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Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.00108

The quest for an Alzheimer therapy

  • 1Istituto Universitario di Studi Superiori di Pavia (IUSS), Italy
  • 2Centro San Giovanni di Dio Fatebenefratelli (IRCCS), Italy

This mini-review considers three different approaches to the therapy and prevention of Alzheimer’s disease (AD): replacement therapy, disease modification, and multi-level interventions. Each of these research frameworks has direct implications at the clinical level, leading to an emphasis on different timepoints of the AD continuum. While all perspectives continue to play an important role in current efforts to reach the ambitious target of of an effective therapy or prevention of AD by 2025, it is clear than novel paradigms are needed, including new models of clinical trial design. This goal can only be accomplished by a concerted effort of academia, governmental agencies and industry.

Keywords: Alzheimer disease1, dementia prevention2, amyloid3, therapy4, diagnostic criteria5

Received: 09 Jan 2018; Accepted: 14 Feb 2018.

Edited by:

Fabio Blandini, Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IRCCS), Italy

Reviewed by:

Elena Marcello, Università degli Studi di Milano, Italy
Alfredo Costa, University of Pavia, Italy  

Copyright: © 2018 Cappa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Stefano F. Cappa, Istituto Universitario di Studi Superiori di Pavia (IUSS), Pavia, Italy, stefano.cappa@iusspavia.it