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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microbiotechnology
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1407289
This article is part of the Research Topic Microbial Prospecting and Biomaterials View all 4 articles

Genomic insights into anthe antimicrobial compounds of the endophytic Streptomyces sp. VITGV156 for antimicrobial compounds Genomic insights into an endophytic Streptomyces sp. VITGV156 for antimicrobial compounds

Provisionally accepted
Veilumuthu Pattapulavar Veilumuthu Pattapulavar 1Nagarajan T Nagarajan T 2Sharayu Magar Sharayu Magar 2Sasikumar Sundaresan Sasikumar Sundaresan 3Lenus J. Moses Lenus J. Moses 1Thomas Theodore Thomas Theodore 1J Godwin Christopher J Godwin Christopher 1*
  • 1 VIT University, Vellore, Tamil Nadu, India
  • 2 SRM University, Amaravathi, Andhra Pradesh, India
  • 3 Madurai Kamaraj University, Madurai, Tamil Nadu, India

The final, formatted version of the article will be published soon.

    Endophytic Streptomyces spsspp. are recognized as a potential resource of valuable natural products, yetbut are less explored. This study focusesfocused on exploring endophytic Streptomyces species residing within tomato plants (Solanum lycopersicum) havingharboring genes for the production of a novel class of antibiotics. Our research work resulted ininvolved the isolation and characterization of Streptomyces sps VITGV156, a newly identified endophytic Streptomyces species, producing that produces antimicrobial products. VITGV156 harbors a genome of 8.18 mb and codes forencodes 6512 proteins, of which 4993 proteins of known function (76.67%), and 1519 proteins (23.32%) of unknown function. By employing genomic analysis, we elucidate the genome landscape of this microbial strain, and shed light on various BGCs responsible for producing polyketide antimicrobial compounds, with particular emphasis on the antibiotic kendomycin. We extended our study onby evaluating the antibacterial properties of kendomycin. Overall, this study provides valuable insights into the genome of endophytic Streptomyces species, particularly Streptomyces sps VITGV156, aswhich are prolific producers of antimicrobial agents. These findings hold promise for further research and exploitation in pharmaceutical compounds, offering opportunities for the development of novel antimicrobial drugs.

    Keywords: Streptomyces VITGV156, Endophytes, Tomato plant, Kendomycin, MRSA, antiSMASH, Biosynthetic gene cluster

    Received: 26 Mar 2024; Accepted: 29 Apr 2024.

    Copyright: © 2024 Pattapulavar, T, Magar, Sundaresan, Moses, Theodore and Christopher. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: J Godwin Christopher, VIT University, Vellore, 632 014, Tamil Nadu, India

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