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Front. Aging Neurosci. | doi: 10.3389/fnagi.2018.00415

Tooth loss is associated with increased risk of dementia and with a dose-response relationship

Jun Chen1, Chang-Ju Ren1,  Lan Wu2, Ling-Yun Xia1,  Jun Shao3,  Wei-Dong Leng1* and  Xian-Tao Zeng2*
  • 1Taihe Hospital, Hubei University of Medicine, China
  • 2Zhongnan Hospital, Wuhan University, China
  • 3Guangzhou Hospital of Integrated Traditional and Western Medicine, China

Objective: Both tooth loss and dementia are age-related frequently-occurring diseases, and increasing attentions have been paid to explore the pathogenesis related to oral-brain function disorders. The present study was performed to evaluate the association between tooth loss and dementia through a dose-response meta-analysis.
Methods: Relevant cohort studies were searched from online databases up to June 20, 2018, which examined the association between tooth loss and the risk of dementia. Literature selection according to inclusion and exclusion criteria, and data extraction from included studies were completed independently by two reviewers. Data syntheses in this meta-analysis were performed using Stata 12.0 software.
Results: A total of 8 cohort studies were included, containing a total of 14362 cases and 2072 dementia patients. The result of the meta-analysis indicated that patients with tooth loss faced 1.34 times greater risk of developing dementia (RR = 1.34,95% CI = 1.19-1.51). Meanwhile, the result from this dose-response meta-analysis in a linear model suggested that every missed tooth might increase the risk of dementia by 1.01 times (RR= 1.01, 95%CI = 1.00-1.02). Further subgroup analyses pointed out that tooth loss patients without dentures may have higher risk of dementia than those with dentures (with denture: RR = 0.98, 95% CI = 0.87-1.10; without denture: RR = 1.53, 95% CI = 1.19-1.97), meanwhile, study design, study area and education level of study participants might also have some effect on the results.
Conclusions: Tooth loss may be a risk factor for the development of dementia. Besides, there is a dose-response relationship along with the missed tooth increased.

Keywords: Tooth Loss, Dementia, Risk factor (source: MeSH, Dose-response analysis, Meta-analysis, periodontal disease (PD)

Received: 08 Aug 2018; Accepted: 03 Dec 2018.

Edited by:

Hanting Zhang, West Virginia University, United States

Reviewed by:

William B. Grant, Sunlight Nutrition and Health Research Center, United States
Jun Lyu, First Affiliated Hospital of Xi'an Jiaotong University, China  

Copyright: © 2018 Chen, Ren, Wu, Xia, Shao, Leng and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Wei-Dong Leng, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China, lengtaihe@163.com
Prof. Xian-Tao Zeng, Zhongnan Hospital, Wuhan University, Wuhan, 430071, Hubei Province, China, zengxiantao1128@163.com