank for osteoporosis (n=456,348).The MR analysis identified a significant positive association between genetically predicted OSA and triglyceride levels (OR: 1.15, 95% CI: 1.04-1.26, p = 0.006) and a negative correlation with high-density lipoprotein cholesterol (HDL-C) (OR: 0.84, 95% CI: 0.77-0.93, p = 0.0003). Conversely, no causal relationship was found between dyslipidemia (total cholesterol, triglycerides, HDL-C, and low-density lipoprotein cholesterol) and OSA or the relationship between OSA and osteoporosis.The study provides evidence of a causal relationship between OSA and dyslipidemia, highlighting the need for targeted prevention and management strategies for OSA to address lipid abnormalities. The absence of a causal link with osteoporosis and in the reverse direction emphasizes the need for further research in this area.

    Keywords: obstructive sleep apnea, Dyslipidemia, Mendelian Randomization Analysis, Osteoporosis, Assessing Causality

    Received: 20 Jan 2024; Accepted: 24 May 2024.

    Copyright: © 2024 Hong, Liu, Liu, Su, Zhang and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dong Liu, Shantou University, Shantou, Guangdong Province, China
    Xiao-bin Zhang, School of Clinical Medicine, Fujian Medical University, Fuzhou, 350108, Fujian Province, China
    Yi-Ming Zeng, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China

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