Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
Hennariikka Koivisto1 Henri Leinonen1 Mari Puurula1 
Hani S. Hafez2 Glenda Alquicer Barrera3 
Malin H. Stridh4 
Helle S. Waagepetersen4 
Mika Tiainen5 
Pasi Soininen5 
Yuri Zilberter6 
Heikki Tanila1*- 1A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- 2Biology Department, Faculty of Science, Suez University, Suez, Egypt
- 3Institute of Physiology, Czech Academy of Sciences, v.v.i., Prague, Czechia
- 4Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 5NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland
- 6Institute de Neurosciences des Systèmes, Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale UMR_S 1106, Marseille, France
A corrigendum on
Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
by Koivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Alquicer Barrera, G., Stridh, M. H., et al. (2016). Front. Aging Neurosci. 8:41. doi: 10.3389/fnagi.2016.00041
In the Original Research article there was an error in the Section “Treatment” under the section “Methods” about the estimated daily intake of pyruvate:
“With the average food intake of 4 g this corresponds to 800 mg of pyruvate/day, which is at the upper range of effective pyruvate doses in earlier in vivo studies (Suh et al., 2005; Fukushima et al., 2009; Isopi et al., 2014).”
As correctly stated in the Abstract, the estimated dose was 800 mg of pyruvate/kg/day.
The corrected version of this section is shown below:
Treatment
Chronic Pyruvate Administration
The test group (PYR) received experimental chow supplemented with 0.6 % (w) of Na-pyruvate (Safe Diets, Augy, France). The control group (STD) received the same basic rodent chow (A04, Safe Diets). With the average food intake of 4 g this corresponds to 800 mg of pyruvate/kg/day, which is at the upper range of effective pyruvate doses in earlier in vivo studies (Suh et al., 2005; Fukushima et al., 2009; Isopi et al., 2014). Acute pyruvate administration. The mice received Na-pyruvate (Sigma, St. Louis, MO, USA) 500 mg/kg i.p. or the same molar concentration of NaCl (260 mg/kg i.p.). This single dose affords neuroprotection against cortical concussion injury and increases brain glucose and pyruvate levels as measured by in vivo microdialysis (Fukushima et al., 2009). All cage labels about the treatment groups were coded so that the researchers running behavioral tests or assays on post-mortem samples were blinded as to the treatment.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Keywords: Alzheimer's disease, aging, memory, explorative activity, glycogen
Citation: Koivisto H, Leinonen H, Puurula M, Hafez HS, Alquicer Barrera G, Stridh MH, Waagepetersen HS, Tiainen M, Soininen P, Zilberter Y and Tanila H (2017) Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice. Front. Aging Neurosci. 9:67. doi: 10.3389/fnagi.2017.00067
Received: 01 February 2017; Accepted: 06 March 2017;
Published: 20 March 2017.
Edited and reviewed by: Elizabeth J. Johnson, Tufts University, USA
Copyright © 2017 Koivisto, Leinonen, Puurula, Hafez, Alquicer Barrera, Stridh, Waagepetersen, Tiainen, Soininen, Zilberter and Tanila. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Heikki Tanila, Heikki.Tanila@uef.fi