Comparison of combined intravenous and inhalation anesthesia and total intravenous anesthesia in laparoscopic surgery and the identification of predictive factors influencing the delayed recovery of neurocognitive function

1 Introduction

Laparoscopic surgery, known for its advantages of minimal trauma, reduced bleeding, and faster postoperative recovery compared to open surgery (1–3). The concept of anesthesia and perioperative Enhanced Recovery After Surgery has brought forth new and significantly higher demands on anesthesia during laparoscopic surgery (4, 5). It not only requires ensuring safe anesthesia but also focuses on achieving faster recovery. Therefore, it is essential to carefully select appropriate anesthesia methods and drugs that can minimize the psychological trauma and physiological stress experienced by patients during anesthesia and the perioperative period (6). This approach can also help reduce the incidence of postoperative side effects, shorten hospital stays, lower hospitalization costs, facilitate the patient’s prompt recovery, and improve the hospital turnover rate (7–9).

Currently, there are three commonly used methods of general anesthesia for laparoscopic surgery: total intravenous anesthesia (TIVA), simple inhalation anesthesia, and combined intravenous and inhalation anesthesia (CIVIA) (10, 11). Among these methods, two general anesthetic drugs, sevoflurane, and propofol, are widely used in clinical practice (12). Sevoflurane is a new type of halogen inhalation anesthetic that offers advantages such as fast induction, rapid recovery, simple operation, and strong controllability (13). It does not irritate the respiratory tract and effectively prevents intraoperative awareness and intuitive reaction to the depth of anesthesia. It also has less impact on circulation and provides benefits such as analgesia, muscle relaxation, and organ protection (14). On the other hand, propofol is a short-acting intravenous general anesthetic known for its quick onset, strong efficacy, and minimal side effects. However, compared to sevoflurane, propofol has poorer analgesic and muscle relaxant effects, and it may cause injection pain. It also has a stronger impact on breathing and circulation and is relatively more expensive (15).

The establishment of pneumoperitoneum and the administration of anesthetic drugs during laparoscopic surgery can have an impact on the hemodynamic stability of patients and the smooth recovery of postoperative cognitive function (16). The use of anesthetic drugs can lead to a higher stimulation response, thereby significantly affecting cognitive function (17, 18). This trial tries to compare the doses of analgesics and muscle relaxants administered per unit of time under two different anesthesia methods, as well as evaluate the postoperative recovery quality system. Our experiment aimed to evaluate the effects of two anesthesia techniques, CIVIA (Sevoflurane-Remifentanil) and TIVA (Propofol-Remifentanil), on the delayed neurocognitive recovery of older individuals who are subjected to laparoscopic abdominal surgery. Additionally, we aimed to identify any blood biomarkers associated with delayed neurocognitive recovery.

2 Materials and methods

2.1 Clinical research grouping

This study, which took place from March 2019 to March 2023, followed a prospective, single-blind, randomized controlled trial design. The Tongling Municipal Hospital Institution Review Committee approved this research on January 10, 2019, under the approval number 2019-099-02. The study was registered on Clinicaltrials.gov.cn in November 2018 (trial registration number: NCT03856760). During the preoperative evaluation, informed permission was obtained from each person before participants were randomly assigned. The trial complied with the reporting standards set out by CONSORT, the Consolidated Standards of Reporting Trials. The principles set out in the Helsinki Declaration were followed throughout all processes. For this research, 130 patients who were scheduled to have major laparoscopic abdominal surgery were chosen. Using a computer-generated random number system to evenly split the patients into the CIVIA and TIVA groups. Our researcher gathered 42 control patients who were not having surgery to guarantee the validity and accuracy of the repeated neuropsychological tests.

In this study, the research statistician utilized a computer to generate random numbers without any constraints, following a simple randomization process. The randomization codes were sealed in sequentially numbered envelopes and delivered to the research coordinator by a research nurse a day before the surgery. The coordinator then informed the anesthesiologists of the group assignments for the patients, who were assigned to study groups based on these randomization codes. Patients were divided into the CIVIA group and the TIVA group in a 1: 1 ratio. Preoperative interviews, eligibility assessments, obtaining written informed consent, participant inclusion, and postoperative follow-up were all carried out by investigators who were not involved in perioperative patient care prior to the study and were trained in neuropsychological assessment. Both patients and investigators were blinded to the group assignments and were unable to conduct group studies.

2.2 Inclusion criteria and exclusion criteria

Inclusion criteria: (1) Individuals scheduled for elective laparoscopic abdominal surgery; (2) Participants without significant audiovisual disabilities and possessing reading capability.

Exclusion criteria: (1) patients have a life expectancy of fewer than 3 months or have serious underlying diseases; (2) patients with an MMSE score of fewer than 23 points; (3) patients with dementia; (4) patients currently taking drugs that affect the nervous system; (5) patients with alcohol addiction or long-term drug dependence; (6) patients who have previously been included; (7) patients with difficulty in follow-up; (8) patients with uncontrolled hypertension (over 180/100 mmHg).

2.3 Anesthesia and perioperative nursing

Following the patient’s entrance into the operating room, an intravenous channel was established to administer the necessary substances. Routine ECG monitoring was conducted, along with the monitoring of various factors such as the depth of anesthesia (BIS), end-tidal partial pressure of CO₂ (PET CO₂), the concentration of inhaled anesthetics, and muscle relaxation (TOF value). Before anesthesia induction, preoperative drugs including penehyclidine 0.5 mg and dezocine 0.1 mg/kg were administered intravenously.

TIVA group: first, administer oxygen and denitrification for 5 min. Then, turn on the muscle relaxation monitor and initiate 4 series of stimulation (TOF) modes while monitoring the contraction of the adductor hallucis muscle. A dosage of 0.05 mg/kg of midazolam, 0.2 μg/kg/min of remifentanil, 1–2 mg/kg of propofol, and 0.15 mg/kg of rocuronium injection were administered. Following endotracheal intubation, the patient was attached to the anesthesia machine to facilitate mechanical ventilation.

CIVIA group: The procedure begins by providing oxygen and denitrification for 5 min. The muscle relaxation monitor is then turned on for calibration. Once the calibration is completed, the doses of midazolam and remifentanil are the same as those used in the TIVA group. Initially, the patient inhales 6 L/min of pure oxygen and 8% concentration of sevoflurane. After the patient’s eyelash reflex disappears, the oxygen flow rate is reduced to 1 L/min and the concentration of sevoflurane is lowered to 4%. After tracheal intubation, a dosage of 0.15 mg/kg of cisatracurium is administered through injection.

Both groups maintained intraoperative anesthesia using different methods. The TIVA group utilized continuous pumping to administer propofol (2 ~ 5 mg·kg⁻¹·h⁻¹) and remifentanil (0.1 ~ 0.3 μg·kg⁻¹·min-1). On the other hand, the CIVIA group employed inhalation of sevoflurane (1.0 MAC ~ 2.3 MAC) while administering the same dose of remifentanil as the TIVA group. To ensure the appropriate anesthesia level, the BIS value was maintained at 40–60 by adjusting the concentration of sevoflurane and the pumping speed of propofol. The pressure was maintained between 35 and 45 mmHg.

The administration of midazolam and cisatracurium ceased 30 min before the end of the operation. Intravenous prophylactic administration of azasetron (10 mg) was performed. The propofol infusion was stopped upon deflation of the abdomen or when sevoflurane inhalation was initiated. The remifentanil pump was discontinued after surgery. In the CIVIA group, anesthesia was discontinued and an artificial anesthesia gas adsorber was connected. The residual sevoflurane was eliminated using 6 L/min of fresh pure oxygen.

2.4 Observation index and data collection

The study recorded and observed the general conditions of two groups of patients, including age, gender, weight, height, and preoperative complications. The doses of analgesics (remifentanil) and muscle relaxants (cisatracurium) administered to each group of patients per unit of time were also observed and recorded. The following parameters were observed and recorded: the time from closing the sevoflurane tank to the extubation period, spontaneous breathing, spontaneous eye-opening, and removing the endotracheal tube. Additionally, the time when the two groups of patients entered the room (basic value Ta) and when the endotracheal tube was inserted (Tb), 5 min after endotracheal tube insertion (Tc), insufflation (Td), 5 min after insufflation (Te), end of skin suturing (Tf), endotracheal tube removal (Tg), and removal of BIS value 5 min after endotracheal tube (Th) were also observed and recorded. Furthermore, 20 min after extubation, the SAS and VAS were used to evaluate whether there was a difference in agitation and pain after extubation. Additionally, 5 mL of venous blood was drawn to detect biomarkers that could be associated with delayed recovery of neurocognitive function or postoperative cognitive dysfunction.

2.5 Enzyme-linked immunosorbent assay

Blood samples were taken from each participant, and left at room temperature for half an hour. Next, the samples were spun in a centrifuge to separate the liquid above, which was later kept for testing. The levels of IL-10, IL-1β, IL-6, TNF-a, VEGF, ICAM, TGF-β1, and APOE were determined using ELISA (19).

2.6 Neuropsychological assessment

Patients had cognitive testing the day before surgery and five to seven days thereafter. Similar to this, 6–9 days following the first exam, control individuals performed a second neuropsychological test. The delayed recovery of patients’ neurocognitive abilities was assessed using the following tests by the International Study of Postoperative Cognitive Dysfunction (ISPOCD): (1) Word Learning; (2) Word Recall; (3) Cognitive Flexibility; (4) Distraction; and (5) Work Memory, which was measured using an alphanumeric code. The neuropsychological assessment would be delayed for three days if the patient showed signs of disorientation during the exam. According to the criteria set forth by ISPOCD 1, the diagnosis of delayed neurocognitive recovery was made. In particular, patients were categorized as experiencing delayed neurocognitive recovery if their score on either of the two individual tests, represented by the Z-score or Z-combined value, was equal to or exceeded 1.96.

2.7 Statistical processing

The chi-square test or Fisher’s exact test were both used to analyze the categorical data, which were represented as frequencies (percentages). Depending on the distribution of the data, independent t-tests or Mann–Whitney U-tests were used to compare the continuous variables, which were provided as mean ± SD. To identify potential prognostic factors for delayed recovery of neurocognitive function, univariate logistic regression analysis was employed.

3 Results

3.1 Patient characteristics

130 individuals in all were originally screened for the trial. The screening procedure was carried out in accordance with the established inclusion and exclusion criteria for this research as well as the statistical data collected from specific trials. A total of 51 patients in the CIVIA group and 53 patients in the TIVA group successfully completed the trial in line with the stated protocol (Figure 1).

Figure 1

Figure 1. Flow chart of patient admission screening.

No noteworthy disparities in the fundamental data were observed between the CIVIA and TIVA groups (p > 0.05). Moreover, there were no statistically significant variations in preoperative complications among the two groups (p > 0.05) (Table 1).

Table 1

Table 1. Include the basic characteristics of the subjects ($\overline{x}\pm s$).

3.2 Comparative study on the dosage of anesthetics

According to the data presented in Table 2 and Figure 2, the CIVIA group required significantly lower doses of analgesics (remifentanil) and muscle relaxants (cisatracurium) per unit of time compared to the TIVA group (p < 0.001).

Table 2

Table 2. Comparison of anesthetic dosage per unit time between the two groups ($\overline{x}\pm s$).

Figure 2

Figure 2. Comparison of the dosage of two anesthetic drugs per unit of time between the two groups.

3.3 A comparative study on the awakening status of the two groups after anesthesia

According to the results presented in Table 3 and Figure 3, it was observed that in both groups of patients, the time interval from closing the sevoflurane tank to the extubation period for spontaneous breathing, the time taken for spontaneous eye opening during the extubation period.

Table 3

Table 3. Comparison of recovery after operation between the two groups ($\overline{x}\pm s$).

Figure 3

Figure 3. Comparison of recovery after operation between the two groups.

3.4 Comparison of anesthetic depth at different time points between the two groups

The depth of anesthesia was compared between the CIVIA group and TIVA group at various time points (p > 0.05): when the two groups of patients entered the room (Ta) when the endotracheal tube was inserted (Tb), 5 min after the insertion of the endotracheal tube (Tc), when the pneumoperitoneum was inflated (Td), and 5 min after inflation of the pneumoperitoneum (Te). Additionally, the depth of anesthesia was compared at the end of skin suturing (Tf), at the time of removal of the endotracheal tube (Tg), and 5 min after removal of the endotracheal tube (Th) (Table 4; Figure 4).

Table 4

Table 4. Comparison of anesthetic depth at different time points between the two groups ($\overline{x}\pm s$).

Figure 4

Figure 4. Comparison of anesthetic depth at different time points between the two groups.

3.5 A comparative study of pain and sedation and restlessness between the two groups after anesthesia

As shown in Table 5 and Figure 5, following extubation, the VAS scores between the two patient groups did not show a statistically significant difference (p > 0.05). Similarly, there was no statistically significant variance in the SAS scores between the two groups (p > 0.05).

Table 5

Table 5. Comparison of pain score and sedation and restlessness score after extubation between the two groups ($\overline{x}\pm s$).

Figure 5

Figure 5. Comparison of pain score and sedation score between the two groups after extubation.

3.6 Comparison of hospitalization days between two groups

There was no difference in total hospitalization days and postoperative hospital days between the CIVIA and TIVA groups (p > 0.05) (Figure 6; Table 6).

Figure 6

Figure 6. Comparison of hospitalization days between the two groups.

Table 6

Table 6. Comparison of hospitalization days between two groups ($\overline{x}\pm s$).

3.7 A comparative study of delayed neurocognitive recovery rate between the two groups

None of the patients experienced confusion during the predetermined test period, ensuring that the neuropsychological evaluation of each patient was not delayed. When analyzing the data according to the protocol, the control group exhibited a 4.8% delay rate in neurocognitive function recovery (2/42). In comparison, the CIVIA group and the TIVA group displayed significantly higher delay rates, with 13.72% (7/51) and 32.07% (17/53), respectively (p < 0.001). There is a variance in the rates of delayed neurocognitive recovery observed among the CIVIA and TIVA groups (p = 0.026) (Table 7).

Table 7

Table 7. The occurrence of delayed recuperation of neurocognitive abilities among individuals administered various forms of general anesthetics.

3.8 A comparative study on the content of serum cytokines between two groups

Table 8 and Figure 7 show that patients whose neurocognitive function recovery was slowed had higher levels of IL-6 than those whose recovery was not slowed (p = 0.018). It is also important to note that there was a significant interaction between time and group (p = 0.031), emphasizing the interaction between these two variables. Additional analysis revealed notable variations in IL-6 levels during T3 among individuals experiencing delayed neurocognitive recovery compared to those who did not encounter this issue (odds ratio, 1.06 [1.02 to 1.10]; p = 0.003). Although certain other blood factors demonstrated temporal alterations (VEGF, ICAM, TGF-β1, and ApoE), these factors did not differ at various time intervals between individuals with delayed neurocognitive recovery and those without such delay in cognitive recovery.

Table 8

Table 8. Comparing serum cytokine levels in patients with or without delayed neurocognitive recovery between these two study cohorts.

Figure 7

Figure 7. A comparison was conducted to assess the serum cytokine levels in patients with and without delayed neurocognitive recovery.

3.9 Prognostic factors of delayed recovery of neurocognitive function

Through the examination of univariate logistic regression, various risk factors that exerted an impact on the restoration of neurocognitive abilities were identified. These factors included age (p = 0.040), Mini-Mental State Examination score (p < 0.001), State-anxiety inventory score (p = 0.014), Trait-anxiety inventory score (p = 0.003), anesthesia time (p = 0.006), hospitalization time (p < 0.001), and IL-6 concentration at T3 (p = 0.003). The results demonstrate that increased age, longer duration of anesthesia, prolonged hospitalization, and elevated levels of IL-6 at T3 are correlated with a heightened occurrence of delayed neurocognitive restoration (Table 9).

Table 9

Table 9. A potential predictor analysis of neurocognitive recovery delay using univariate logistic regression.

4 Discussion

Laparoscopic surgery necessitates swift anesthesia induction, precise anesthesia depth control, and steady intraoperative hemodynamics. Additionally, it demands prompt postoperative recovery devoid of complications like respiratory depression, nausea, and vomiting (20, 21). This study explores the use of dual short-acting anesthetics in TIVA and CIVIA protocols to assess if the selection of anesthetic agents and methods influences the risk of delayed neurocognitive recovery or postoperative cognitive dysfunction.

After inhalation for anesthesia, sevoflurane is rapidly metabolized, facilitating the quick recovery of patients. Additionally, it offers convenient operation, ease of use, and control. Research has demonstrated that sevoflurane has several advantages over propofol, including minimal respiratory depression, simple anesthesia depth control, and safer postoperative recovery (22–24). This study found that the CIVIA group, which used sevoflurane for anesthesia induction and maintenance, had significantly shorter times for closing the sevoflurane tank to extubation, spontaneous eye-opening, and extubation of the endotracheal tube compared to the TIVA group. These findings indicate that patients who receive sevoflurane anesthesia can quickly regain consciousness after surgery, aligning with the results of previous analyses on the effects and economic benefits of different sevoflurane and propofol anesthesia schemes in laparoscopic surgery (25). Furthermore, it was observed in clinical application research that sevoflurane, when reaching a certain intensity, can induce muscle relaxation, with the degree of muscle relaxation increasing over time (26). The study also revealed that the CIVIA group required significantly lower doses of muscle relaxants per unit of time compared to the TIVA group. Both anesthesia methods demonstrated satisfactory analgesic effects, with sevoflurane potentially exhibiting a stronger analgesic effect than propofol. Notably, the CIVIA group had a significantly lower dosage of analgesics per unit of time than the TIVA group, suggesting that sevoflurane possesses analgesic properties that may surpass those of propofol.

Numerous clinical studies have investigated the impact of anesthetic agent choice and mode of anesthesia on the delay of neurocognitive recovery. Research findings indicate that the utilization of propofol as an anesthetic agent may result in a decreased occurrence of delayed neurocognitive recuperation in comparison to the use of volatile anesthetics (27). However, most previous studies have only utilized declines in Mini-Mental State Examination scores as a diagnostic measure for delayed neurocognitive recovery (28). The main objective of our investigation was to evaluate whether variations existed in the occurrence of postponed neurocognitive recuperation among individuals who received general anesthesia predominantly sustained with CIVIA and TIVA, particularly for laparoscopic procedures. Future studies should include multi-center, multi-sample studies to investigate potential differences in the incidence of delayed neurocognitive recovery between patients maintained under general anesthesia with CIVIA and TIVA.

As seen by their lower MMSE scores compared to individuals who did not have delayed neurocognitive recovery, it is interesting to note that these patients had worse cognitive performance (29). Additionally, these individuals spent longer in the hospital, which is consistent with other findings (30, 31). Age, Mini-mental State Examination score, State-anxiety inventory score, Trait-anxiety inventory score, duration of anesthesia, and length of hospital stay were found to be significant predictors of delayed neurocognitive recovery in the analysis of Univariate Logistic regression. One hour after the surgical incision, elevated blood levels of interleukin-6 have been shown to be a risk factor for a delayed neuropsychological recovery. Interleukin-6 levels rise after surgery, according to a number of studies (32, 33). According to these results, postoperatively elevated blood IL-6 levels were seen in both patients with and without delayed neurocognitive recovery. Patients who had a delayed neurocognitive recovery, however, had greater blood IL-6 levels than those who did not. This provides preliminary support for the idea that exacerbated inflammation may be a pathogenic factor in human neurocognitive recovery that is delayed (34). Within 24 h of surgery, no significant changes in blood levels of IL-1β, IL-10, or tumor necrosis factor were seen. These findings suggest that among surgical patients, some cytokines, such as interleukin-6, are induced by surgery.

5 Conclusion

Our study demonstrates that patients undergoing laparoscopic abdominal surgery under TIVA exhibit a greater likelihood of experiencing delayed neurocognitive recovery compared to those under CIVIA. Additionally, we have established that elevated serum levels of interleukin-6 serve as an independent risk factor for delayed neurocognitive recovery. These results offer valuable clinical insights into the connection between inflammation and delayed neurocognitive recovery.

Data availability statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.

Ethics statement

The studies involving humans were approved by the Institutional Review Board of Tongling Municipal Hospital on 10/1/2019 (approval number: 2019-099-02). All the experiments of this study were conducted in accordance to the relevant guidelines and regulations or in accordance to the Declaration of Helsinki. Informed consent was obtained from all subjects involved in the study. Written informed consent was obtained from all participants. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author contributions

TS: Conceptualization, Software, Writing – review & editing. L-JW: Investigation, Supervision, Writing – review & editing. LL: Writing – original draft, Writing – review & editing.

Funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Abbreviations

CIVIA, combined intravenous and inhalation anesthesia; TIVA, total intravenous anesthesia; MMSE, mini-mental state examination; ELISA, enzyme-linked immunosorbent assay; ISPOCD, international study of postoperative cognitive dysfunction; VAS, visual analog scale; IL-10, interleukin-10; IL-6, interleukin-6; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor; ICAM, intercellular cell adhesion molecule; TGF-β1, transforming growth factor-β1; ApoE, apolipoprotein E

References

1. Braschi, C, Liu, JK, Moazzez, A, and Petrie, BA. Is laparoscopic surgery safe for elderly patients with diverticulitis? A national database study. Langenbeck's Arch Surg. (2022) 407:3599–606. doi: 10.1007/s00423-022-02695-2

PubMed Abstract | Crossref Full Text | Google Scholar

2. Xiang, D, Xing, H, and Zhu, Y. A predictive nomogram model for postoperative delirium in elderly pati ents following laparoscopic surgery for gynecologic cancers. Support Care Cancer. (2022) 31:24. doi: 10.1007/s00520-022-07517-1

PubMed Abstract | Crossref Full Text | Google Scholar

3. Ma, Y, Zang, X, Qi, Y, Ju, B, and Ni, G. The curative effect of laparoscopic hysterectomy combined with pelvic floor suspension in patients with uterine prolapse and its effect on the levels of IGF-1 and TNF-alpha. J Basic Clin Pharm Toxicol. (2020) 127:84–5.

Google Scholar

4. Wang, C, Gan, L, Jiang, K, Gao, Z, and Ye, Y. Safety and efficacy of laparoscopic surgery versus open surgery in eld erly patients with Colon Cancer: a propensity score matching cohort study. Dig Surg. (2022) 39:255–62. doi: 10.1159/000529223

PubMed Abstract | Crossref Full Text | Google Scholar

5. Qiu, D, Wang, XM, Yang, JJ, Chen, S, Yue, CB, Hashimoto, K, et al. Effect of intraoperative Esketamine infusion on postoperative sleep Disturbance after Gynecological laparoscopy: a randomized clinical trial. JAMA Netw Open. (2022) 5:e2244514. doi: 10.1001/jamanetworkopen.2022.44514

PubMed Abstract | Crossref Full Text | Google Scholar

6. Lv, A-Q, Huang, LC, Lao, WL, Song, QL, Zhou, QF, Jiang, ZM, et al. Effects of different depth of anesthesia on perioperative inflammatory reaction and hospital outcomes in elderly patients undergoing laparoscopic radical gastrectomy. BMC Anesthesiol. (2022) 22:328. doi: 10.1186/s12871-022-01854-8

PubMed Abstract | Crossref Full Text | Google Scholar

7. Wang, E, Wang, L, Ye, C, Luo, N, Zhang, Y, Zhong, Y, et al. Effect of electroencephalography spectral edge frequency (SEF) and pat ient state index (PSI)-guided propofol-remifentanil Anesthesia on delirium after laparoscopic surgery: the eMODIPOD randomized controlled trial. J Neurosurg Anesthesiol. (2022) 34:183–92. doi: 10.1097/ANA.0000000000000823

PubMed Abstract | Crossref Full Text | Google Scholar

8. Della Corte, L, Mercorio, A, Morra, I, Riemma, G, de Franciscis, P, Palumbo, M, et al. Spinal Anesthesia versus general Anesthesia in Gynecological Laparosco pic surgery: a systematic review and Meta-analysis. Gynecol Obstet Investig. (2022) 87:1–11. doi: 10.1159/000521364

PubMed Abstract | Crossref Full Text | Google Scholar

9. Della Corte, L, Mercorio, A, Palumbo, M, Viciglione, F, Cafasso, V, Candice, A, et al. Minimally invasive anesthesia for laparoscopic hysterectomy: a case series. Arch Gynecol Obstet. (2022) 306:2001–7. doi: 10.1007/s00404-022-06727-6

PubMed Abstract | Crossref Full Text | Google Scholar

10. Niu, Z, Gao, X, Shi, Z, Liu, T, Wang, M, Guo, L, et al. Effect of total intravenous anesthesia or inhalation anesthesia on postoperative quality of recovery in patients undergoing total laparoscopic hysterectomy: a randomized controlled trial. J Clin Anesth. (2021) 73:110374. doi: 10.1016/j.jclinane.2021.110374

Crossref Full Text | Google Scholar

11. Nimmo, AF, Absalom, AR, Bagshaw, O, Biswas, A, Cook, TM, Costello, A, et al. Guidelines for the safe practice of total intravenous anaesthesia (TIV a): joint guidelines from the Association of Anaesthetists and the society for intravenous anaesthesia. Anaesthesia. (2019) 74:211–24. doi: 10.1111/anae.14428

PubMed Abstract | Crossref Full Text | Google Scholar

12. Wang, J, Cui, S, Kong, L, Ma, B, and Gu, J. Robustness of propofol and sevoflurane on the perioperative immune function of patients undergoing laparoscopic radical nephrectomy. J Oncol. (2022) 2022:1–6. doi: 10.1155/2022/1662007

Crossref Full Text | Google Scholar

13. Geng, W, Chen, C, Sun, X, and Huang, S. Effects of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery: arandomized controlled clinical studies. BMC Anesthesiol. 21:30. doi: 10.1186/s12871-021-01243-7

PubMed Abstract | Crossref Full Text | Google Scholar

14. Bansal, T, Singhal, S, and Kundu, K. Prospective randomized double-blind study to evaluate propofol and com bination of propofol and sevoflurane as maintenance agents in reducing postoperative nausea and vomiting in female patients undergoing laparoscopic surgery. Med Gas Res. (2022) 12:137–40. doi: 10.4103/2045-9912.337994

PubMed Abstract | Crossref Full Text | Google Scholar

15. Kim, JE, Koh, SY, and Jun, I-J. Comparison of the effects of propofol and sevoflurane Anesthesia on Op tic nerve sheath diameter in robot-assisted laparoscopic Gynecology Surgery: a randomized controlled trial. J Clin Med. (2022) 11:2161. doi: 10.3390/jcm11082161

PubMed Abstract | Crossref Full Text | Google Scholar

16. Han, M, Wu, X, Li, J, Han, S, and Rong, J. Effects of remote ischemic preconditioning on postoperative cognitive dysfunction in elderly patients with laparoscopic cholecystectomy. Int J Gen Med. (2023) 16:961–71. doi: 10.2147/IJGM.S401902

PubMed Abstract | Crossref Full Text | Google Scholar

17. Yang, B, Li, M, Liang, J, Tang, X, and Chen, Q. Effect of internal jugular vein catheterization on intracranial pressure and postoperative cognitive function in patients undergoing robot-assisted laparoscopic surgery. Front Med. (2023) 10:1199931. doi: 10.3389/fmed.2023.1199931

PubMed Abstract | Crossref Full Text | Google Scholar

18. Miller, D, Lewis, SR, Pritchard, MW, Schofield-Robinson, OJ, Shelton, CL, Alderson, P, et al. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac Surgery. Cochrane Database Syst Rev. (2018) 8:CD012317. doi: 10.1002/14651858.CD012317.pub2

Crossref Full Text | Google Scholar

19. Zhang, Y-X, Zhang, XT, Li, HJ, Zhou, TF, Zhou, AC, Zhong, ZL, et al. Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation. Int Immunopharmacol. (2021) 93:107165. doi: 10.1016/j.intimp.2020.107165

PubMed Abstract | Crossref Full Text | Google Scholar

20. Macías, A, and Finneran, JJCP. Regional Anesthesia techniques for pain Management for Laparoscopic Surgery: a review of the current literature. Curr Pain Headache Rep. (2022) 26:33–42. doi: 10.1007/s11916-022-01000-6 H. Reports

PubMed Abstract | Crossref Full Text | Google Scholar

21. Hao, C, Xu, H, du, J, Zhang, T, Zhang, X, Zhao, Z, et al. Impact of opioid-free Anesthesia on postoperative quality of recovery in patients after laparoscopic cholecystectomy-a randomized controlled trial. Drug Des Devel Ther. (2023) 17:3539–47. doi: 10.2147/DDDT.S439674

PubMed Abstract | Crossref Full Text | Google Scholar

22. Yang, L, Chen, Z, and Xiang, D. Effects of intravenous anesthesia with sevoflurane combined with propofol on intraoperative hemodynamics, postoperative stress disorder and cognitive function in elderly patients undergoing laparoscopic surgery. Pakistan J Med Sci. (2022) 38:1938–44. doi: 10.12669/pjms.38.7.5763

PubMed Abstract | Crossref Full Text | Google Scholar

23. Kim, S-J, Kwon, JY, Cho, AR, Kim, HK, and Kim, TK. The effects of sevoflurane and propofol anesthesia on cerebral oxygenation in gynecological laparoscopic surgery. Korean J Anesthesiol. (2011) 61:225–32. doi: 10.4097/kjae.2011.61.3.225

PubMed Abstract | Crossref Full Text | Google Scholar

24. Shinn, HK, Lee, MH, Moon, SY, Hwang, SI, Lee, CS, Lim, HK, et al. Post-operative nausea and vomiting after gynecologic laparoscopic surg ery: comparison between propofol and sevoflurane. Korean J Anesthesiol. (2011) 60:36–40. doi: 10.4097/kjae.2011.60.1.36

PubMed Abstract | Crossref Full Text | Google Scholar

25. Singh, Y, Singh, AP, Jain, G, Yadav, G, and Singh, DK. Comparative evaluation of cost effectiveness and recovery profile between propofol and sevoflurane in laparoscopic cholecystectomy. Anesth Essays Res. (2015) 9:155–60. doi: 10.4103/0259-1162.156290

PubMed Abstract | Crossref Full Text | Google Scholar

26. Honing, GHM, Martini, CH, Olofsen, E, Bevers, RFM, Huurman, VAL, Alwayn, IPJ, et al. Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery. Br J Anaesth. (2021) 126:377–85. doi: 10.1016/j.bja.2020.09.024

PubMed Abstract | Crossref Full Text | Google Scholar

27. Mahajan, VA, Ni Chonghaile, M, Bokhari, SA, Harte, BH, Flynn, NM, and Laffey, JG. Recovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane. Eur J Anaesthesiol. (2007) 24:505–10. doi: 10.1017/S0265021506001980

Crossref Full Text | Google Scholar

28. Vovk Racman, P, Kšela, J, Racman, M, Žerjav, U, and Šoštarič, M. Comparison of procedural sedation with propofol and dexmedetomidine During transcatheter aortic valve replacement using the transfemoral app roach. J Cardiothorac Vasc Anesth. (2023) 37:1894–900. doi: 10.1053/j.jvca.2023.05.009

Crossref Full Text | Google Scholar

29. Wang, G, Zhang, H, Sun, J, Zhang, Y, He, F, and Zou, J. Cyclosporin a impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-shh-BDNF pathway. Int Immunopharmacol. (2021) 96:107744. doi: 10.1016/j.intimp.2021.107744

PubMed Abstract | Crossref Full Text | Google Scholar

30. Qiao, H, Chen, J, Huang, Y, Pan, Y, Lu, W, Huang, Y, et al. Early neurocognitive function with propofol or desflurane Anesthesia after laser laryngeal surgery with low inspired oxygen. Laryngoscope. (2023) 133:640–6. doi: 10.1002/lary.30273

PubMed Abstract | Crossref Full Text | Google Scholar

31. Sun, H, Zhang, G, Ai, B, Zhang, H, Kong, X, Lee, WT, et al. A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer. BMC Cancer. (2019) 19:1248. doi: 10.1186/s12885-019-6426-2

PubMed Abstract | Crossref Full Text | Google Scholar

32. Shu, Z-B, Cao, HP, Li, YC, and Sun, LB. Influences of laparoscopic-assisted gastrectomy and open gastrectomy on serum interleukin-6 levels in patients with gastric cancer among Asian populations: a systematic review. BMC Gastroenterol. (2015) 15:52. doi: 10.1186/s12876-015-0276-4

PubMed Abstract | Crossref Full Text | Google Scholar

33. Maruszynski, M, and Pojda, Z. Interleukin 6 (IL-6) levels in the monitoring of surgical trauma. A comparison of serum IL-6 concentrations in patients treated by cholecystectomy via laparotomy or laparoscopy. Surg Endosc. (1995) 9:882–5. doi: 10.1007/BF00768883

Crossref Full Text | Google Scholar

34. Westman, G, Aurelius, E, Ahlm, C, Blennow, K, Eriksson, K, Lind, L, et al. Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex encephalitis. Clin Microbiol Infect. (2021) 27:1131–6. doi: 10.1016/j.cmi.2020.09.031

PubMed Abstract | Crossref Full Text | Google Scholar