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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1383503
This article is part of the Research Topic Community Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume II View all 5 articles

The aging lung: microenvironment, mechanisms, and diseases

Provisionally accepted
Yanmei Wang Yanmei Wang 1Xuewen Huang Xuewen Huang 1Guofeng Luo Guofeng Luo 1Yunying Xu Yunying Xu 1Xiqian Deng Xiqian Deng 1Yumeng Lin Yumeng Lin 1Zhanzhan Wang Zhanzhan Wang 2Shuwei Zhou Shuwei Zhou 3Siyu Wang Siyu Wang 4Haoran Chen Haoran Chen 1Tao Tao Tao Tao 5Lei He Lei He 5Luchuan Yang Luchuan Yang 5Li Yang Li Yang 5Yutong Chen Yutong Chen 6Zi Jin Zi Jin 7Chengshi He Chengshi He 8Han Zhongyu Han Zhongyu 1*Xiaohong Zhang Xiaohong Zhang 9
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 2 The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu Province, China
  • 3 Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China
  • 4 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
  • 5 Sichuan Academy of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 6 Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
  • 7 School of Medicine, Tongji University, Shanghai, Shanghai Municipality, China
  • 8 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 9 University of Electronic Science and Technology Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    With the development of global social economy and the deepening of the aging population, diseases related to aging have received increasing attention. The pathogenesis of many respiratory diseases remains unclear, and lung aging is an independent risk factor for respiratory diseases. The aging mechanism of the lung may be involved in the occurrence and development of respiratory diseases. Aging-induced immune, oxidative stress, inflammation, and telomere changes can directly induce and promote the occurrence and development of lung aging. Meanwhile, the occurrence of lung aging also further aggravates the immune stress and inflammatory response of respiratory diseases, the two mutually affect each other, and promote the development of respiratory diseases. Explaining the mechanism and treatment direction of these respiratory diseases from the perspective of lung aging will be a new idea and research field. This review summarizes the changes in pulmonary microenvironment, metabolic mechanisms, and the progression of respiratory diseases associated with aging.

    Keywords: The aging lung: microenvironment, mechanisms, and diseases Aging, Immunity microenvironment, Mechanism, Lung Diseases, therapy

    Received: 07 Feb 2024; Accepted: 16 Apr 2024.

    Copyright: © 2024 Wang, Huang, Luo, Xu, Deng, Lin, Wang, Zhou, Wang, Chen, Tao, He, Yang, Yang, Chen, Jin, He, Zhongyu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Han Zhongyu, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.