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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1383503
This article is part of the Research Topic Community Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume II View all 5 articles
The aging lung: microenvironment, mechanisms, and diseases
Provisionally accepted- 1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 2 The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu Province, China
- 3 Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China
- 4 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
- 5 Sichuan Academy of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 6 Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
- 7 School of Medicine, Tongji University, Shanghai, Shanghai Municipality, China
- 8 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 9 University of Electronic Science and Technology Hospital, Chengdu, Sichuan Province, China
With the development of global social economy and the deepening of the aging population, diseases related to aging have received increasing attention. The pathogenesis of many respiratory diseases remains unclear, and lung aging is an independent risk factor for respiratory diseases. The aging mechanism of the lung may be involved in the occurrence and development of respiratory diseases. Aging-induced immune, oxidative stress, inflammation, and telomere changes can directly induce and promote the occurrence and development of lung aging. Meanwhile, the occurrence of lung aging also further aggravates the immune stress and inflammatory response of respiratory diseases, the two mutually affect each other, and promote the development of respiratory diseases. Explaining the mechanism and treatment direction of these respiratory diseases from the perspective of lung aging will be a new idea and research field. This review summarizes the changes in pulmonary microenvironment, metabolic mechanisms, and the progression of respiratory diseases associated with aging.
Keywords: The aging lung: microenvironment, mechanisms, and diseases Aging, Immunity microenvironment, Mechanism, Lung Diseases, therapy
Received: 07 Feb 2024; Accepted: 16 Apr 2024.
Copyright: © 2024 Wang, Huang, Luo, Xu, Deng, Lin, Wang, Zhou, Wang, Chen, Tao, He, Yang, Yang, Chen, Jin, He, Zhongyu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Han Zhongyu, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, China
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