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MINI REVIEW article

Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1389949
This article is part of the Research Topic Sleep Disorders in Neuromuscular Diseases: Treatable Conditions View all 4 articles

Excessive Daytime Sleepiness in Myotonic Dystrophy: A Narrative Review

Provisionally accepted
Domeniko Hoxhaj Domeniko Hoxhaj Alessia Pascazio Alessia Pascazio Giulia Ricci Giulia Ricci Monica Fabbrini Monica Fabbrini Francesca B. Torresi Francesca B. Torresi Gabriele Siciliano Gabriele Siciliano Enrica Bonanni Enrica Bonanni *
  • Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Tuscany, Italy

The final, formatted version of the article will be published soon.

    This review aims to provide a comprehensive analysis of excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 (DM1) and type 2 (DM2). EDS is a common and debilitating symptom in both forms of myotonic dystrophy, significantly impacting patients' quality of life. Polysomnographic studies have revealed a prominent dysregulation of REM sleep in DM1, suggesting a possible narcoleptic-like phenotype and alterations in NREM sleep, such as increased sleep instability and impaired delta power dissipation, that contributes to daytime sleepiness. While sleep-disordered breathing (SDB) and respiratory dysfunctions are prevalent in DM1 and DM2, their direct correlation with EDS remains complex and inconclusive. The review focuses on the purpose of examining the current understanding of EDS in these conditions, the difficulty in correctly accessing it, the recent findings related to its etiology and prevalence, and a summary of potential therapeutic implications.

    Keywords: neuromuscolar disorders, sleep disorder, myotonic distrophies, Sleepeness, Genetic disorder

    Received: 22 Feb 2024; Accepted: 08 May 2024.

    Copyright: © 2024 Hoxhaj, Pascazio, Ricci, Fabbrini, Torresi, Siciliano and Bonanni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Enrica Bonanni, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Tuscany, Italy

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