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Front. Cell. Neurosci. | doi: 10.3389/fncel.2019.00513

Intra- and extracellular pillars of a unifying framework for homeostatic plasticity: A cross talk between metabotropic receptors and extracellular matrix

  • 1Department of Life Sciences, University of Trieste, Italy
  • 2Department of Experimental Medicine, School of Medical and Pharmaceutical Sciences, University of Genoa, Italy
  • 3Magdeburg, German Center for Neurodegenerative Diseases (DZNE), Germany

In the face of chronic changes in incoming sensory inputs, neuronal networks are capable of maintaining stable conditions of electrical activity over prolonged periods of time by adjusting synaptic strength, to amplify or dampen incoming inputs (homeostatic synaptic plasticity; HSP), or by altering the intrinsic excitability of individual neurons (homeostatic intrinsic plasticity, HIP). Emerging evidence suggests a synergistic interplay between extracellular matrix (ECM) and metabotropic receptors in both forms of homeostatic plasticity. Activation of dopaminergic, serotonergic or glutamate metabotropic receptors stimulates intracellular signaling through CaMKII, PKA, PKC and IP3Rs, and induces changes in expression of ECM molecules and proteolysis of both ECM molecules (lecticans) and ECM receptors (NPR, CD44). The resulting remodeling of perisynaptic and synaptic ECM provides permissive conditions for HSP and plays an instructive role by recruiting additional signaling cascades, such as those through mGluRs and integrins. The superimposition of all these signaling events determines intracellular and diffusional trafficking of ionotropic glutamate receptors, resulting in HSP and modulation of conditions for inducing Hebbian synaptic plasticity (i.e. metaplasticity). It also controls cell-surface delivery and activity of voltage- and Ca2+-gated ion channels, resulting in HIP. These mechanisms may modify epileptogenesis and become a target for therapeutic interventions.

Keywords: (5-8): mGluRs, Extracellular Matrix, HCN channels, SK channels, AMPARs, ADAMTS

Received: 07 Sep 2019; Accepted: 29 Oct 2019.

Copyright: © 2019 Cingolani, Vitale and Dityatev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Alexander Dityatev, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Bonn, Germany, alexander.dityatev@dzne.de