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Peripheral Nerve Regeneration

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Front. Cell. Neurosci. | doi: 10.3389/fncel.2018.00427

Nerve repair using decellularized nerve grafts in rat models. A review of the literature.

 Arianna B. Lovati1*, Daniele D'Arrigo1, Simonetta Odella2,  Pierluigi Tos2,  Stefano Geuna3, 4 and  Stefania Raimondo3, 4
  • 1Istituto Ortopedico Galeazzi (IRCCS), Italy
  • 2Istituto Ortopedico Gaetano Pini, Italy
  • 3Ospedale San Luigi Gonzaga, Italy
  • 4Università degli Studi di Torino, Italy

Peripheral nerve regeneration after severe traumatic nerve injury is a relevant clinical problem. Several different strategies have been investigated to solve the problem of bridging the nerve gap. Among these, the use of decellularized nerve grafts has been proposed as an alternative to auto/isografts, which represent the current gold standard in the treatment of severe nerve injury. This study reports the results of a systematic review of the literature published between January 2007 and October 2017. The aim was to quantitatively analyze the effectiveness of decellularized nerve grafts in rat experimental models. The review included 33 studies in which eight different decellularization protocols were described. The decellularized nerve grafts were reported to be immunologically safe and able to support both functional and morphological regeneration after nerve injury. Chemical protocols were found to be superior to physical protocols. However, further research is needed to optimize preparation protocols, including recellularization, improve their effectiveness, and substitute the current gold standard, especially in the repair of long nerve defects.

Keywords: Nerve injury, Nerve Regeneration, allograft, decellularized nerve graft, rat model

Received: 02 Aug 2018; Accepted: 30 Oct 2018.

Edited by:

James Phillips, University College London, United Kingdom

Reviewed by:

Valerio Magnaghi, Università degli Studi di Milano, Italy
Tatsuro Mutoh, Fujita Health University, Japan  

Copyright: © 2018 Lovati, D'Arrigo, Odella, Tos, Geuna and Raimondo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: DVM, PhD. Arianna B. Lovati, Istituto Ortopedico Galeazzi (IRCCS), Milano, Italy,