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Hemostasis in ECMO and VAD

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Front. Med. | doi: 10.3389/fmed.2019.00007

Acquired von Willebrand syndrome in patients with Ventricular Assist Device

  • 1Faculté de Médecine, Université de Lille 2, France
  • 2INSERM U1011 Récepteurs nucléaires, maladies cardiovasculaires et diabète, France
  • 3Division of Pediatric Hematology and Oncology, Medizinische Fakultät, Albert Ludwigs University of Freiburg, Germany

During the last decade the use of ventricular assist devices (VADs) for patients with severe heart failure has increased tremendously. However flow disturbances, mainly high shear induced by the device is associated with bleeding complications. Shear stress-induced changes in VWF conformation are associated with a loss of high molecular weight multimers of VWF and an increased risk of bleeding. This phenomenon and its cause will be elaborated and reviewed in the following.

Keywords: Von Willeband factor, ventricular assist device (VAD), Acquired von Willebrand syndrome, ECMO, bleeding

Received: 14 Oct 2018; Accepted: 11 Jan 2019.

Edited by:

Giancarlo Castaman, Università degli Studi di Firenze, Italy

Reviewed by:

Coen Maas, University Medical Center Utrecht, Netherlands
Shiu-Ki R. Hui, Department of Pediatrics, Baylor College of Medicine, United States  

Copyright: © 2019 Susen and Zieger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Sophie Susen, Faculté de Médecine, Université de Lille 2, Lille, France,