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Front. Cell. Neurosci. | doi: 10.3389/fncel.2019.00328

TMP21 in Alzheimer’s disease: molecular mechanisms and a potential target

 kaixin Qiu1,  Xiaojie Zhang2,  Shuai Wang3,  Chunyan Li1, Xin Wang3, Xuezhi Li3 and  Yili Wu3*
  • 1Shandong University, China
  • 2Central South University, China
  • 3Jining Medical University, China

Alzheimer ’s disease (AD) is the most common form of dementia in the elderly, which is characterized by progressive cognitive impairment. Neuritic plaques, neurofibrillary tangles and neuronal loss are the major neuropathological hallmarks in AD brains. TMP21 is a key molecule for protein trafficking in cells. Growing evidence indicated indicates that TMP21 is dysregulated in AD, which plays a pivotal role in neuritic plaque formation. Therefore, we aim to review the dysregulation of TMP21 in AD, the role of TMP21 in neuritic plaque formation and underlying mechanisms. Moreover, the potential role of TMP21 in neurofibrillary tangle formation, synaptic impairment and neuronal loss is discussed. It will provide an outlook into the potential of regulating TMP21 as a therapeutic approach for AD treatment.

Keywords: Alzheimer’s disease, TMP21, Amyloid β-protein (Aβ), Tau phosphorylation, neuronal loss

Received: 23 Apr 2019; Accepted: 03 Jul 2019.

Edited by:

Rocío M. De Pablos, University of Seville, Spain

Reviewed by:

Sebastian Jimenez, Network Biomedical Research Center on Neurodegenerative Diseases (CIBERNED), Spain
María V. S. Micó, University of Seville, Spain  

Copyright: © 2019 Qiu, Zhang, Wang, Li, Wang, Li and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yili Wu, Jining Medical University, Jining, Shandong, China, yili_wu2004@yahoo.ca