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Front. Microbiol. | doi: 10.3389/fmicb.2019.00294

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

  • 1Zhejiang University of Technology, China
  • 2Hangzhou Normal University, China

Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents.

Keywords: OSMAC strategy, microbe seondary metabolite, Structural diversity, medium composition, Co-cultivation, Epigenetic modifcation

Received: 11 Aug 2018; Accepted: 04 Feb 2019.

Edited by:

Dipesh Dhakal, Sun Moon University, South Korea

Reviewed by:

Juan C. Aon, GlaxoSmithKline (United States), United States
Anil Shrestha, Department of Chemistry and Nano Science, Ewha Womans University, South Korea  

Copyright: © 2019 Pan, Bai, Chen, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Huawei Zhang, Zhejiang University of Technology, Hangzhou, China, hwzhang@zjut.edu.cn
Prof. Hong Wang, Zhejiang University of Technology, Hangzhou, China, hongw@zjut.edu.cn