Mini Review ARTICLE
Alzheimer’s Disease And Cancer: When Two Monsters Cannot be Together
- 1College of Medicine and Public Health, Flinders University, Australia
- 2Psychosomatics Tagesklinic, Germany
Alzheimer’s disease (AD) and cancer are among the leading causes of human death around the world. While neurodegeneration is the main feature of AD, the most important characteristic of malignant tumours is cell proliferation, placing these two diseases in opposite sides of cell division spectrum. Interestingly, AD and cancer’s pathologies consist of a remarkable common feature and that is the presence of active cell cycle in both conditions. In an in vitro model of primary adult neuronal culture, we previously showed that treating cell with beta amyloid forced neurons to start a cell cycle. Instead of cell division, however neuronal cell cycle was aborted and a massive neurodegeneration was left behind as the consequence. A high level of cell cycle entry, which is a requirement for cancer pathogenesis, was reported in clinically diagnosed cases of AD, leading to neurodegeneration. The diverse clinical manifestation of a similar etiology, have puzzled researchers for many years. In fact, the evidence showed an inverse association between AD and cancer prevalence, suggesting that switching pathogenesis toward AD protects patients against cancer and vice versa. In this minireview, we discussed the possibility of involvement of cell proliferation and survival dysregulation as the underlying mechanism of neurodegeneration in AD, and the leading event to develop both disorders’ pathology. As examples, the role of phosphoinositide 3 kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway in cell cycle re-entry and blocking autophagy are discussed as potential common intracellular components between AD and cancer pathogenesis, with diverse clinical diagnosis.
Keywords: Alzheimer's disease, Cell Cycle, Cancer, beta amyloid, PI3K/Akt/mTOR signalling pathway, neurodegeneration, Autophagy, Tau phosphorylation
Received: 29 Jun 2018;
Accepted: 11 Feb 2019.
Edited by:Efthimios M. Skoulakis, Alexander Fleming Biomedical Sciences Research Center, Greece
Reviewed by:Ioannis Sotiropoulos, University of Minho, Portugal
Xiao-Xin Yan, Central South University, China
Copyright: © 2019 Majd, Power and Majd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Shohreh Majd, Flinders University, College of Medicine and Public Health, Adelaide, 5042, South Australia, Australia, email@example.com