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REVIEW article
Front. Neurosci.
Sec. Autonomic Neuroscience
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1362899
The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions
Provisionally accepted- 1 Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China
- 2 Gansu Provincial Second People's Hospital, Lanzhou, Gansu Province, China
- 3 Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China
Central 5-hydroxytryptaminergic dorsal raphe nucleus (5-HTDRN)-bed nucleus of stria terminalis (BNST) neural circuit dysfunction is one of the important neurobiological basis of anxiety and fear disorders. Under stress, 5-hydroxytryptamine (5-HT) neurons act on BNST receptors to attenuate anxiety and fear responses or enhance anxiety and fear. In BNST, corticotropin releasing factor neurons play a role in regulating emotions by reversely regulating excitatory or inhibitory 5-HT neurons. The composition of 5-HTDRN-BNST neural circuit, the pathological changes of 5-HTDRN-BNST neural circuit function damage under stress, and the effects of 5-HTDRN-BNST neural circuit on anxiety disorder, panic disorder and post-traumatic stress disorder were analyzed and are summarized in this paper. The characteristics of functional changes of the neural circuit and its effects on brain functional activities provide a basis and ideas for the treatment of anxiety and fear disorders through the regulation of 5-HTDRN-BNST neural circuit, and they also provide a new perspective for understanding the pathological mechanism of such diseases.When the body is transiently or continuously exposed to trauma and acute stress, people will experience a variety of negative emotions such as fear, anxiety, and depression. Most of these risk factors are classified as exposure to traumatic events. These emotions are mainly due to the central
Keywords: 5-HTDRN-BNST neural circuit, Anxiety, Fear, mechanism progress, stress, dysfunction
Received: 29 Dec 2023; Accepted: 10 Apr 2024.
Copyright: © 2024 ZHENG, Li, YAN, YAO and WANG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xingke YAN, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China
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