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Front. Neurol. | doi: 10.3389/fneur.2019.00987

Severe anti-NMDA receptor encephalitis despite immunosuppression after liver transplantation

  • 1Department of Neurology, Hannover Medical School, Germany

Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a patient in her 6th decade who developed anti-NMDA receptor encephalitis while being under adequate immunosuppressive therapy following liver transplantation. Although a broad spectrum of different immunotherapies was applied and anti-NMDA receptor antibody titers gradually decreased, the clinical course could not be affected positively. Autoimmune encephalitis after transplantation is only described in few cases and not well recognized. Our case adds further evidence for anti-NMDA receptor encephalitis as the cause of neuropsychiatric symptoms even under immunosuppressive therapy in a post-transplant setting.

Keywords: Epstein-Barr virus, anti-NMDA receptor encephalitis, Immunosuppression, Liver-transplantation, autoimmune encephalitis

Received: 12 Jul 2019; Accepted: 29 Aug 2019.

Copyright: © 2019 Konen, Schwenkenbecher, Jendretzky, Hümmert, Wegner, Stangel, Sühs and Skripuletz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Thomas Skripuletz, Department of Neurology, Hannover Medical School, Hannover, 30625, Lower Saxony, Germany, Skripuletz.Thomas@mh-hannover.de