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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1269558

Effect Of Mastectomy On Gut Microbiota And Its Metabolites In Patients With Breast Cancer

Provisionally accepted
Pingming Fan Pingming Fan 1,2Linwei Ding Linwei Ding 1Guankui Du Guankui Du 1*Changyuan Wei Changyuan Wei 2
  • 1 Hainan Medical University, Haikou, Hainan Province, China
  • 2 Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    The relationship between gut microbiota and breast cancer has been extensively studied, however changes in gut microbiota after breast cancer surgery are still largely unknown.The patient underwent routine open surgery for breast cancer at the First Affiliated Hospital of Hainan Medical College from 2022.6.1 to 2022.12.1. Stool samples were collected from the patients preoperatively, 3 and 7 days postoperatively. Stool samples were subjected to 16s rRNA sequencing.Results: Surgery did not affect the α-diversity of gut microbiota. The β-diversity and composition of gut microorganisms was significantly affected by surgery in breast cancer patients. Both Lefse analysis and between-group differences analysis showed that surgery led to a decrease in the abundance of the Firmicutes and Lachnospiraceae, and an increase in the abundance of Proteobacteria and Enterobacteriaceae. Moreover, 127 differential metabolites were screened and classified into 5 categories based on their changing trends. KEGG enrichment analysis showed significant changes in phenylalanine metabolic pathway and exogenous substance metabolic pathway. Eight characterized metabolites were screened by ROC analysis.Our study found that breast cancer surgery significantly altered gut microbiota composition and metabolites, with decreases in beneficial bacteria and increases in potentially harmful bacteria. This underscores the importance of enhanced postoperative management to optimize gut microbiota.

    Keywords: breast cancer, Surgery, Gut Microbiota, Metabolites, 16S rRNA

    Received: 31 Jul 2023; Accepted: 30 Apr 2024.

    Copyright: © 2024 Fan, Ding, Du and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guankui Du, Hainan Medical University, Haikou, 571199, Hainan Province, China

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