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Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00787

Diffusion tensor tractography studies of central post-stroke pain due to the spinothalamic tract injury: a mini-review

  • 1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, South Korea

Elucidation of the pathophysiological mechanism of central post-stroke pain (CPSP) is essential to the development of effective therapeutic modalities for CPSP. However, the pathophysiological mechanism of CPSP has not yet been clearly elucidated. The recent development of diffusion tensor tractography (DTT) derived from diffusion tensor imaging (DTI) has allowed visualization and estimation the spinothalamic tract (STT), which has been considered the most plausible neural tract responsible for pathogenesis of CPSP. In this mini-review, six DTT studies in which CPSP due to STT injury in stroke patients was demonstrated are reviewed. The information provided in the reviewed studies suggests that DTT is useful to elucidation of the pathophysiological mechanism associated with CPSP. We believe that the reviewed studies will facilitate neurorehabilitation of stroke patients with CPSP. However, DTT studies of CPSP are still in the beginning stage because the total number (six studies) of the reviewed studies is very short and half were case reports. Therefore, further studies involving large numbers of subjects are warranted.

Keywords: Central post-stroke pain, Stroke, Spinothalamic tract, Diffusion Tensor Imaging, Diffusion tensor tractography

Received: 10 May 2019; Accepted: 08 Jul 2019.

Edited by:

Nishant K. Mishra, MD, PhD, FESO, Icahn School of Medicine at Mount Sinai, United States

Reviewed by:

Richard Leigh, National Institutes of Health (NIH), United States
Hanna Braaß, University Medical Center Hamburg-Eppendorf, Germany  

Copyright: © 2019 Jang, Seo and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Sung Jun Lee, Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, South Korea,