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Front. Microbiol. | doi: 10.3389/fmicb.2018.00346

Searching for the bacterial effector: the example of the multi-skilled commensal bacterium Faecalibacterium prausnitzii

  • 1INRA Centre Jouy-en-Josas, France

Faecalibacterium prausnitzii represents approximately 5% of the total fecal microbiota in healthy adults being one of the most abundant bacterium in the human intestinal microbiota of healthy adults. Furthermore, this bacterium has been proposed to be a sensor and a major actor of the human intestinal health because of its importance in the gut ecosystem. In this context, F. prausnitzii population levels have been found to be reduced in patients suffering from several syndromes and diseases such as inflammatory bowel diseases. These diseases are characterized by a breakage of the intestinal homeostasis called dysbiosis and the use of F. prausnitzii as a next generation probiotic (also called live biotherapeutics) has been proposed as a natural tool to restore such dysbiosis within the gut. Nevertheless, despite the importance of this bacterium in human health, little is known about its main effectors underlying its beneficial effects. In this perspective note, we aim to present the actual state in the research about F. prausnitzii effectors and the future milestones in this field.

Keywords: probiotic, commensal, Faecalibacterium, bacterial effectors, next generation probiotics

Received: 24 Oct 2017; Accepted: 13 Feb 2018.

Edited by:

Vittorio Capozzi, University of Foggia, Italy

Reviewed by:

Valerio Iebba, Sapienza Università di Roma, Italy
Francesca Turroni, Università degli Studi di Parma, Italy  

Copyright: © 2018 Martín, Bermudez-Humaran and Langella. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Philippe Langella, INRA Centre Jouy-en-Josas, Jouy-en-Josas, France, philippe.langella@jouy.inra.fr