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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.01202

Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with disease severity in systemic lupus erythematosus patients in an iNOS-dependent manner

  • 1Second Hospital of Anhui Medical University, China
  • 2Westmead Institute for Medical Research, Australia

Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythematosus (SLE) patients. Consequently, the level of circulating M-MDSCs was significantly increased in newly diagnosed SLE patients as compared to healthy controls. An elevated level of M-MDSCs was positively correlated with the disease severity in SLE patients and an immunosuppressive role was exerted in an iNOS-dependent manner. The decrease in the number of M-MDSCs after therapy rendered them as an indicator for the efficacy of treatment. These results demonstrated that M-MDSCs participated in the pathological progress in SLE patients. Thus, MDSCs are attractive biomarkers and therapeutic targets for SLE patients.

Keywords: myeloid-derived suppressor cells, SLE - systemic lupus erthematosus, iNOS - inducible nitric oxide synthase, Disease Severity, Immunosuppression

Received: 16 Jan 2019; Accepted: 13 May 2019.

Edited by:

Laurence Morel, University of Florida, United States

Reviewed by:

Natascha Köstlin-Gille, University Children's Hospital Tübingen, Germany
Roberto González-Amaro, Universidad Autónoma de San Luis Potosí, Mexico  

Copyright: © 2019 Zhai, Wang, Zhu, Wang, Tao, Xu, Wang, Xiong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Zhimin Zhai, Second Hospital of Anhui Medical University, Hefei, China, aydxyk@163.com