Neural Basis of Video Gaming: A Systematic Review
- 1Cognitive NeuroLab, Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain
- 2Laboratory for Neuropsychiatry and Neuromodulation, Massachusetts General Hospital, Boston, MA, USA
Background: Video gaming is an increasingly popular activity in contemporary society, especially among young people, and video games are increasing in popularity not only as a research tool but also as a field of study. Many studies have focused on the neural and behavioral effects of video games, providing a great deal of video game derived brain correlates in recent decades. There is a great amount of information, obtained through a myriad of methods, providing neural correlates of video games.
Objectives: We aim to understand the relationship between the use of video games and their neural correlates, taking into account the whole variety of cognitive factors that they encompass.
Methods: A systematic review was conducted using standardized search operators that included the presence of video games and neuro-imaging techniques or references to structural or functional brain changes. Separate categories were made for studies featuring Internet Gaming Disorder and studies focused on the violent content of video games.
Results: A total of 116 articles were considered for the final selection. One hundred provided functional data and 22 measured structural brain changes. One-third of the studies covered video game addiction, and 14% focused on video game related violence.
Conclusions: Despite the innate heterogeneity of the field of study, it has been possible to establish a series of links between the neural and cognitive aspects, particularly regarding attention, cognitive control, visuospatial skills, cognitive workload, and reward processing. However, many aspects could be improved. The lack of standardization in the different aspects of video game related research, such as the participants' characteristics, the features of each video game genre and the diverse study goals could contribute to discrepancies in many related studies.
Nowadays, video gaming is a highly popular and prevalent entertainment option, its use is no longer limited to children and adolescents. Demographic data on video gaming shows that the mean age of video game players (VGPs) (31 years old, as of 2014) has been on the rise in recent decades (Entertainment Software Association, 2014), and it is a common activity among young adults. Moreover, the increasing ubiquity of digital technologies, such as smart-phones and tablet computers, has exposed most of the population to entertainment software in the form of casual video games (VGs) or gamified applications. Therefore, an important segment of society, over 30% in tablet computers and 70% in smart phones, has been exposed to these technologies and can be considered now, in some form, casual gamers (Casual Games Association, 2013).
It is not uncommon to hear both positive and negative health claims related to VGs in the mass media. Most of the time, these are unverified and sensationalist statements, based on “expert” opinions, but lacking evidence behind them. On the other side, as VGs become more complex (due to improvements in computer hardware), they cater to audiences other than children, appealing to older audiences, and VGs have gained prevalence as a mainstream entertainment option. Consequently, the number of people who spend hours daily playing these kinds of games is increasing.
There is interest in knowing the possible effects of long-term exposure to VGs, and whether these effects are generally positive (in the shape of cognitive, emotional, motivation, and social benefits) (e.g., Granic et al., 2014) or negative (exposure to graphic violence, contribution to obesity, addiction, cardio-metabolic deficiencies, etc.) (e.g., Ivarsson et al., 2013; Turel et al., 2016). Moreover, VGs possess a series of intrinsic features which make them suitable for use in experimental procedures: they seem to increase participants' motivation better than tasks traditionally used in neuropsychology (e.g., Lohse et al., 2013) and, in the case of purpose-made VGs, they offer a higher degree of control over the in-game variables.
For all the reasons mentioned above, VGs have recently sparked more scientific interest. The number of publications that study or use some form of gaming has been increasing, since 2005, at a constant rate of 20% per year. While during the 90's around 15 VG-related articles were published per year, in 2015 that number was over 350 (see Figure 1).
Figure 1. Increasing trend in VG-related articles. Since 2005, the average annual growth is around 20%. (Source: MEDLINE).
However, the concept of VG is extremely heterogeneous and within the category we find a myriad of hardly comparable genres. The behavioral effects and the neural correlates derived from the use of VGs depend both on the nature of the VG, the exposition to the game (hours of game play, age of onset, etc.) (Kühn and Gallinat, 2014), and, to a large extent, the individual characteristics of each participant (Vo et al., 2011).
Furthermore, due to the popularity of VG genres where graphic violence is prevalent (shooters, survival horror, fantasy), many studies have chosen to focus on this variable. Therefore, there is a reasonable amount of scientific literature devoted to the study of violent behaviors and violence desensitization as a consequence of violence in VGs (e.g., Wang et al., 2009; Engelhardt et al., 2011). Lastly, in particular since the emergence of online VG play, there are concerns about the addictive properties of VGs, akin to gambling and substance abuse, consequently making it another recurrent topic in the literature (e.g., Young, 1998).
For the time being, this whole body of knowledge is a complex combination of techniques, goals and results. On one hand, there are articles which study the effects of VG exposure over the nervous system and over cognition (e.g., Green and Seitz, 2015); it seems that there is solid evidence that exposure to certain kinds of VGs can have an influence on behavioral aspects, and therefore, we should be able to appreciate changes in the neural bases (Bavelier et al., 2012a). Actually, assessing the cognitive and behavioral implications of VG exposure has already been the object of study in recent systematic reviews and meta-analysis that used neuropsychological tasks to measure the influence of these games in healthy individuals. This is highly relevant since they evaluate the possible transfer effects of VG training to wider cognitive domains, providing a global perspective on how experimental and quasi-experimental designs differ in the size of the effect depending on the cognitive function (Powers et al., 2013), and how aging interferes with cognitive training by means of computerized tasks (Lampit et al., 2014) and VGs (Toril et al., 2014; Wang et al., 2016). Knowledge obtained about transfer effects is very important since it allows us to establish a link between VGs and cognition, indirectly helping us understand its neural basis, which in this case acts as a bridge between them. From an applied perspective, this knowledge can be used to design more effective rehabilitation programs, especially those focusing on older populations, keeping the most useful components and reducing those which are shown to have less benefits.
On the other hand, VGs have been used as a research tool to study the nervous system. In this group of studies, it is common to find exposure to VGs as the independent variable, especially in most studies that use unmodified commercial VGs. However, it is not unusual to employ custom designed VGs, such as the widely used Space Fortress, where in-game variables can be fine-tuned to elicit certain mental processes in consonance with the research hypothesis (e.g., Smith et al., 1999; Anderson et al., 2011; Prakash et al., 2012; Anderson et al., 2015). Nevertheless, in both cases, the study of the VG exposure over the nervous system and the use of VGs as a research tool, VGs are used to obtain information about the underlying neural processes relevant to our research interest.
As yet there is no systematic review on this topic. The aim of this article is to gather all the scientific information referring to neural correlates of VGs and synthesize the most important findings. All articles mentioning functional and structural changes in the brain due to video gaming will be analyzed and information about the most relevant brain regions for each kind of study will be extracted; the main objective of many VG-related articles is not to study their neural correlates directly. Studies focusing on the addictive consequences or the effects of violence will be categorized independently.
Our final goal is to highlight the neural correlates of video gaming by making a comprehensive compilation and reviewing all relevant scientific publications that make reference to the underlying neural substrate related to VG play. This is the first effort in this direction that integrates data regarding VGs, neural correlates and cognitive functions that is not limited to action-VGs or cognitive training programs, the most frequently found research topics.
In order to structure reliably the gathered information in this systematic review, the guidelines and recommendations contained in the PRISMA statement (Liberati et al., 2009) have been followed.
All articles which included neural correlates (both functional and structural) and included VG play in the research protocol or studied the effects of exposure to VGs were included in the review. Both experimental and correlational studies were included. No restrictions regarding publication date were applied.
Healthy participants of any age and gender were considered. Studies include both naive and experienced VG participants. Participants that reported gaming addiction or met criteria for internet gaming disorder (IGD) were also included in the review owing to the interest in observing neural correlates in these extreme cases. Other pathologies were excluded in order to avoid confounding variables.
Articles employing several methodologies were included. These can be organized into three main groups: studies where naive participants were trained in the use of a VG against a control group, studies comparing experienced players vs. non-gamers or low-experience players, and studies comparing differential characteristics of two VG or two VG genres.
The primary outcome measures were any kind of structural and functional data obtained using neuroimaging techniques including computerized tomography (CT) scan, structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), magneto encephalography (MEG), transcranial direct current stimulation (tDCS), electroencephalogram (EEG), event-related potentials (ERP), event-related spectral perturbation (ERSP), steady state visually evoked potential (SSVEP), Doppler, and near-infrared spectroscopy (NIRS), following or related to VG use.
Academic articles were located using two electronic databases: MEDLINE and Web of Science, and by scanning reference lists in other studies in the same field. Only the results from these two databases are reported since results from other sources (Scopus, Google Scholar) did not provide any relevant new results. The search was not limited by year of publication and only articles published in English, Spanish, or French were considered for inclusion. The first studies relevant to the topic are from 1992, while the most recent studies included in this review were published in February 2016.
A systematic search was performed using a series of keywords which were expected to appear in the title or abstract of any study containing neural correlates of VGs. These keywords were grouped in two main categories. First of all, a group of keywords trying to identify articles which used VG as a technique or as a study goal. These keywords included search terms related to “video games” proper (in different orthographic variants), types of players (casual, core, and hardcore gamers) and references to serious gaming. In second place, two groups of keywords were used to detect articles which studied the neural basis: (1) keywords related to anatomical features, such as structural or functional changes, gray, or white matter (WM) volumes, cortical features, and connectivity and (2) keywords which mentioned the neuroimaging technique used to obtain that data, such as EEG, MRI, PET, or NIRS. (See Appendix)
Due to the large amount of results obtained by the previous search terms, strict exclusion criteria were applied to limit the final selection of studies. The same criteria were applied in a standardized way by two independent reviewers, and disagreements between reviewers were resolved by consensus. Due to high variability in the terminology and the diversity of keywords used in the search, a large number of false positive studies (65% of items found) appeared during the review process (see Figure 2).
By performing a search using standardized terms, a list of studies from the two databases was extracted. A large number of studies (62% of those that met the inclusion criteria) were found to be duplicates in both databases, so a careful comparison was made in order to merge the references.
No unpublished relevant studies were considered. Studies relevant to the topic but not published in peer-reviewed journals, such as conference posters and abstracts were considered.
Data Collection Process
All the relevant information was classified in a spreadsheet, according to the variables listed below. Variables related to violence and abuse of VGs were also categorized, since a significant portion of the studies focused on these behaviors. A small number of articles (n = 7) were found in sources other than the two databases, mainly through references in other articles.
For each study, the following data was extracted: (1) characteristics of the sample, including sample size, average age and range, inclusion and exclusion criteria, and gaming experience; (2) aim of the study, specially noting if it is focused on gaming abuse or exposure to violent content; (3) name and genre of the VG used during the study, if applicable; (4) study design; (5) main neuroimaging technique applied in the study, and whether the technique was applied while participants played; (6) functional and structural neural correlates observed in the study. Studies were then classified in several groups as to whether they provided structural or functional data, and whether they addressed violent or addictive aspects.
Moreover, in order to understand the outcomes derived from the neural correlates, most of the studies establish a connection between these correlates and their cognitive correspondence, either by directly measuring the outcomes using cognitive tasks and questionnaires, or by interpreting their results based on existing literature.
In the discussion section of this review, we attempted to summarize the main findings by associating the neural changes to their cognitive and behavioral correspondences. Whereas, in many cases the original articles provided their own explanation for the phenomena, we also worked on integrating the general trends from a cognitive perspective. We therefore indicate which studies provide and interpret empirical cognitive or/and behavioral data (non-marked), those which discuss cognitive or/and behavioral implications without assessing them (marked with *), and those which did not provide any cognitive nor behavioral information (marked with **).
The combined search of MEDLINE and Web of Science provided a total of 306 unique citations. Of these, 205 studies were discarded because they did not seem to meet the inclusion criteria after reviewing the abstract. The main reasons for exclusion were: being a review article (n = 22), absence of neural correlates (n = 70), presence of pathology in the participants (n = 65), not being related to VGs or using simple computerized tasks which could not be considered VGs (n = 69), testing of new technologies in which the brain correlates were a mere by-product (n = 25), articles focused on motor functions (n = 15), pharmacological studies (n = 2), and finally, articles in languages other than English, Spanish, or French (n = 18). Excluded articles often met more than one exclusion criteria. As mentioned in the eligibility criteria, an exception were those articles in which the pathology consisted of gaming overuse or addiction and articles which featured psychopathology and included groups of healthy participants from whom neural data was provided.
Fifteen extra articles that met the inclusion criteria were found after examining the contents and following the references in the previously selected studies. As expected, articles written in English comprised the vast majority; among the rest (8.9%), 10 of them (4.9%) were discarded from the review solely for language reasons. No unpublished relevant studies were considered. Studies relevant to the topic but not published in peer-reviewed journals, such as conference posters and abstracts were considered. Ultimately, a total of 116 studies were identified for inclusion in the review (see flow diagram in Figure 2).
Most studies (n = 100; 86.2%) provided functional data, while only 22 (18.9%) of them studied structural changes in the brain. A few (n = 6; 5.2%) provided both structural and functional data. A significant number of the studies focused their attention on excessive playing or VG addiction. That was the case for 39 (33.6%) of the reviewed articles, so we considered it appropriate to analyze them in their own category. Likewise, 16 studies (13.8%) focusing on the violent component of VGs were also placed in their own category. These categories were not always exclusive, but there was only one case where the two criteria were met. (See Table 1 for a breakdown by category).
Characteristics of Included Studies
Based on their methodology, studies in this review could be classified as experimental (n = 54; 46.6%), randomly assigning the participant sample to the experimental groups, and quasi-experimental (n = 62; 53.4%), where the groups were usually constructed according to the participants' characteristics. While studies involving excessive gaming almost always followed a quasi-experimental design comparing experienced gamers against low-experience VG players, articles studying normal gaming and the effects of violence exposure used both experimental and quasi-experimental designs. A fraction of the studies (n = 15; 13%), both experimental and quasi-experimental, compared the results to a baseline using a pretest-posttest design. That was the case for most studies involving a training period with VGs.
The cumulative sample included in this review exceeds 3,880 participants. The exact number cannot be known since participants could have been reused for further experiments and in some cases the sample size was not available. Most studies used adolescents or young adults as the primary experimental group, since that is the main demographic target for video gaming. In many cases, only male participants were accepted. In the cases where VG experience was compared, the criteria varied greatly. For the low video gaming groups, VG usage ranged from <5 h/week to none at all. For the usual to excessive VG groups, it could typically start at 10 h/week. In some cases, where the level of addiction mattered, the score in an addiction scale was used instead.
In more than half of the studies (n = 67; 57.8%) participants actually played a VG as part of the experimental procedure. In the rest, either neural correlates were measured in a resting-state condition or VG related cues were presented to the participants during the image acquisition.
Structural changes in the gray matter (GM) were measured in the form of volumetric changes, whereas WM was assessed using tractography techniques. Functional changes were typically measured comparing activation rates for different brain regions. Nearly half (n = 55; 47.4%) of the assessed studies used fMRI as the neuroimaging technique of choice, while other functional techniques remained in a distant second place. Functional connectivity was assessed in several studies employing resting-state measures. EEG in its multiple forms was also widely used (n = 32; 27.6%) to obtain functional data, either to measure activation differences across regions or in the form of event related potentials. (See Table 2 for a breakdown by neuroimaging technique).
The high variability in the study designs, participants and objectives meant we focused on describing the studies, their results, their applicability, and their limitations on a qualitative synthesis rather than meta-analysis.
Data regarding structural changes following VG use was available from 22 studies, fourteen of which provided structural data for more than 800 participants that had a normal VG use and included both VGPs and non-VGPs (see Table 3). The remaining eight studies examined aspects concerning the excessive or professional use of VG (see Table 4).
In studies dealing with healthy, non-addicted participants, eight studies used MRI to provide structural information for the GM, while six focused on the WM using diffusion tension imaging (DTI).
Three studies compared lifetime VG experience prior to the study, while the rest used a training paradigm where participants were exposed to a VG during the experimental sessions prior to the neuroimaging procedure and compared to a baseline. Seven studies provided WM integrity data using the DTI technique while the rest analyzed cortical thickness variations using regular structural MRI.
The most researched areas in studies examining volumetric differences found relevant changes in prefrontal regions, mainly the dorsolateral prefrontal cortex (dlPFC) and surrounding areas, superior and posterior parietal regions, the anterior cingulate cortex (ACC), the cerebellum, the insula, and subcortical nuclei, as well as the striatum and the hippocampus. In addition to this, structural connectivity studies observed changes in virtually all parts of the brain, such as in fibers connecting to the visual, temporal and prefrontal cortices, the corpus callosum, the hippocampus, the thalamus, association fibers like the external capsule, and fibers connecting the basal ganglia.
A 100 articles provided functional data combined with VG use. Of these, around half (n = 51) were studies which did not include violence or addiction elements (See Table 5). A third (n = 34) corresponded to articles aiming at understanding the neural bases of IGD (See Table 6), often drawing parallels with other behavioral addictions and trying to find biomarkers for VG addiction. The rest (n = 16) were devoted to study the effects of violence exposure in VGs (See Table 7). In total, these studies provided functional data for 3,229 experimental subjects, including control groups. Note that there is some overlap with the structural section, since a few (n = 6) studies provided both structural and functional data.
Table 5. Studies providing functional data dealing with healthy, non-expert participants, without violent content.
The rich diversity of methodologies and research goals means that the study of functional brain correlates covers practically all regions of the brain. The most studied areas are found in frontal and prefrontal regions and are concerned with high-order cognitive processes and motor/premotor functions. Activity changes in parietal regions, like the posterior and superior parietal lobe, relevant for diverse functions such as sensory integration and visual and attentional processing, are also a common find. The anterior and posterior cingulate cortices, together with other limbic areas, such as the amygdala, and the entorhinal cortex, display activity changes possibly as a consequence of learning and emotion processing and memory. Structures in the basal nuclei also have a prominent role, particularly the striatum, in studies related to VG addiction. Finally, we must not overlook a series of brain regions which do not appear as frequently, such as occipital and temporal cortices, the cerebellum, the thalamus, and the hippocampus, where distinctive activity patterns have also been observed as a result of VG play.
Due to the given amount of data provided in the reviewed articles, we decided to categorize all the information based on the cognitive functions which are associated with the neurophysiological correlates, rather than focusing on the main research goal for each study. Thus, the discussion has been grouped into six main sections: attention, visuospatial skills, cognitive workload, cognitive control, skill acquisition, and reward processing. These cognitive processes are not clearly independent since they present some degree of overlap. This is particularly relevant in the cases of cognitive workload, which may be linked to virtually any cognitive function, and attention, which is also closely related to cognitive control, among other functions. Nevertheless, after analyzing the literature, virtually all the articles included in this review focused on one or more of the mentioned cognitive functions in order to explain their findings. Thus, the proposed categories have sufficient presence in the literature to justify their use as separate domains for the study of cognition. While they should not be understood as independent aspects of cognition, the chosen categorization will allow a link between the underlying neural correlates and corresponding behavior to be easily established.
Within each one of the sections, structural and functional correlates are discussed according to their contributions to cognitive functioning, including possible inconsistencies between studies and the presence of transfer effects. Owing to the close link between VG violence, limbic and reward systems, and the possible abnormal reward mechanisms in addicted players, studies previously classified with violence in VGs and VG addiction are predominantly discussed in the reward processing section.
Attentional resources are one of the main cognitive domains in which VGs are involved and one of the most researched. The involvement of attentional networks during gameplay is closely related with other brain regions responsible for cognitive control, especially when more complex operations toward a specific goal are required. Many brain regions are involved in attention, particularly nodes in the dorsal frontoparietal system, mediating top-down attentional processes in goal-oriented behavior, but also nodes in the ventral network, responsible for bottom-up sensory stimulation (e.g., Vossel et al., 2014) dealing with those salient stimuli to which the player must pay attention.
There is evidence that VGPs display enhanced performance in a range of top-down attentional control areas, such as selective attention, divided attention, and sustained attention (Bavelier et al., 2012b). The ACC is an area that consistently shows functional activity during VG play due to its involvement as the main hub in top-down attentional processes (selective or focused attention) and goal-oriented behavior (e.g., Anderson et al., 2011*; Bavelier et al., 2012b).
Non-VGPs, compared to VGPs, showed greater frontoparietal recruitment, a source of selective attention, as task demands increased, showing that habitual gamers have more efficient top-down resource allocation during attentional demanding tasks (Bavelier et al., 2012a). That resource optimization effect can also be observed in attentional control areas, such as the right middle frontal gyrus (MFG), right superior frontal gyrus (SFG), and the ventromedial prefrontal cortex (vmPFC) (Prakash et al., 2012*). Functional connectivity changes in the attentional ventral stream, particularly in occipitotemporal WM, responsible for bottom-up reorienting toward novel stimuli, have also been observed as a result of VG training and were linked to cognitive improvement (Strenziok et al., 2014*). Integration between attentional and sensoriomotor functions has been observed in expert VGPs in the form of increased structural GM and functional connectivity in anterior and posterior insular sub regions where long-term exposure to attentional VG demands coordinated with the fine skills involved in using the VG controller may have resulted in plastic changes in these two regions that are respectively involved in attentional and sensoriomotor networks (Gong et al., 2015*).
Using electrophysiological techniques, it seems that VG play correlates with an increment of the frontal midline theta rhythm, associated with focused attention (Pellouchoud et al., 1999*), and increases with VG practice (Sheikholeslami et al., 2007**; Smith et al., 1999), both in an action and a puzzle VG, attributable to ACC activity. Likewise, amplitudes in the P200 (Wu et al., 2012), an early visual stimuli perceptual component, and P300 components (Mishra et al., 2011; Wu et al., 2012), which involved in early stages of decision-making, were also linked to top-down spatial selective attention improvements after training and lifetime exposure to action VG. Action VGPs and non-action VGPs seem to respond differently in the way they deploy attention to central and peripheral targets in visual attention tasks, as measured by the N2pc component (West et al., 2015), which is also linked to selective attention.
If we consider different VG genres, it seems that action VGs are better at improving selective attention than other slow-paced VGs such as role-playing games (RPG) (Krishnan et al., 2013), puzzle (Green and Bavelier, 2003), or strategy VGs (Tsai et al., 2013) which require high planning skills and other forms of proactive cognitive control. This is probably due to the extensive use of attentional systems, paired with precise timings that action VGs require. While these improved attentional skills are typically observed in habitual VGPs, it is possible to achieve long-lasting improvements as a result of a single VG training procedure (Anguera et al., 2013).
Visuospatial skills encompass processes that allow us to perceive, recognize, and manipulate visual stimuli, including visuomotor coordination and navigational skills, and VGs are predominantly interactive visual tasks.
The areas implicated in visuospatial processing have traditionally been classified along a visual ventral stream (responsible for object recognition) and a visual dorsal stream (responsible for spatial location). Both depart from the visual cortex, in the occipital lobe, and reach the posterior parietal cortex (dorsal stream) and the inferior temporal cortex (ventral stream). More recent proposals have refined that model, broadening the traditional conceptualization of the two-stream model (for further details see Kravitz et al., 2011). Among other nodes, the role of the hippocampus stands out for its function in higher order visual processing and memory (Kravitz et al., 2011; Lee A. C. H. et al., 2012).
Neural correlates related to visuospatial skills have been detected in relationship with structural volume enlargements of the right hippocampus (HC), both in long-term gamers and experimentally after a VG training period (Kühn et al., 2013; Kühn and Gallinat, 2014*). Increased hippocampal volumes were also found by Szabó et al. (2014**), although the authors do not attribute that effect to the VG training. The entorhinal cortex, associated with navigational skills (Schmidt-Hieber and Häusser, 2013), which together with the HC is involved in spatial memory (Miller et al., 2015), was also correlated with lifetime experience in logic/puzzle and platform VG (Kühn and Gallinat, 2014*).
Decreased activation in occipitoparietal regions, associated with the dorsal visuospatial stream (Goodale and Milner, 1992), has also been linked to improved visuomotor task performance, suggesting a reduction of the cognitive costs as a consequence of the VG training, dependent on the training strategy used in the VG (Lee H. et al., 2012). Earlier N100 latencies in the visual pathways are another feature found in long-term VGPs, which may contribute to faster response times in visual tasks after years of practice (Latham et al., 2013).
Reduced WM integrity in interhemispheric parietal networks for spatially-guided behavior could be another symptom for a decreased reliance on specific visuospatial networks after VG training as performance improved (Strenziok et al., 2013*). However, other studies found that increased WM integrity in visual and motor pathways was directly responsible for better visuomotor performance in long term VGPs (Zhang et al., 2015*). Despite these connectivity changes, brain functional differences between VGPs and non-VGPs do not always reflect performance in visuospatial skills, which were best predicted by non-visual areas (Kim Y. H. et al., 2015*).
Brain activation patterns depend on the cognitive demands of the environment and also on the associated level of workload (Vogan et al., 2016), which is directly related to the allocation of resources to the working memory and its associated attentional processes (Barrouillet et al., 2007). When we manipulate this variable and observe its neural correlates, it is likely that we are seeing the result of neural recruitment mechanisms as the cognitive demands increase (Bavelier et al., 2012a). VGs have often been employed to obtain cerebral measures of cognitive workload, given the ability to adjust many of their features, particularly in a purpose-made VG, such as the popular Space Fortress. Due to the nature of this task, it is likely that functional changes related to the manipulation of cognitive load appear along the attentional networks and in specific key nodes related to executive functions, mainly in prefrontal and parietal cortices.
Cognitive workload is not a unitary concept; some studies have been able to identify different activation patterns by manipulating the difficulty of a task (e.g., Anderson et al., 2011*). Namely, the number of stimuli appearing simultaneously on the screen and the complexity of each stimulus seem to elicit different responses from the brain. For instance, in the context of an air traffic control simulator, when directly manipulating the task difficulty by increasing the number of planes that a participant had to attend, the theta band power increased (Brookings et al., 1996). Theta band power also displayed higher power compared to a resting condition, and gradually increased during gameplay (Sheikholeslami et al., 2007**). The theta band seems to be directly related to the level of cognitive demand in a wide range of cognitive abilities, such as attention, memory, and visuospatial processes, although this finding is not universal and decreased theta band power has been observed as a feature of sustained attention. So it appears that it is both related to task complexity and levels of arousal and fatigue. On the other hand, beta band power seemed to be more associated with the complexity of the task, especially in frontal and central areas, likely indicating a qualitative change in the cognitive strategy followed by the participant or the type of processing done by the brain (Brookings et al., 1996).
Assessing cognitive workload with ERP shows that during VG play, amplitudes tend to correlate negatively with game difficulty in expert VGPs, with most ERP (P200, N200) having its maximum amplitude in frontoparietal locations, with the exception of the P300, being larger in parietal regions (Allison and Polich, 2008). This is consistent with previous literature about cognitive workload related to attention and working memory demands and ERP peak amplitude decrements (Watter et al., 2001).
Frontoparietal activity, linked to attentional processes, also exhibits recruitment effects as game difficulty increases, which also affects reaction times, making them slower (Bavelier et al., 2012a). As mentioned above, comparing habitual VGPs with non-VGPs, it appears that the former show less recruitment of frontoparietal networks when compared to the non-gamers, which could be attributed to their VG experience and the optimization of their attentional resources (Bavelier et al., 2012a). Increased blood flow in prefrontal areas like dlPFC was also associated with increasing cognitive demands related to attention, verbal and spatial working memory and decision making (Izzetoglu et al., 2004*).
The intensity of the events displayed in the VG was also linked with certain electrophysiological correlates. High intensity events, such as the death of the VG character, were associated with increased beta and gamma power when compared with general gameplay (McMahan et al., 2015).
During the course of a VG, the player can encounter many situations in which he has to use one of several possible actions. For instance, while playing a game, the player might be required to interrupt and quickly implement an alternate strategy, or manipulate a number of elements in a certain way in order to solve a puzzle and progress in the storyline. All these abilities can be characterized under the “umbrella” of cognitive control, which includes reactive and proactive inhibition, task switching and working memory (Obeso et al., 2013). These cognitive control aspects are key to overcoming the obstacles found the VG. In fact, they are frequently used in parallel (Nachev et al., 2008) in order to engage in goal-directed behavior. These processes have their neural substrate in the prefrontal cortex, supported by posterior parietal areas and the basal ganglia (Alvarez and Emory, 2006). Therefore, most changes regarding cognitive control observed after VG play will likely be detected in these regions.
Indeed, prefrontal regions are one of the brain areas in which GM volumetric changes have been observed as a result of a cognitive training with a VG, which is remarkable if we consider that the common VG training period spans from a few weeks to a couple of months. These regions, such as the dlPFC, determinant for cognitive control (Smith and Jonides, 1999), show volumetric changes that seem to correlate with VG performance and experience, likely as a result of the continuous executive demands found in a VG, such as attentional control and working memory (Basak et al., 2011). These volumetric changes even result in correlations with transfer effects in cognitive control tasks (Hyun et al., 2013). Volumetric-behavioral correlations work both ways, since individuals with decreased orbitofrontal cortex (OFC) volumes as a consequence of VG addiction show poorer performance in similar tasks (Yuan et al., 2013a).
During VG play, these prefrontal regions increase their activation in response to the cognitive demands (game difficulty) and display a positive correlation with performance measures (Izzetoglu et al., 2004*). Still, prefrontal activity is not only affected by the complexity of the task, but also by the nature of the task and the individual differences of the participants (Biswal et al., 2010). Some research groups have found deactivation of dorsal prefrontal regions during gameplay. A possible explanation for this phenomenon could be the interference effect of attentional resources during visual stimuli, since activity in the dlPFC remained stable while passively watching a VG, but not while actively playing it (Matsuda and Hiraki, 2004*). Likewise, the same team also found that finger movement while handling the game controller did not seem to contribute as a source of prefrontal deactivation. Further studies also noted that the observed prefrontal deactivation was not affected by age or performance level (Matsuda and Hiraki, 2006*), although some authors have challenged that finding, claiming that prefrontal activation during video gaming was age-dependent, where most adults tended to show increased prefrontal activity while it was attenuated in some of the children. So prefrontal activation could be a result of age, game performance, level of interest and attention dedicated to the VG (Nagamitsu et al., 2006**).
It has been possible to establish a causal relationship between dlPFC activation and cognitive control using non-invasive stimulation methods. Stimulating the left dlPFC using tDCS results in a perceptible improvement in multitasking performance in a three-dimensional VG (Hsu et al., 2015).
Changes in functional activity after a training period in other executive-related nodes, such as the superior parietal lobe (SPL) have also been associated with working memory improvements (Nikolaidis et al., 2014).
Connectivity-wise, Martínez et al. (2013) found resting-state functional connectivity changes in widespread regions (frontal, parietal, and temporal areas) as a result of a VG training program, which were attributed to the interaction of cognitive control and memory retrieval and encoding.
Despite the observed structural and functional changes in prefrontal areas, executive functions trained in a VG show poor transfer effects as measured with cognitive tasks (Colom et al., 2012; Kühn et al., 2013). Others, showing neural correlates related to executive functions, visuospatial navigation and fine motor skills, failed to observe far transfer effects even after a 50 h training period, as measured by neuropsychological tests (Kühn et al., 2013). By studying lifelong experts or professional gamers, some studies have detected structural GM changes that correlated with improved executive performance, involving posterior parietal (Tanaka et al., 2013), and prefrontal (Hyun et al., 2013) regions. Regarding structural connectivity, WM integrity changes in thalamic areas correlated with improved working memory, but integrity of occipitotemporal fibers had the opposite effect (Strenziok et al., 2014). VG experience also seems to consolidate the connectivity between executive regions (dlPFC and the posterior parietal cortex -PPC-) and the salience network, composed by the anterior insula and the ACC, and responsible for bottom-up attentional processes (Gong et al., 2016).
Different VG genres seem to affect which cognitive skills will be trained. Training older adults in a strategy VG seemed to improve verbal memory span (McGarry et al., 2013), but not problem solving or working memory, while using a 2D action VG improved everyday problem solving and reasoning. Transfer effects were even more relevant in the case of a brain training/puzzle VG, where working memory improvements were also observed (Strenziok et al., 2014). Using a younger sample, working memory improvements were detected after training with a 2D action VG (Space Fortress, Nikolaidis et al., 2014). Nevertheless, training periods found in scientific literature vary greatly and it is difficult to ascertain if a lack of transferred skills cannot be due to a short training period.
Regarding electrophysiological methods, electroencephalography studies have shown functional correlations with alpha oscillations in the frontal cortex that could reflect cognitive control engagement in the training VG (Mathewson et al., 2012).
Several studies have attempted to determine which regions could act as predictors for skill acquisition. Since this is a domain in which multiple cognitive functions are involved, volumetric and functional changes will appear in a wide range of cortical regions. Most of the learning in VGs is non-declarative, including visuospatial processing, visuomotor integration, and motor planning and execution. Improvements in these areas will generally lead to decreased cortical activation in the involved areas due to the optimization of resources, whereas this is not the case for striatal and medial prefrontal areas, which display a distinctive pattern of activation and typically increase their activity due to skill acquisition (Gobel et al., 2011).
Striatal volumes were determined as predictors for skill acquisition, although structural changes in the hippocampal formation were not (Erickson et al., 2010). Particularly, the anterior half of the dorsal striatum was the region which more accurately predicted skill acquisition in a complex VG (Vo et al., 2011). Other areas identified as predictors were the medial portion of the Brodmann area 6, located in the frontal cortex and associated with motor control in cognitive operations and response inhibition and the cerebellum, likely associated with motor skill acquisition (Basak et al., 2011). The same authors also considered the post-central gyrus, a somatosensory area that could be related to a feedback mechanism between prefrontal and motor regions, while the volume of the right central portion of the ACC also correlated with skill acquisition and is responsible for monitoring conflict. Finally, dlPFC volumes, with a central role on the executive functions, also showed correlation with VG performance over time (Basak et al., 2011).
On a functional level, Koepp et al. (1998**) was the first team to identify a relationship between striatum activity, associated with learning and the reward system, and performance level in a VG. The study by Anderson et al. (2015) also support the notion that the striatum, particularly the right dorsal striatum, composed of the caudate nucleus and the claustrum, is a key area in skill acquisition. However, the same team was able to predict learning rates more accurately by comparing whole sequential brain activation patterns to an artificial intelligence model.
Learning gains seemed to be best predicted by individual differences in phasic activation in those regions which had the highest tonic activation (Anderson et al., 2011*). Differences related to learning rates were also observed in the activation of the default mode network, especially when different training strategies were employed by the participants. Using electrophysiological methods, the best predictors were the alpha rhythms (Smith et al., 1999), particularly frontal regions, and alpha and delta ERSP, which are associated with cognitive control (task switching and inhibition) and attentional control networks (Mathewson et al., 2012). Frontal midline theta rhythms, linked with focused concentration and conscious control over attention, seemed to increase over the course of the training sessions with a VG (Smith et al., 1999).
VG addiction is understood as an impulse-control disorder with psychological consequences, not unlike other addictive disorders, especially non-substance addictions such as pathological gambling (Young, 1998). Internet Gaming Disorder (IGD) has been recently proposed for inclusion as a psychiatric diagnosis under the non-substance addiction category in the Diagnostic and Statistical Manual for Mental Disorders 5th ed. (DSM-5) (American Psychiatric Association, 2013), with its diagnostic criteria being adapted from those of pathological gambling. Efforts in order to find a consensus regarding its assessment are still ongoing (Petry et al., 2014). In some cases, VG addiction is included as a subset within the broader definition of Internet addiction, although this categorization is not always consistent, since many VGs in which addiction is studied do not have an online component. Several instruments have been developed to assess gaming addictions: the Internet Addiction Test (IAT) by Young (1998) and the Chen Internet Addiction Scale (CIAS) (Chen et al., 2004) being the most used in research and clinical practice.
Within the VG literature, there is a great deal of interest in knowing the neurobiological basis of VG addiction and whether it can be related to other behavioral addictions by observing abnormal reward processing patterns. This seems to be the case, since many regions involved in the reward system have been found affected in people with VG addiction (e.g., Liu et al., 2010*; Hou et al., 2012*; Hahn et al., 2014). Among the complex set of structures that are involved in the reward system, the cortico-ventral basal ganglia circuit is the center of the network responsible for assessing the possible outcomes of a given behavior, especially in those situations where, during a goal-oriented behavior, complex choices must be made and the value and risk of secondary rewards must be weighed (Haber, 2011).
Differential structural and functional changes in addicted individuals can be found throughout the reward system. The main components of this circuit are the OFC, the ACC, the ventral striatum, ventral pallidum, and midbrain dopaminergic neurons (Haber, 2011), but many other regions seem to be involved in the wider context of addiction.
By exposing the participants to gaming cues, it is possible to elicit a craving response and study which regions show stronger correlation in IGD patients compared to controls. The model proposed by Volkow et al. (2010) involves several regions, which are mentioned consistently across studies, to explain the complexity of the craving. First, the precuneus, which showed higher activation in addicted individuals (Ko et al., 2013*), is an area associated with attention, visual processes, and memory retrieval and integrates these components, linking visual information (the gaming cues) to internal information. Regions commonly associated with memory and emotional functions are also involved: the HC, the parahippocampus and the amygdala seem responsible for providing emotional memories and contextual information for the cues (Ding et al., 2013*), regions where subjects showed higher activation (O'Brien et al., 1998). Central key regions of the reward system, like the limbic system and the posterior cingulate have a role in integrating the motivational information and provide expectation and reward significance for gaming behaviors (O'Doherty, 2004). The OFC and the ACC are responsible for the desire for gaming and providing a motivational value of the cue-inducing stimuli (Heinz et al., 2009), contributing to the activation and intensity of the reward-seeking behavior (Kalivas and Volkow, 2005; Brody et al., 2007; Feng et al., 2013*). In the last step, prefrontal executive areas such as the dlPFC have also shown involvement during craving responses (Han et al., 2010a*; Ko et al., 2013*), and are linked to the formation of behavioral plans as a conscious anticipation of VG play. All these frontal regions[dlPFC, OFC, ACC, and the supplementary motor area (SMA)] tend to show reduced GM volumes in participants with IGD (Jin et al., 2016*).
Striatal volumes, particularly the ventral striatum, responsible for a key role in reward prediction, were reduced in people with excessive internet gaming compared to healthy controls (Hou et al., 2012*) and in the insula, with its role in conscious urges to abuse drugs (Naqvi and Bechara, 2009).
Overall, these features are characteristic of reward deficiencies that entail dysfunctions in the dopaminergic system, a shared neurobiological abnormality with other addictive disorders (Ko et al., 2009*, 2013*; Cilia et al., 2010; Park et al., 2010; Kim et al., 2011).
Several regions seem to be related to the intensity of the addiction. In a resting state paradigm, connectivity between the left SPL, including the posterior cingulate cortex (PCC), and the right precuneus, thalamus, caudate nucleus, nucleus accumbens (NAcc), SMA and lingual gyrus (regions largely associated with the reward system) correlated with the CIAS score, while at the same time, functional connectivity with the cerebellum and the superior parietal cortex (SPC) correlated negatively with that score (Ding et al., 2013*). The distinctive activation and connectivity patterns related to the PCC (Liu et al., 2010*), an important node in the DMN and reward system (Kim H. et al., 2015), could be used as a biomarker for addiction severity, both in behavioral and substance dependence. As the addiction severity increases, changing from a voluntary to a compulsive substance use, there is a transition from prefrontal to striatal control, and also from a ventral to a dorsal striatal control over behavior (Everitt and Robbins, 2005), Matching evidence in the form of weaker functional connectivity involving the dorsal-caudal putamen has been found in IGD patients (Hong et al., 2015*).
It is important to note that, even controlling the amount of time playing VGs, professional and expert gamers display very different neural patterns compared to addicted VGPs. Gamers falling into the addiction category show increased impulsiveness and perseverative errors that are not present in professional gamers and, on a neural level, they differ in GM volumes in the left cingulate gyrus (increased in pro-gamers) and thalamus (decreased in pro-gamers), which together may be indicative of an unbalanced reward system (Sánchez-González et al., 2005; Han et al., 2012b).
Exposure to Violent Content
Many articles use violent VGs in their designs as a way to study the effects of violence exposure, emotional regulation and long-term desensitization. Exposure to violent content has been associated with reduced dlPFC activity and interference in executive tasks (inhibition, go/no-go task) (Hummer et al., 2010), which cannot be interpreted without studying the link with the limbic and reward systems. It is likely that repeated exposure to violent content will trigger desensitization processes that affect regions linked to emotional and attentional processing, particularly a frontoparietal network encompassing the left OFC, right precuneus and bilateral inferior parietal lobes (Strenziok et al., 2011). It is hypothesized that this desensitization may result in diminished emotional responses toward violent situations, preventing empathy and lowering the threshold for non-adaptive behaviors linked to aggressiveness (Montag et al., 2012).
Limbic areas are associated with violence interactions, shown by the activation changes detected in the ACC and the amygdala in the presence of violent content (Mathiak and Weber, 2006*; Weber et al., 2006*). Lateral (especially left) prefrontal regions might be involved as well, integrating emotion and cognition and therefore working as a defense mechanism against negative emotions by down-regulating limbic activity (Montag et al., 2012). Wang et al. (2009) also provided evidence of that regulation mechanism by observing differing functional correlations between the left dlPFC and the ACC, and medial prefrontal regions & the amygdala during an executive task after a short-term exposure to a violent VG.
The reward circuit also seems to be implicated in the presence of violent content. Activation decreases in the OFC and caudate appeared in the absence of an expected reward. However, it does not seem that violence events were intrinsically rewarding (Mathiak et al. (2011*). Zvyagintsev et al. (2016*) found that resting-state functional connectivity was reduced within sensory-motor, reward, default mode and right frontotemporal networks after playing a violent VG, which could be linked to short-term effects on aggressiveness.
Gender differences in neural correlates were observed in one study (Chou et al., 2013*) after being exposed to violent content, with reduced blood flow in the dorsal ACC after playing a violent VG in males, but not females, possibly as a result of the role of the ACC in regulating aggressive behavior in males.
The effect of certain personality traits, particularly empathy, have been assessed using violent VG exposure (Lianekhammy and Werner-Wilson, 2015*). However, while empathy scores correlated with neural activity (frontal asymmetry during EEG), they were not affected by the presence of violent content. Markey and Markey (2010) found that some personality profiles, especially those with high neuroticism and low conscientiousness and agreeableness, are more prone to be affected by the exposure to violent VGs.
VG player's perspective may also be determinant to the level of moral engagement; while ERP N100 amplitudes were greater during a first person violent event, if the player was using a distant perspective, general alpha power was greater, which is indicative of lower arousal levels (Petras et al., 2015).
Montag et al. (2012), observed that regular gamers have been habituated to violence exposure and show less lateral prefrontal activation, linked to limbic down-regulation, compared to non-gamers. However, gamers have not lost the ability to distinguish real from virtual violence, as Regenbogen et al. (2010*) found, although that also depended on each person's learning history.
While attenuated P300 amplitudes have been linked to violence desensitization, both in short and long term exposure (Bartholow et al., 2006), these amplitudes did not increase using a pro-social VG (Liu Y. et al., 2015). Engelhardt et al. (2011), experimentally linked the lower P300 amplitudes to violence desensitization and their effects on aggression. Bailey et al. (2010) also supported the link between violent VG exposure and desensitization to violent stimuli, associating it with early processing differences in attentional orienting.
Flow and boredom states during VG play have also been the subject of research using neural correlates. The concept of flow, described by Csikszentmihalyi (1990), is understood as a mind state of being completely focused on a task that is intrinsically motivating. Among other characteristics, the state of flow implies a balance between the task difficulty and the person's skills, the absence of ambiguity in the goals of the task, and is commonly accompanied by a loss of awareness of time. Considering that the concept of flow is a complex construct which itself cannot be directly measured, it is necessary to operationalize its components. Some authors have identified some of these components as sustained attention (focus), direct feedback, balance between skill and difficulty, clear goals and control over the activity (Klasen et al., 2012*) and it has been theorized to be firmly linked to attentional and reward processes (Weber et al., 2009).
VGs provide the appropriate context in which flow states are encouraged to occur, since feedback is offered continuously and the level of difficulty is programmed to raise progressively, in order to match the improving skills of the player (Hunicke, 2005; Byrne, 2006). Therefore, VGs are perfect candidates to operationalize the components involved in the flow theory.
During gameplay in an action VG, Klasen et al. (2012*) could not relate the feedback component to any meaningful neural activity, but the four remaining flow-contributing factors showed joint activation of somatosensory networks. Furthermore, motor regions were implicated in the difficulty, sustained attention and control components. Together, the authors identify this sensorimotor activity as a reflection of the simulated physical activity present in the VG, which can contribute to the state of flow. The rest of the components elicited activity in several different regions. The reward system was involved in the skill-difficulty balance factor, observed by activation in the ventral striatum and other basal nuclei, rewarding the player in successful in-game events. In addition to activity in reward regions, this factor also correlated with simultaneous activity in a motor network comprised of the cerebellum and premotor areas. The factor comprising concentration and focusing during the VG was associated with changes in attentional networks and the visual system, as players switched away from spatial orientation to processing the numerous elements of the VG in high focus settings. Goal-oriented behavior showed decreased activity in the precuneus and regions of the ACC, while activity in bilateral intraparietal sulcus and right fusiform face area (associated with face processing) increased, which the authors explain as a result of a shift from navigation in a known environment to seeking new game content (Klasen et al., 2012*).
When manipulating the VG settings to elicit states or boredom, operationalized as the absence of goal-oriented behavior, one of the main aspects of flow, affective states appear. While the lack of goal-directed behavior resulted in an increase of positive affect, the neural correlates were characterized by lower activation in the amygdala and the insula (Mathiak et al., 2013). However, a different neural circuit was responsible when negative affect increased, characterized by activation in the ventromedial prefrontal cortex and deactivation of the HC and the precuneus, that seemed to counteract the state of boredom, possibly by planning future actions during inactive periods (Mathiak et al., 2013). Involvement of frontal regions was also observed by Yoshida et al. (2014) related to flow and boredom states. During the state of flow, activity in bilateral ventrolateral prefrontal cortex (vlPFC) [comprising the inferior frontal gyrus (IFG) and lateral OFC] increased, and it decreased when participants were subject to a boredom state. The OFC is linked to reward and emotion processing (Carrington and Bailey, 2009), and monitoring punishment (Kringelbach and Rolls, 2004). However, this study employed boredom differently, using a low difficulty level in the VG instead of the suppressing goal-directed behavior.
Brain-computer interfaces, using electrophysiological methods to measure brain activity, have been able to differentiate states of flow and boredom, created by adjusting the level of difficulty of a VG. The EEG frequencies that were able to discern between flow states were in the alpha, low-beta and mid-beta bands, measured in frontal (F7 and F8) and temporal (T5 and T6) locations (Berta et al., 2013).
Although some studies have already discussed the presence of gender differences in cognitive processes related to VG playing, the lack of studies dealing with this topic and providing neural data are notable. The most relevant study of gender differences (Feng et al., 2007*) found that a 10-h training in an action VG (but not in a non-action VG) was enough to compensate for baseline gender differences in spatial attention, and to reduce the gap in mental rotation skills. Whether the initial difference was innate or a product of lesser exposure to this kind of activities in women is a matter of debate (Dye and Bavelier, 2010). Actually, one of the reasons men do not improve as much as women could be explained by a ceiling effect due to previous exposure to VGs. On the other hand, women with less experience in these activities are able to achieve equal performances in visuospatial skills that reach the same ceiling effect with a short training period. In this respect, Dye and Bavelier comment on the possible effects of lifetime VG exposure since the gender gap in attentional and non-attentional skills is smaller or non-existent during childhood compared to adult life, and the greater development of these skills in male individuals is partially due to games targeting a male audience.
Other authors (Ko et al., 2005) have focused on other psychosocial factors to explain gender differences in online VG addictions. Considering most online VGPs are men and this difference is also observed in addiction cases, they studied the possible factors and observed that lower self-esteem and lower daily life satisfaction are determinant in men, but not women. They attribute these differences to the reasons on why they play VGs: while men declared to play to pursue feelings of achievement and social-bonding, it was not the case for women. This aspect is not new to VG addiction and is shared aspect with other addictions. It is likely that VGs are used as a way to cope with these problems, leading up to the development of the addiction.
The study of neural correlates of VGs entails a number of inherent difficulties. The main limitation encountered during the development of this review was the dual nature of studies with regard to VGs as a research tool or as an object of study. The lack of standardization in study objectives is another limitation that should be addressed. Despite the recent popularity of VG-related studies, there are a multitude of similar research lines that offer hardly comparable results, making it difficult to draw general conclusions. We aimed to unify all sorts of studies in order to interpret and generalize the results.
First of all, we compared a large number of studies that not only used completely different techniques, but also had very heterogeneous research goals. We grouped them together with the aim of extracting all the available neuroimaging information, but it is likely that some information that would have been relevant for us was missed in the studies because their research objectives differed greatly from our own. In fact, in certain cases, VGs were almost irrelevant to the aim of the study and were only used as a substitute for a cognitive task, so the provided results may not directly reflect the VG neural correlates. Similarly, VGs were sometimes used as tools to provide violence exposure or to study the effects of behavioral addictions without the VG being the central object of study.
Another issue was the lack of a proper classification for VG genres. While the most common division is between action and non-action VGs, it would be interesting to establish which variables determine this classification. For instance, both first person shooters and fighting games could be considered action VGs. Both demand quick response times and high attentional resources, but first person shooter games require much higher visuospatial skills while fighting games do not. Consequently, efforts should be made to determine which aspects of each VG genre are related with each cognitive process and its associated neural correlates.
Apart from these aspects, comparisons between gamers and non-gamers are common in VG literature. Nevertheless, there is no consensus on the inclusion requirements for each group and it seems that no scientific criterion has been used to establish a cut-off line. Current dedication to VGs, measured in hours per week, seems to be the most common classification method. Non-gamer groups sometimes are so strict as to exclude any gaming experience, but on other occasions, for the same category, several weekly VG hours are tolerated. This is problematic since, in some cases, cognitive changes have been found after just a few weeks of VG training. However, in most cases, the onset age of active VG play, which is a particularly relevant aspect (Hartanto et al., 2016), is not taken into account. Another relevant variable, which tends to be forgotten, is lifetime VG experience, usually measured in hours. Moreover, despite the clearly different outcomes caused by different VG genres, this variable is not included when describing a participant's VG experience. Therefore, VG experience should be measured taking into account all the variables mentioned above: onset age, lifetime VG experience (in hours), current VG dedication (hours per week) and VG genres.
With regard to this review, it was really difficult to extract all the relevant information because of the limitations of the existing literature about the topic. But we did our best to clarify the results and to extract valuable conclusions.
Another limitation was the link between neural changes and cognitive functions. The neural correlates of VGs are the focus of this review, and we found it essential to complement this data by discussing their cognitive implications. In most cases these implications were directly assessed by the individual studies, but in some cases they were extrapolated based on previous literature. Furthermore, even when functional or structural changes are detected, they do not always reflect cognitive changes. This may be due to a lack of sensitivity in the cognitive and behavioral tasks employed. In order to detect both neural and cognitive changes, specific research designs, with sufficiently sensitive measurements of the three dimensions (functional, structural, and cognitive) are needed. Ideally, to determine when each change starts to appear as a result of VG exposure, an experimental design, including a VG training period, should be used. In this design, the neural and cognitive data would be assessed along a series of time points until the three types of changes were detected. An exhaustive discussion of the cognitive implications of VGs is beyond our scope since there are already other works that deal with this particular issue (Powers et al., 2013; Lampit et al., 2014; Toril et al., 2014; Wang et al., 2016).
Efforts should be made to systematize VG-related research, establishing VG training protocols and determining the effects of lifetime VG exposure, in order that more comparable results can be obtained and to improve the generalizability of results.
The current work has allowed us to integrate the great deal of data that has been generated during recent years about a topic that has not stopped growing, making it easier to compare the results of multiple research groups. VG use has an effect in a variety of brain functions and, ultimately, in behavioral changes and in cognitive performance.
The attentional benefits resulting from the use of VG seem to be the most evidence-supported aspect, as many studies by Bavelier and Green have shown (Green and Bavelier, 2003, 2004, 2006, 2007, 2012; Dye et al., 2009; Hubert-Wallander et al., 2011; Bavelier et al., 2012b). Improvements in bottom-up and top-down attention, optimization of attentional resources, integration between attentional and sensorimotor areas, and improvements in selective and peripheral visual attention have been featured in a large number of studies.
Visuospatial skills are also an important topic of study in VG research, where optimization of cognitive costs in visuomotor task performance is commonly observed. Some regions show volumetric increases as a result of VG experience, particularly the HC and the entorhinal cortex, which are thought to be directly related to visuospatial and navigational skills. Optimization of these abilities, just like in attention and overall skill acquisition, is usually detected in functional neuroimaging studies as decreased activation in their associated pathways (in this case, in regions linked to the dorsal visual stream). It is likely that the exposure to a task first leads to an increase of activity in the associated regions, but ultimately, as the performance improves after repeated exposures, less cortical resources are needed for the same task.
Likewise, although not always consistent, even short VG training paradigms showed improvements in cognitive control related functions, particularly working memory, linked to changes in prefrontal areas like the dlPFC and the OFC. How to achieve far transfer in these functions remains one of the most interesting questions regarding cognitive control. Despite VGs being good candidates for cognitive training, it is still not well-known what the optimum training parameters for observing the first effects are. It seems intuitive that longer training periods will have a greater chance of inducing far transfer, but how long should they be? We also commented on how VG genre can have differential effects on cognitive control, so we cannot expect to observe these effects without first controlling this variable, since different VG genres often have little in common with each other.
Cognitive workload studies have offered the possibility of observing neural recruitment phenomena to compensate for the difficulty and complexity of a cognitive task and a number of studies have pointed to the importance of frontoparietal activity for this purpose.
It has been also possible to link skill acquisition rates with certain cerebral structures. Several brain regions are key in this regard, mainly the dlPFC, striatum, SMA, premotor area, and cerebellum. Moreover, as suggested by Anderson et al. (2015), models of whole-brain activation patterns can also be used as an efficient tool for predicting skill acquisition.
The role of the reward system is always present when we talk about VGs, due to the way they are designed. Addiction has a heavy impact throughout the neural reward system, including components like the OFC, the ACC, the ventral striatum, ventral pallidum, and midbrain dopaminergic neurons, together with diverse regions that have support roles in addiction. The role of structures that link addiction to its emotional components, such as the amygdala and the HC should not be underestimated. Limbic regions work together with the PCC to integrate the motivational information with the expectation of reward.
Exposure to violent content has implications regarding the reward circuits and also emotional and executive processing. Reduced functional connectivity within sensory-motor, reward, default mode and right frontotemporal networks are displayed after playing a violent VG. The limbic system, interacting with the lateral prefrontal cortex, has a role in down-regulating the reaction to negative emotions, like those found in violent contexts, which may lead to short-term violence desensitization.
Despite the difficulties in locating the main components of flow in the brain, it seems that several networks are involved in this experience. General activation of somatosensory networks is observed while being in this state, whereas activation in motor regions is only linked to three components of flow: skill-difficulty balance, sustained attention and control over the activity. The reward system has key implications in the experience of flow, showing that the ventral striatum and other basal ganglia are directly linked to the skill-difficulty balance in a task. When seeking new content in order to avoid boredom, the bilateral intraparietal sulcus and the right fusiform face area seem to be the most implicated regions. During a flow-evoking task, the absence of boredom is shown by activity in the IFC, the OFC, and the vmPFC. Flow is also linked to emotional responses, and both positive and negative affect during a VG have shown changes in the amygdala, insula, vmPFC and the HC.
It is also worth commenting on the negative effects of VGs. While much has been written about the possible benefits of VG playing, finding articles highlighting the negative outcomes in non-addicted or expert VGPs is much less common. To our knowledge, only four studies pointed out neural correlates which predicted hindered performance in a range of cognitive domains. VG use has been linked with reduced recruitment in the ACC, associated with proactive cognitive control and possibly related to reduced attentional skills (Bailey et al., 2010). Likewise, exposure to violent content in VG is associated with lower activity in the dlPFC, interfering with inhibitory control. The same team (Bailey and West, 2013) observed how VG play had beneficial effects on visuospatial cognition, but in turn had negative effects on social information processing. Lastly, VG exposition has been linked to delayed microstructure development in extensive brain regions and lower verbal IQ (Takeuchi et al., 2016).
Finally, although this review is focused on the neural correlates of VG, not their cognitive or behavioral effects, we believe in the importance of integrating all these aspects, since raw neuroimaging data often offer little information without linking it to its underlying cognitive processes. Despite the fact that this integration is increasingly common in the literature, this is not always the case and it is an aspect that could be addressed in future studies.
All authors had an equal involvement during the process of making this review article. The article's design, data acquisition, and analysis of its content has been made by consensus among all the authors.
This study has been supported by the doctoral school of the Open University of Catalonia, Spain, under the IN3-UOC Doctoral Theses Grants Programme 2013-2016 (http://in3.uoc.edu). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The reviewer JMRA and handling Editor declared their shared affiliation, and the handling Editor states that the process nevertheless met the standards of a fair and objective review.
We would like to sincerely thank our colleague Cristina García Palma for her assistance during the whole process of extracting and processing information from the scientific databases and for her valuable contributions during the course of this work. We would also like to express our gratitude to Nicholas Lumsden, who assisted in the proof-reading and English-language correction of the manuscript.
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/article/10.3389/fnhum.2017.00248/full#supplementary-material
Allison, B. Z., and Polich, J. (2008). Workload assessment of computer gaming using a single-stimulus event-related potential paradigm. Biol. Psychol. 77, 277–283. doi: 10.1016/j.biopsycho.2007.10.014
Anderson, J. R., Bothell, D., Fincham, J. M., and Moon, J. (2015). The Sequential structure of brain activation predicts skill. Neuropsychologia 81, 94–106. doi: 10.1016/j.neuropsychologia.2015.12.014
Anderson, J. R., Bothell, D., Fincham, J. M., Anderson, A. R., Poole, B., and Qin, Y. (2011). Brain regions engaged by part- and whole-task performance in a video game: a model-based test of the decomposition hypothesis. J. Cogn. Neurosci. 23, 3983–3997. doi: 10.1162/jocn_a_00033
Anguera, J. A., Boccanfuso, J., Rintoul, J. L., Al-Hashimi, O., Faraji, F., Janowich, J., et al. (2013). Video game training enhances cognitive control in older adults. Nature 501, 97–101. doi: 10.1038/nature12486
Bailey, K., West, R., and Anderson, C. A. (2010). A negative association between video game experience and proactive cognitive control. Psychophysiology 47, 34–42. doi: 10.1111/j.1469-8986.2009.00925.x
Bailey, K., West, R., and Anderson, C. A. (2011). The association between chronic exposure to video game violence and affective picture processing: an ERP study. Cogn. Affect. Behav. Neurosci. 11, 259–276. doi: 10.3758/s13415-011-0029-y.
Barrouillet, P., Bernardin, S., Portrat, S., Vergauwe, E., and Camos, V. (2007). Time and cognitive load in working memory. J. Exp. Psychol. Learn. Mem. Cogn. 33, 570–585. doi: 10.1037/0278-73188.8.131.520
Bartholow, B. D., Bushman, B. J., and Sestir, M. A. (2006). Chronic violent video game exposure and desensitization to violence: behavioral and event-related brain potential data. J. Exp. Soc. Psychol. 42, 532–539. doi: 10.1016/j.jesp.2005.08.006
Basak, C., Voss, M. W., Erickson, K. I., Boot, W. R., and Kramer, A. F. (2011). Regional differences in brain volume predict the acquisition of skill in a complex real-time strategy videogame. Brain Cogn. 76, 407–414. doi: 10.1016/j.bandc.2011.03.017
Bavelier, D., Green, C. S., Pouget, A., and Schrater, P. (2012b). Brain plasticity through the life span: learning to learn and action video games. Annu. Rev. Neurosci. 35, 391–416. doi: 10.1146/annurev-neuro-060909-152832
Berta, R., Bellotti, F., De Gloria, A., Pranantha, D., and Schatten, C. (2013). Electroencephalogram and physiological signal analysis for assessing flow in games. IEEE Trans. Comput. Intell. AI Games 5, 164–175. doi: 10.1109/TCIAIG.2013.2260340
Brody, A. L., Mandelkern, M. A., Olmstead, R. E., Jou, J., Tiongson, E., Allen, V., et al. (2007). Neural substrates of resisting craving during cigarette cue exposure. Biol. Psychiatry 62, 642–651. doi: 10.1016/j.biopsych.2006.10.026
Brookings, J. B., Wilson, G. F., and Swain, C. R. (1996). Psychophysiological responses to changes in workload during simulated air traffic control. Biol. Psychol. 42, 361–377. doi: 10.1016/0301-0511(95)05167-8
Chen, C. Y., Huang, M. F., Yen, J. Y., Chen, C. S., Liu, G. C., Yen, C. F., et al. (2014). Brain correlates of response inhibition in Internet gaming disorder. Psychiatry Clin. Neurosci. 69, 201–209. doi: 10.1111/pcn.12224
Chou, Y.-H., Yang, B.-H., Hsu, J.-W., Wang, S.-J., Lin, C.-L., Huang, K.-L., et al. (2013). Effects of video game playing on cerebral blood flow in young adults: a SPECT study. Psychiatry Res. 212, 65–72. doi: 10.1016/j.pscychresns.2012.10.002
Cilia, R., Ko, J. H., Cho, S. S., van Eimeren, T., Marotta, G., Pellecchia, G., et al. (2010). Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling. Neurobiol. Dis. 39, 98–104. doi: 10.1016/j.nbd.2010.03.013
Colom, R., Quiroga, M. Á., Solana, A. B., Burgaleta, M., Román, F. J., Privado, J., et al. (2012). Structural changes after videogame practice related to a brain network associated with intelligence. Intelligence 40, 479–489. doi: 10.1016/j.intell.2012.05.004
Corradi-Dell'Acqua, C., Ueno, K., Ogawa, A., Cheng, K., Rumiati, R. I., and Iriki, A. (2008). Effects of shifting perspective of the self: an fMRI study. Neuroimage 40, 1902–1911. doi: 10.1016/j.neuroimage.2007.12.062
Ding, W., Sun, J., Sun, Y., Zhou, Y., Li, L., Xu, J., et al. (2013). Altered default network resting-state functional connectivity in adolescents with Internet gaming addiction. PLoS ONE 8:e59902. doi: 10.1371/journal.pone.0059902
Dong, G., and Potenza, M. N. (2016). Risk-taking and risky decision-making in Internet gaming disorder: implications regarding online gaming in the setting of negative consequences. J. Psychiatr. Res. 73, 1–8. doi: 10.1016/j.jpsychires.2015.11.011
Engelhardt, C. R., Bartholow, B. D., Kerr, G. T., and Bushman, B. J. (2011). This is your brain on violent video games: neural desensitization to violence predicts increased aggression following violent video game exposure. J. Exp. Soc. Psychol. 47, 1033–1036. doi: 10.1016/j.jesp.2011.03.027
Erickson, K. I., Boot, W. R., Basak, C., Neider, M. B., Prakash, R. S., Voss, M. W., et al. (2010). Striatal volume predicts level of video game skill acquisition. Cereb. Cortex 20, 2522–2530. doi: 10.1093/cercor/bhp293
Feng, Q., Chen, X., Sun, J., Zhou, Y., Sun, Y., Ding, W., et al. (2013). Voxel-level comparison of arterial spin-labeled perfusion magnetic resonance imaging in adolescents with internet gaming addiction. Behav. Brain Funct. 9:33. doi: 10.1186/1744-9081-9-33
Gobel, E. W., Parrish, T. B., and Reber, P. J. (2011). Neural correlates of skill acquisition: decreased cortical activity during a serial interception sequence learning task. Neuroimage 58, 1150–1157. doi: 10.1016/j.neuroimage.2011.06.090
Gong, D., He, H., Liu, D., Ma, W., Dong, L., Luo, C., et al. (2015). Enhanced functional connectivity and increased gray matter volume of insula related to action video game playing. Sci. Rep. 5:9763. doi: 10.1038/srep09763
Gong, D., He, H., Ma, W., Liu, D., Huang, M., Dong, L., et al. (2016). Functional integration between salience and central executive networks: a role for action video game experience. Neural Plast. 2016:9803165. doi: 10.1155/2016/9803165
Granek, J. A., Gorbet, D. J., and Sergio, L. E. (2010). Extensive video-game experience alters cortical networks for complex visuomotor transformations. Cortex 46, 1165–1177. doi: 10.1016/j.cortex.2009.10.009
Green, C. S., and Bavelier, D. (2004). “The cognitive neuroscience of video games,” in Digital Media: Transformation in Human Communication, eds P. Messaris and L. Humphreys (New York, NY: Peter Lang), 211–224.
Green, C. S., and Bavelier, D. (2006). Effect of action video games on the spatial distribution of visuospatial attention. J. Exp. Psychol. Hum. Percept. Perform. 32, 1465–1478. doi: 10.1037/0096-15184.108.40.2065
Haber, S. N. (2011). “Neuroanatomy of reward: a view from the ventral striatum,” in Neurobiology of Sensation and Reward, ed J. Gottfried (Boca Raton, FL: CRC Press/Taylor & Francis), 235–261. doi: 10.1201/b10776-15
Hahn, T., Notebaert, K. H., Dresler, T., Kowarsch, L., Reif, A., and Fallgatter, A. J. (2014). Linking online gaming and addictive behavior: converging evidence for a general reward deficiency in frequent online gamers. Front. Behav. Neurosci. 8:385. doi: 10.3389/fnbeh.2014.00385
Han, D. H., Bolo, N., Daniels, M. A., Arenella, L., Lyoo, I. K., and Renshaw, P. F. (2012a). Brain activity and desire for Internet video game play. Compr. Psychiatry 52, 88–95. doi: 10.1016/j.comppsych.2010.04.004
Han, D. H., Hwang, J. W., and Renshaw, P. F. (2010a). Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction. Exp. Clin. Psychopharmacol. 18, 297–304. doi: 10.1037/a0020023
Han, D. H., Kim, S. M., Bae, S., Renshaw, P. F., and Anderson, J. S. (2015). Brain connectivity and psychiatric comorbidity in adolescents with Internet gaming disorder. Addict. Biol. 22, 802–812. doi: 10.1111/adb.12347
Han, D. H., Kim, S. M., Bae, S., Renshaw, P. F., and Anderson, J. S. (2016). A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play. J. Affect. Disord. 194, 57–64. doi: 10.1016/j.jad.2016.01.013
Han, D. H., Kim, Y. S., Lee, Y. S., Min, K. J., and Renshaw, P. F. (2010b). Changes in cue-induced, prefrontal cortex activity with video-game play. Cyberpsychol. Behav. Soc. Netw. 13, 655–661. doi: 10.1089/cyber.2009.0327
Han, D. H., Lyoo, I. K., and Renshaw, P. F. (2012b). Differential regional gray matter volumes in patients with on-line game addiction and professional gamers. J. Psychiatr. Res. 46, 507–515. doi: 10.1016/j.jpsychires.2012.01.004
Hartanto, A., Toh, W. X., and Yang, H. (2016). Age matters: the effect of onset age of video game play on task-switching abilities. Attent. Percept. Psychophys. 78, 1125–1136. doi: 10.3758/s13414-016-1068-9
Havranek, M., Langer, N., Cheetham, M., and Jäncke, L. (2012). Perspective and agency during video gaming influences spatial presence experience and brain activation patterns. Behav. Brain Funct. 8:34. doi: 10.1186/1744-9081-8-34
Heinz, A., Beck, A., Grüsser, S. M., Grace, A. A., and Wrase, J. (2009). Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict. Biol. 14, 108–118. doi: 10.1111/j.1369-1600.2008.00136.x
Hong, S.-B., Harrison, B. J., Dandash, O., Choi, E.-J., Kim, S.-C., Kim, H.-H., et al. (2015). A selective involvement of putamen functional connectivity in youth with internet gaming disorder. Brain Res. 1602, 85–95. doi: 10.1016/j.brainres.2014.12.042
Hou, H., Jia, S., Hu, S., Fan, R., Sun, W., Sun, T., et al. (2012). Reduced striatal dopamine transporters in people with internet addiction disorder. J. Biomed. Biotechnol. 2012:854524. doi: 10.1155/2012/854524
Hsu, W.-Y., Zanto, T. P., Anguera, J. A., Lin, Y.-Y., and Gazzaley, A. (2015). Delayed enhancement of multitasking performance: effects of anodal transcranial direct current stimulation on the prefrontal cortex. Cortex 69, 175–185. doi: 10.1016/j.cortex.2015.05.014
Hubert-Wallander, B., Green, C. S., Sugarman, M., and Bavelier, D. (2011). Changes in search rate but not in the dynamics of exogenous attention in action videogame players. Atten. Percept. Psychophys. 73, 2399–2412. doi: 10.3758/s13414-011-0194-7
Hummer, T. A., Wang, Y., Kronenberger, W. G., Mosier, K. M., Kalnin, A. J., Dunn, D. W., et al. (2010). Short-term violent video game play by adolescents alters prefrontal activity during cognitive inhibition. Media Psychol. 13, 136–154. doi: 10.1080/15213261003799854
Hunicke, R. (2005). “The case for dynamic difficulty adjustment in games,” in Proceedings of the 2005 ACM SIGCHI International Conference on Advances in Computer Entertainment Technology—ACE'05 (New York, NY: ACM Press), 429–433.
Hyun, G. J., Shin, Y. W., Kim, B.-N. N., Cheong, J. H., Jin, S. N., and Han, D. H. (2013). Increased cortical thickness in professional on-line gamers. Psychiatry Investig. 10, 388–392. doi: 10.4306/pi.2013.10.4.388
Ivarsson, M., Anderson, M., Åkerstedt, T., and Lindblad, F. (2013). The effect of violent and nonviolent video games on heart rate variability, sleep, and emotions in adolescents with different violent gaming habits. Psychosom. Med. 75, 390–396. doi: 10.1097/PSY.0b013e3182906a4c
Izzetoglu, K., Bunce, S., Onaral, B., Pourrezaei, K., and Chance, B. (2004). Functional optical brain imaging using near-infrared during cognitive tasks. Int. J. Hum. Comput. Interact. 17, 211–227. doi: 10.1207/s15327590ijhc1702_6
Jin, C., Zhang, T., Cai, C., Bi, Y., Li, Y., Yu, D., et al. (2016). Abnormal prefrontal cortex resting state functional connectivity and severity of internet gaming disorder. Brain Imaging Behav. 10, 719–729. doi: 10.1007/s11682-015-9439-8
Kätsyri, J., Hari, R., Ravaja, N., and Nummenmaa, L. (2013a). Just watching the game ain't enough: striatal fMRI reward responses to successes and failures in a video game during active and vicarious playing. Front. Hum. Neurosci. 7:278. doi: 10.3389/fnhum.2013.00278
Kätsyri, J., Hari, R., Ravaja, N., and Nummenmaa, L. (2013b). The opponent matters: elevated FMRI reward responses to winning against a human versus a computer opponent during interactive video game playing. Cereb. Cortex 23, 2829–2839. doi: 10.1093/cercor/bhs259
Khairuddin, H. R., Malik, A. S., Mumtaz, W., Kamel, N., and Xia, L. (2013). Analysis of EEG signals regularity in adults during video game play in 2D and 3D. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2013, 2064–2067. doi: 10.1109/EMBC.2013.6609938
Kim, H., Kim, Y. K., Gwak, A. R., Lim, J.-A. A., Lee, J.-Y. Y., Jung, H. Y., et al. (2015). Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: a comparison with patients with alcohol use disorder and healthy controls. Prog. Neuro Psychopharmacol. Biol. Psychiatry 60, 104–111. doi: 10.1016/j.pnpbp.2015.02.004
Kim, P. W., Kim, S. Y., Shim, M., Im, C.-H. H., and Shon, Y.-M. M. (2013). The influence of an educational course on language expression and treatment of gaming addiction for massive multiplayer online role-playing game (MMORPG) players. Comput. Educ. 63, 208–217. doi: 10.1016/j.compedu.2012.12.008
Kim, S. H., Baik, S.-H., Park, C. S., Kim, S. J., Choi, S. W., and Kim, S. E. (2011). Reduced striatal dopamine D2 receptors in people with Internet addiction. Neuroreport 22, 407–411. doi: 10.1097/WNR.0b013e328346e16e
Kim, Y.-H., Kang, D.-W., Kim, D., Kim, H.-J., Sasaki, Y., and Watanabe, T. (2015). Real-time strategy video game experience and visual perceptual learning. J. Neurosci. 35, 10485–10492. doi: 10.1523/JNEUROSCI.3340-14.2015
Klasen, M., Weber, R., Kircher, T. T. J., Mathiak, K. A., and Mathiak, K. (2012). Neural contributions to flow experience during video game playing. Soc. Cogn. Affect. Neurosci. 7, 485–495. doi: 10.1093/scan/nsr021
Ko, C. H., Liu, G. C., Hsiao, S., Yen, J. Y., Yang, M. J., Lin, W. C., et al. (2009). Brain activities associated with gaming urge of online gaming addiction. J. Psychiatr. Res. 43, 739–747. doi: 10.1016/j.jpsychires.2008.09.012
Ko, C. H., Liu, G. C., Yen, J. Y., Chen, C. Y., Yen, C. F., and Chen, C. S. (2013). Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects. Addict. Biol. 18, 559–569. doi: 10.1111/j.1369-1600.2011.00405.x
Ko, C.-H., Yen, J.-Y., Chen, C.-C., Chen, S.-H., and Yen, C.-F. (2005). Gender differences and related factors affecting online gaming addiction among Taiwanese adolescents. J. Nerv. Ment. Dis. 193, 273–277. doi: 10.1097/01.nmd.0000158373.85150.57
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., et al. (1998). Evidence for striatal dopamine release during a video game. Nature 393, 266–268. doi: 10.1038/30498
Kringelbach, M. L., and Rolls, E. T. (2004). The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog. Neurobiol. 72, 341–372. doi: 10.1016/j.pneurobio.2004.03.006
Krishnan, L., Kang, A., Sperling, G., and Srinivasan, R. (2013). Neural strategies for selective attention distinguish fast-action video game players. Brain Topogr. 26, 83–97. doi: 10.1007/s10548-012-0232-3
Kühn, S., Gleich, T., Lorenz, R. C., Lindenberger, U., and Gallinat, J. (2013). Playing Super Mario induces structural brain plasticity: gray matter changes resulting from training with a commercial video game. Mol. Psychiatry 19, 265–271. doi: 10.1038/mp.2013.120
Kühn, S., Lorenz, R. C., Banaschewski, T., Barker, G. J., Büchel, C., Conrod, P. J., et al. (2014). Positive association of video game playing with left frontal cortical thickness in adolescents. PLoS ONE 9:e91506. doi: 10.1371/journal.pone.0091506
Lampit, A., Hallock, H., and Valenzuela, M. (2014). Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Med. 11:e1001756. doi: 10.1371/journal.pmed.1001756
Latham, A. J., Patston, L. L. M., Westermann, C., Kirk, I. J., and Tippett, L. J. (2013). Earlier visual N1 latencies in expert video-game players: a temporal basis of enhanced visuospatial performance? PLoS ONE 8:e75231. doi: 10.1371/journal.pone.0075231
Lee, H., Voss, M. W., Prakash, R. S., Boot, W. R., Vo, L. T. K., Basak, C., et al. (2012). Videogame training strategy-induced change in brain function during a complex visuomotor task. Behav. Brain Res. 232, 348–357. doi: 10.1016/j.bbr.2012.03.043
Lee, J., Lee, S., Chun, J. W., Cho, H., Kim, D., and Jung, Y.-C. (2015). Compromised prefrontal cognitive control over emotional interference in adolescents with internet gaming disorder. Cyberpsychol. Behav. Soc. Netw. 18, 661–668. doi: 10.1089/cyber.2015.0231
Lianekhammy, J., and Werner-Wilson, R. (2015). Links to prosocial factors and alpha asymmetry in adolescents during violent and non-violent video game play. Child Stud. Asia Pac. Context 5, 63–81. doi: 10.5723/csac.2015.5.2.063
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., et al. (2009). The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: explanation and Elaboration. PLoS Med. 6:e1000100. doi: 10.1371/journal.pmed.1000100
Liu, J., Gao, X.-P. P., Osunde, I., Li, X., Zhou, S.-K. K., Zheng, H.-R., et al. (2010). Increased regional homogeneity in internet addiction disorder: a resting state functional magnetic resonance imaging study. Chin. Med. J. 123, 1904–1908. doi: 10.3760/cma.j.issn.0366-6999.2010.14.014
Liu, J., Li, W., Zhou, S., Zhang, L., Wang, Z., Zhang, Y., et al. (2015). Functional characteristics of the brain in college students with internet gaming disorder. Brain Imaging Behav. 10, 60–67. doi: 10.1007/s11682-015-9364-x
Liu, T., Saito, H., and Oi, M. (2012). Distinctive activation patterns under intrinsically versus extrinsically driven cognitive loads in prefrontal cortex: a near-infrared spectroscopy study using a driving video game. Neurosci. Lett. 506, 220–224. doi: 10.1016/j.neulet.2011.11.009
Liu, T., Saito, H., and Oi, M. (2015). Online monitoring of the social presence effects in a two-person-like driving video game using near-infrared spectroscopy. Jpn. Psychol. Res. 57, 242–253. doi: 10.1111/jpr.12080
Liu, Y., Teng, Z., Lan, H., Zhang, X., and Yao, D. (2015). Short-term effects of prosocial video games on aggression: an event-related potential study. Front. Behav. Neurosci. 9:193. doi: 10.3389/fnbeh.2015.00193
Lohse, K., Shirzad, N., Verster, A., Hodges, N., and Van der Loos, H. F. M. (2013). Video games and rehabilitation: using design principles to enhance engagement in physical therapy. J. Neurol. Phys. Ther. 37, 166–175. doi: 10.1097/NPT.0000000000000017
Luijten, M., Meerkerk, G.-J., Franken, I. H. A., van de Wetering, B. J. M., and Schoenmakers, T. M. (2015). An fMRI study of cognitive control in problem gamers. Psychiatry Res. Neuroimaging 231, 262–268. doi: 10.1016/j.pscychresns.2015.01.004
Maclin, E. L., Mathewson, K. E., Low, K. A., Boot, W. R., Kramer, A. F., Fabiani, M., et al. (2011). Learning to multitask: effects of video game practice on electrophysiological indices of attention and resource allocation. Psychophysiology 48, 1173–1183. doi: 10.1111/j.1469-8986.2011.01189.x
Martínez, K., Solana, A. B., Burgaleta, M., Hernández-Tamames, J. A., Alvarez-Linera, J., Román, F. J., et al. (2013). Changes in resting-state functionally connected parietofrontal networks after videogame practice. Hum. Brain Mapp. 34, 3143–3157. doi: 10.1002/hbm.22129
Mathewson, K. E., Basak, C., Maclin, E. L., Low, K. A., Boot, W. R., Kramer, A. F., et al. (2012). Different slopes for different folks: alpha and delta EEG power predict subsequent video game learning rate and improvements in cognitive control tasks. Psychophysiology 49, 1558–1570. doi: 10.1111/j.1469-8986.2012.01474.x
Mathiak, K. A., Klasen, M., Weber, R., Ackermann, H., Shergill, S. S., and Mathiak, K. (2011). Reward system and temporal pole contributions to affective evaluation during a first person shooter video game. BMC Neurosci. 12:66. doi: 10.1186/1471-2202-12-66
Mathiak, K. A., Klasen, M., Zvyagintsev, M., Weber, R., and Mathiak, K. (2013). Neural networks underlying affective states in a multimodal virtual environment: contributions to boredom. Front. Hum. Neurosci. 7:820. doi: 10.3389/fnhum.2013.00820
Matsuda, G., and Hiraki, K. (2004). “Prefrontal cortex deactivation during video game play,” in Gaming, Simulations, and Society, eds R. Shiratori, K. Arai, and F. Kato (Tokyo: Springer-Verlag), 101–109. doi: 10.1007/4-431-26797-2_11
Matsuda, G., and Hiraki, K. (2006). Sustained decrease in oxygenated hemoglobin during video games in the dorsal prefrontal cortex: a NIRS study of children. Neuroimage 29, 706–711. doi: 10.1016/j.neuroimage.2005.08.019
McGarry, W., Strenziok, M., Cisler, D. S., Clarke, E., Santa Cruz, S. A., Thompson, J. C., et al. (2013). “Real-time strategy video game training increases fronto-parietal cortical thickness, default mode network connectivity, and reasoning ability in healthy older adults,” in 20th Annual Meeting of the Cognitive-Neuroscience-Society (San Francisco, CA), 132–132.
Mishra, J., Zinni, M., Bavelier, D., and Hillyard, S. A. (2011). Neural basis of superior performance of action videogame players in an attention-demanding task. J. Neurosci. 31, 992–998. doi: 10.1523/JNEUROSCI.4834-10.2011
Montag, C., Weber, B., Trautner, P., Newport, B., Markett, S., Walter, N. T., et al. (2012). Does excessive play of violent first-person-shooter-video-games dampen brain activity in response to emotional stimuli? Biol. Psychol. 89, 107–111. doi: 10.1016/j.biopsycho.2011.09.014
Nagamitsu, S., Nagano, M., Yamashita, Y., Takashima, S., and Matsuishi, T. (2006). Prefrontal cerebral blood volume patterns while playing video games-A near-infrared spectroscopy study. Brain Dev. 28, 315–321. doi: 10.1016/j.braindev.2005.11.008
Nikolaidis, A., Voss, M. W., Lee, H., Vo, L. T. K., and Kramer, A. F. (2014). Parietal plasticity after training with a complex video game is associated with individual differences in improvements in an untrained working memory task. Front. Hum. Neurosci. 8:169. doi: 10.3389/fnhum.2014.00169
Obeso, I., Robles, N., Marrón, E. M., and Redolar-Ripoll, D. (2013). Dissociating the role of the pre-SMA in response Inhibition and switching: a combined online and offline TMS approach. Front. Hum. Neurosci. 7:150. doi: 10.3389/fnhum.2013.00150
Park, H. S., Kim, S. H., Bang, S. A., Yoon, E. J., Cho, S. S., and Kim, S. E. (2010). Altered regional cerebral glucose metabolism in internet game overusers: a 18F-fluorodeoxyglucose positron emission tomography study. CNS Spectr. 15, 159–166. doi: 10.1017/S1092852900027437
Park, S. Y., Kim, S. M., Roh, S., Soh, M.-A., Lee, S. H., Kim, H., et al. (2016). The effects of a virtual reality treatment program for online gaming addiction. Comput. Methods Programs Biomed. 129, 99–108. doi: 10.1016/j.cmpb.2016.01.015
Pellouchoud, E., Smith, M. E., McEvoy, L. K., and Gevins, A. (1999). Mental effort-related EEG modulation during video-game play: comparison between juvenile subjects with epilepsy and normal control subjects. Epilepsia 40 (Suppl. 4), 38–43. doi: 10.1111/j.1528-1157.1999.tb00905.x
Petras, K., Ten Oever, S., and Jansma, B. M. (2015). The effect of distance on moral engagement: event related potentials and alpha power are sensitive to perspective in a virtual shooting task. Front. Psychol. 6:2008. doi: 10.3389/fpsyg.2015.02008
Petry, N. M., Rehbein, F., Gentile, D. A., Lemmens, J. S., Rumpf, H.-J., Mößle, T., et al. (2014). An international consensus for assessing internet gaming disorder using the new DSM-5 approach. Addiction 109, 1399–1406. doi: 10.1111/add.12457
Powers, K. L., Brooks, P. J., Aldrich, N. J., Palladino, M. A., and Alfieri, L. (2013). Effects of video-game play on information processing: a meta-analytic investigation. Psychon. Bull. Rev. 20, 1055–1079. doi: 10.3758/s13423-013-0418-z
Prakash, R. S., De Leon, A. A., Mourany, L., Lee, H., Voss, M. W., Boot, W. R., et al. (2012). Examining neural correlates of skill acquisition in a complex videogame training program. Front. Hum. Neurosci. 6:115. doi: 10.3389/fnhum.2012.00115
Regenbogen, C., Herrmann, M., and Fehr, T. (2010). The neural processing of voluntary completed, real and virtual violent and nonviolent computer game scenarios displaying predefined actions in gamers and nongamers. Soc. Neurosci. 5, 221–240. doi: 10.1080/17470910903315989
Russoniello, C. V., O'brien, K., and Parks, J. M. (2009). EEG, HRV and psychological correlates while playing Bejeweled II: a randomized controlled study. Annu. Rev. CyberTherapy Telemed. 7, 189–192. doi: 10.3233/978-1-60750-017-9-189
Sánchez-González, M. A., García-Cabezas, M. A., Rico, B., and Cavada, C. (2005). The primate thalamus is a key target for brain dopamine. J. Neurosci. 25, 6076–6083. doi: 10.1523/JNEUROSCI.0968-05.2005
Sheikholeslami, C., Yuan, H., He, E. J., Bai, X., Yang, L., and He, B. (2007). A high resolution EEG study of dynamic brain activity during video game play. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2007, 2489–2491. doi: 10.1109/IEMBS.2007.4352833
Song, W. H., Han, D. H., and Shim, H. J. (2013). Comparison of brain activation in response to two dimensional and three dimensional on-line games. Psychiatry Investig. 10, 115–120. doi: 10.4306/pi.2013.10.2.115
Strenziok, M., Clarke, E., Santa Cruz, S. A., Thompson, J. C., Parasuraman, R., and Greenwood, P. M. (2013). “Effects of real-time strategy video game training on white matter integrity in interhemispheric posterior callosal connections of the precuneus in healthy aging,” in 20th Annu. Meet. Cogn. (San Francisco, CA), 190.
Strenziok, M., Krueger, F., Deshpande, G., Lenroot, R. K., Van der meer, E., and Grafman, J. (2011). Fronto-parietal regulation of media violence exposure in adolescents: a multi-method study. Soc. Cogn. Affect. Neurosci. 6, 537–547. doi: 10.1093/scan/nsq079
Strenziok, M., Parasuraman, R., Clarke, E., Cisler, D. S., Thompson, J. C., and Greenwood, P. M. (2014). Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity. Neuroimage 85(Pt 3), 1027–1039. doi: 10.1016/j.neuroimage.2013.07.069
Subhani, A. R., Likun, X., and Saeed Malik, A. (2012). Association of autonomic nervous system and EEG scalp potential during playing 2D grand turismo 5. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 3420–3423. doi: 10.1109/EMBC.2012.6346700
Tsai, M.-H., Cherng, R.-J., and Chen, J.-Y. (2013). “Visuospatial attention abilities in the action and real time strategy video game players as compared with nonplayers,” in 2013 1st International Conference on Orange Technologies (ICOT) (Tainan: IEEE), 264–265.
Tachtsidis, I., and Papaioannou, A. (2013). Investigation of frontal lobe activation with fNIRS and systemic changes during video gaming. Adv. Exp. Med. Biol. 789, 89–95. doi: 10.1007/978-1-4614-7411-1_13
Takeuchi, H., Taki, Y., Hashizume, H., Asano, K., Asano, M., Sassa, Y., et al. (2016). Impact of videogame play on the brain's microstructural properties: cross-sectional and longitudinal analyses. Mol. Psychiatry 21, 1781–1789. doi: 10.1038/mp.2015.193
Tanaka, S., Ikeda, H., Kasahara, K., Kato, R., Tsubomi, H., Sugawara, S. K., et al. (2013). Larger right posterior parietal volume in action video game experts: a behavioral and voxel-based morphometry (VBM) study. PLoS ONE 8:e66998. doi: 10.1371/journal.pone.0066998
Tian, M., Chen, Q., Zhang, Y., Du, F., Hou, H., Chao, F., et al. (2014). PET imaging reveals brain functional changes in internet gaming disorder. Eur. J. Nucl. Med. Mol. Imaging 41, 1388–1397. doi: 10.1007/s00259-014-2708-8
Turel, O., Romashkin, A., and Morrison, K. M. (2016). Health outcomes of information system use lifestyles among adolescents: videogame addiction, sleep curtailment and cardio-metabolic deficiencies. PLoS ONE 11:e0154764. doi: 10.1371/journal.pone.0154764
Vo, L. T. K., Walther, D. B., Kramer, A. F., Erickson, K. I., Boot, W. R., Voss, M. W., et al. (2011). Predicting individuals' learning success from patterns of pre-learning MRI activity. PLoS ONE 6:e16093. doi: 10.1371/journal.pone.0016093
Vogan, V. M. M., Morgan, B. R. R., Powell, T. L. L., Smith, M. L. L., and Taylor, M. J. J. (2016). The neurodevelopmental differences of increasing verbal working memory demand in children and adults. Dev. Cogn. Neurosci. 17, 19–27. doi: 10.1016/j.dcn.2015.10.008
Volkow, N. D., Wang, G.-J., Fowler, J. S., Tomasi, D., Telang, F., and Baler, R. (2010). Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit. Bioessays 32, 748–755. doi: 10.1002/bies.201000042
Voss, M. W., Prakash, R. S., Erickson, K. I., Boot, W. R., Basak, C., Neider, M. B., et al. (2012). Effects of training strategies implemented in a complex videogame on functional connectivity of attentional networks. Neuroimage 59, 138–148. doi: 10.1016/j.neuroimage.2011.03.052
Wang, P., Liu, H.-H., Zhu, X.-T., Meng, T., Li, H.-J., and Zuo, X.-N. (2016). Action video game training for healthy adults: a meta-analytic study. Front. Psychol. 7:907. doi: 10.3389/fpsyg.2016.00907
Wang, Y., Mathews, V. P., Kalnin, A. J., Mosier, K. M., Dunn, D. W., Saykin, A. J., et al. (2009). Short term exposure to a violent video game induces changes in frontolimbic circuitry in adolescents. Brain Imaging Behav. 3, 38–50. doi: 10.1007/s11682-008-9058-8
Wang, Y., Yin, Y., Sun, Y., Zhou, Y., Chen, X., Ding, W., et al. (2015). Decreased prefrontal lobe interhemispheric functional connectivity in adolescents with internet gaming disorder: a primary study using resting-state fMRI. PLoS ONE 10:e0118733. doi: 10.1371/journal.pone.0118733
Weber, R., Ritterfeld, U., and Mathiak, K. (2006). Does playing violent video games induce aggression? Empirical evidence of a functional magnetic resonance imaging study. Media Psychol. 8, 39–60. doi: 10.1207/S1532785XMEP0801_4
Weber, R., Tamborini, R., Westcott-Baker, A., and Kantor, B. (2009). Theorizing flow and media enjoyment as cognitive synchronization of attentional and reward networks. Commun. Theor. 19, 397–422. doi: 10.1111/j.1468-2885.2009.01352.x
Wee, C.-Y., Zhao, Z., Yap, P.-T., Wu, G., Shi, F., Price, T., et al. (2014). Disrupted brain functional network in internet addiction disorder: a resting-state functional magnetic resonance imaging study. PLoS ONE 9:e107306. doi: 10.1371/journal.pone.0107306
West, G. L., Drisdelle, B. L., Konishi, K., Jackson, J., Jolicoeur, P., and Bohbot, V. D. (2015). Habitual action video game playing is associated with caudate nucleus- dependent navigational strategies. Proc. R. Soc. London B Biol. Sci. 282:20142952. doi: 10.1098/rspb.2014.2952
Wu, S., Cheng, C. K., Feng, J., D'Angelo, L., Alain, C., and Spence, I. (2012). Playing a first-person shooter video game induces neuroplastic change. J. Cogn. Neurosci. 24, 1286–1293. doi: 10.1162/jocn_a_00192
Xing, L., Yuan, K., Bi, Y., Yin, J., Cai, C., Feng, D., et al. (2014). Reduced fiber integrity and cognitive control in adolescents with internet gaming disorder. Brain Res. 1586, 109–117. doi: 10.1016/j.brainres.2014.08.044
Yoshida, K., Sawamura, D., Inagaki, Y., Ogawa, K., Ikoma, K., and Sakai, S. (2014). Brain activity during the flow experience: a functional near-infrared spectroscopy study. Neurosci. Lett. 573, 30–34. doi: 10.1016/j.neulet.2014.05.011
Yuan, K., Cheng, P., Dong, T., Bi, Y., Xing, L., Yu, D., et al. (2013a). Cortical thickness abnormalities in late adolescence with online gaming addiction. PLoS ONE 8:e53055. doi: 10.1371/journal.pone.0053055
Yuan, K., Jin, C., Cheng, P., Yang, X., Dong, T., Bi, Y., et al. (2013b). Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction. PLoS ONE 8:e78708. doi: 10.1371/journal.pone.0078708
Zhang, J.-T., Yao, Y.-W., Li, C.-S. R., Zang, Y.-F., Shen, Z.-J., Liu, L., et al. (2016). Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder. Addict. Biol. 21, 743–751. doi: 10.1111/adb.12247
Zhang, Y., Du, G., Yang, Y., Qin, W., Li, X., and Zhang, Q. (2015). Higher integrity of the motor and visual pathways in long-term video game players. Front. Hum. Neurosci. 9:98. doi: 10.3389/fnhum.2015.00098
Zvyagintsev, M., Klasen, M., Weber, R., Sarkheil, P., Esposito, F., Mathiak, K. A., et al. (2016). Violence-related content in video game may lead to functional connectivity changes in brain networks as revealed by fMRI-ICA in young men. Neuroscience 320, 247–258. doi: 10.1016/j.neuroscience.2016.01.056
Keywords: addiction, cognitive improvement, functional changes, internet gaming disorder, neural correlates, neuroimaging, structural changes, video games
Citation: Palaus M, Marron EM, Viejo-Sobera R and Redolar-Ripoll D (2017) Neural Basis of Video Gaming: A Systematic Review. Front. Hum. Neurosci. 11:248. doi: 10.3389/fnhum.2017.00248
Received: 16 September 2016; Accepted: 26 April 2017;
Published: 22 May 2017.
Edited by:Soledad Ballesteros, Universidad Nacional de Educación a Distancia, Spain
Reviewed by:Tao Liu, Zhejiang University, China
Pierre Mégevand, Université de Genève, Switzerland
José Manuel Reales, Universidad Nacional de Educación a Distancia, Spain
Copyright © 2017 Palaus, Marron, Viejo-Sobera and Redolar-Ripoll. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Marc Palaus, firstname.lastname@example.org