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Front. Aging Neurosci. | doi: 10.3389/fnagi.2019.00033

The Relationship between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population with Normal Glucose Tolerance

Liuping Xiao1, Bo Ge1, Xu Chen2, Bo Chen3, Linyuan Qin2, Xueping Hu1, Haidong Pan1, Yujie Chen1, Li Tian4, Yun Gao4 and  Tianpeng Zheng1*
  • 1The Second Affiliated Hospital of Guilin Medical University, China
  • 2Guilin Medical University, China
  • 3Southwest Medical University, China
  • 4West China Hospital, Sichuan University, China

Objective: Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF ratio (DBR) in elderly population with normal glucose tolerance.
Methods: We cross-sectionally measured C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity, BDNF and calculated DBR in a total of 1,066 elderly participants in China. MCI was determined by Montreal Cognitive Assessment and finally confirmed by neurologists.
Results: An inverse correlation was found between DPP4 activity and BDNF(r=-0.456, P<0.001) and this inverse correlation was partly mediated by nitrotyrosine and 8-iso-PGF2a. Across rising quartiles of DBR, nitrotyrosine, 8-iso-PGF2a, C-reactive protein and interleukin-6 progressively increased, whereas Montreal Cognitive Assessment score progressively decreased. Subjects in the lowest quartile of BDNF and highest quartiles of DBR and DPP4 activity had higher MCI risk compared with subjects in the highest quartile of BDNF and lowest quartiles of DBR and DPP4 activity, respectively (all P<0.05). The odds ratios for MCI became more pronounced with decreased BDNF and increased DPP4.
Conclusion: In conclusion, a negative correlation was found between DPP4 activity and BDNF and this negative correlation was partly mediated by oxidative stress, not inflammation. DBR was positively associated with MCI and thus may be used as a novel risk biomarker for MCI in elderly population with normal glucose tolerance.

Keywords: Mild Cognitive Impairment, DPP4 activity to BDNF ratio, Oxidative Stress, Inflammation, Normal glucose tolerance

Received: 11 Nov 2018; Accepted: 05 Feb 2019.

Edited by:

J. Arturo García-Horsman, University of Helsinki, Finland

Reviewed by:

Zhigang Liu, Northwest A&F University, China
Anne-Marie Lambeir, University of Antwerp, Belgium  

Copyright: © 2019 Xiao, Ge, Chen, Chen, Qin, Hu, Pan, Chen, Tian, Gao and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Tianpeng Zheng, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Region, China,