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REVIEW article

Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1415573

Efferocytosis in Dendritic Cells: An Overlooked Immunoregulatory Process

Provisionally accepted
Yanyan Ma Yanyan Ma 1Tangxing Jiang Tangxing Jiang 2*Xun Zhu Xun Zhu 1*Yizhou Xu Yizhou Xu 1*Ke Wan Ke Wan 1*Tingxuan Zhang Tingxuan Zhang 1*Miaorong Xie Miaorong Xie 1*
  • 1 Beijing Friendship Hospital, Capital Medical University, Beijing, China
  • 2 Qilu Hospital, Shandong University, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.

    Keywords: Dendritic cell1, Apoptotic Cell2, Efferocytosis3, Immune regulation4, Antigen Cross-Presentation5, Treg Differentiation6

    Received: 10 Apr 2024; Accepted: 09 May 2024.

    Copyright: © 2024 Ma, Jiang, Zhu, Xu, Wan, Zhang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tangxing Jiang, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Xun Zhu, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Yizhou Xu, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Ke Wan, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Tingxuan Zhang, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    Miaorong Xie, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.