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Front. Cell. Neurosci., 21 October 2019
Sec. Cellular Neurophysiology
Volume 13 - 2019 |

Corrigendum: Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells

  • 1Inserm, Institut du Fer à Moulin, Sorbonne Université, Paris, France
  • 2Inserm UMR-S 1270, Paris, France
  • 3Institut du Fer à Moulin, Paris, France
  • 4Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • 5Hector Institute for Translational Brain Research (gGmbH), Mannheim, Germany
  • 6German Cancer Research Center, Heidelberg, Germany

A Corrigendum on
Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells

by Penisson, M., Ladewig, J., Belvindrah, R., and Francis, F. (2019). Front. Cell. Neurosci. 13:381. doi: 10.3389/fncel.2019.00381

In the original article, the citation “(Kalebic et al., 2018)” was not cited in the article. The citation has now been re-inserted in the section Molecular Mechanisms Associated With the Generation and Amplification of bRGs, Including bRG-Like Cells in the Rodent, subsection Human and Primate Evolutionary Inventions, paragraph six ARHGAP11B. The new text is as follows:

“In transcriptome analyses from fetal human and mouse neocortices to identify human-specific genes underlying bRG expansion, ARHGAP11B was revealed to be expressed both in human aRGs and bRGs, but not in neurons (Florio et al., 2015). The gene derives from partial duplication of ARHGAP11A, coding for a Rho GTPase, after divergence from the chimpanzee. However, ARHGAP11B does not have Rho GTPase activity. After electroporation at E13.5 of a construct expressing ARHGAP11B, mouse brains showed an increased proportion of Tbr2+ cells at E15.5, and daughter cell analyses after microinjection in aRGs showed that ARHGAP11B promoted cell detachment and symmetrical division to produce two Tbr2+ cells. Also, some electroporated brains showed cortical folding. ARHGAP11B-dependent BP enrichment requires a specific splice donor site in the ARHGAP11B gene which is absent in the ancestral gene (Florio et al., 2016). It allows the protein to have a particular C-ter domain thought to be essential for ARHGAP11B to promote BP and bRG production. ARHGAP11B was later expressed by in utero electroporation in the ferret embryo at E33, where bRGs are naturally abundant (Kalebic et al., 2018). The number of BPs was increased at P0, including cycling and mitotic cells in the SVZ (particularly in the oSVZ). The proportion of Sox2+ cells was increased but the proportion of Tbr2+ cells was decreased in the SVZ. Primate like Sox2+/Tbr2- bRGs were thus increased. Overall, by using BrdU and EdU injections, the study showed that ARHGAP11B expression in the ferret extended the neurogenic period as compared to control animals. Consequently, ARHGAP11B increased the proportion of upper layer neurons with an increased proportion of Satb2+ neurons (Kalebic et al., 2018). Overall, this data shows that ARHGAP11B expression promotes BP generation differentially between mouse and ferret, with increased Tbr2+ cells in the mouse, and increased bRGs in the ferret, with both species showing cortical expansion. This human-specific gene could therefore also be a good candidate to help explain bRG amplification during human cortical development.”

The reference list has also been updated accordingly.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.


Florio, M., Albert, M., Taverna, E., Namba, T., Brandl, H., Lewitus, E., et al. (2015). Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. Science 347, 1465–1470. doi: 10.1126/science.aaa1975

PubMed Abstract | CrossRef Full Text | Google Scholar

Florio, M., Namba, T., Pääbo, S., Hiller, M., and Huttner, W. B. (2016). A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification. Sci. Adv. 2:e1601941. doi: 10.1126/sciadv.1601941

PubMed Abstract | CrossRef Full Text | Google Scholar

Kalebic, N., Gilardi, C., Albert, M., Namba, T., Long, K. R., Kostic, M., et al. (2018). Human-specificARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex. Elife 7:e41241. doi: 10.7554/eLife.41241

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: cortical development, neural progenitor cells, basal radial glia, cell division, spindle orientation, adhesion, signaling pathways

Citation: Penisson M, Ladewig J, Belvindrah R and Francis F (2019) Corrigendum: Genes and Mechanisms Involved in the Generation and Amplification of Basal Radial Glial Cells. Front. Cell. Neurosci. 13:462. doi: 10.3389/fncel.2019.00462

Received: 12 September 2019; Accepted: 30 September 2019;
Published: 21 October 2019.

Edited and reviewed by: Carlos Cardoso, INSERM U901 Institut de Neurobiologie de la Méditerranée, France

Copyright © 2019 Penisson, Ladewig, Belvindrah and Francis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Richard Belvindrah,; Fiona Francis,