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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00914

Multimodal quantitative MRI reveals no evidence for tissue pathology in idiopathic cervical dystonia

 René-Maxime Gracien1, 2,  Franca Petrov1, 2,  Pavel Hok3*, Alexandra van Weynen1, 2, Michelle Maiworm1, 2,  Alexander Seiler1, 2,  Ralf Deichmann2 and  Simon Baudrexel1, 2
  • 1Department of Neurology, University Hospital Frankfurt, Germany
  • 2Brain Imaging Center, Goethe University Frankfurt, Germany
  • 3Department of Neurology, Palacký University and University Hospital Olomouc, Czechia

Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results.

Objective: Using multimodal qMRI, the presented study aimed to investigate alterations in different cerebral microstructural compartments associated with idiopathic cervical dystonia in vivo.

Methods: Mapping of T1, T2, T2* and proton density (PD) was performed in 17 patients with idiopathic cervical dystonia and 29 matched healthy control subjects. Statistical comparisons of the parametric maps between groups were conducted for various regions of interest (ROI), including major basal ganglia nuclei, the thalamus, white matter and the cerebellum and voxel-wise for the whole brain.
Results: Neither whole brain voxel-wise statistics nor ROI-based analyses revealed significant group differences for any qMRI parameter under investigation.

Conclusions: The negative findings of this qMRI study argue against the presence of overt microstructural tissue change in patients with idiopathic cervical dystonia. The results seem to support a common view that idiopathic cervical dystonia might primarily resemble a functional network disease.

Keywords: Idiopathic dystonia, quantitative MRI, relaxometry, proton density, Movement Disorders

Received: 30 Apr 2019; Accepted: 06 Aug 2019.

Edited by:

Davide Martino, King's College London, United Kingdom

Reviewed by:

Alexandru Hanganu, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Canada
Matteo Bologna, Sapienza University of Rome, Italy  

Copyright: © 2019 Gracien, Petrov, Hok, van Weynen, Maiworm, Seiler, Deichmann and Baudrexel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Pavel Hok, Department of Neurology, Palacký University and University Hospital Olomouc, Olomouc, Czechia, pavel.hok@gmail.com