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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Immunol. | doi: 10.3389/fimmu.2019.02457

The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma

 Peng Liao1, 2, 3,  Wang Haofan1, 2, 3,  Yaling Tang1, 2, 3*, Ya-jie Tang4, 5, 6* and  Xin-hua Liang1, 2, 3*
  • 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, China
  • 2Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, China
  • 3Other, China
  • 4State Key Laboratory of Microbial Technology, Shandong University, China
  • 5Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, China
  • 6Hubei Collaborative Innovation Center for Industrial Fermentation, China

The development of Head and neck squamous cell carcinoma (HNSCC) is frequently accompanied by complex functional activities of immune cells and the suppression of immune cell function is also getting more and more attention. Normal activation of immune cells requires the coordination of costimulatory and coinhibitory signal molecules. The aberrant competition between these signal molecules directly affect the function of the immune cells and cytokine secretion, finally influence the tumor progression. This review will summarize the features of common costimulatory and coinhibitory molecules, analyze the underlying mechanism of these molecules regulating the malignant progression of HNSCC, and discuss the clinic application of blocking coinhibitory molecules. A deeper understanding of the tumor immune landscape will help insight new concepts to emerge in immune-checkpoint oncology and a new better tumor immunotherapy could be in prospect.

Keywords: HNSCC, costimulatory signaling molecules, coinhibitory signaling molecules, Immunity, Immunotherapy

Received: 22 Jul 2019; Accepted: 01 Oct 2019.

Copyright: © 2019 Liao, Haofan, Tang, Tang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Yaling Tang, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China, tangyaling@scu.edu.cn
Dr. Ya-jie Tang, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China, yajietang@qq.com
Dr. Xin-hua Liang, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China, lxh88866@scu.edu.cn