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Front. Mol. Neurosci. | doi: 10.3389/fnmol.2019.00129

Elevated serum SIRT 2 may differentiate Parkinson's Disease from Atypical Parkinsonian Syndromes

Amrendra P. Singh1, Ramana G1, Teena Bajaj1, Vishwajeet Singh1, Sadanand Dwivedi1, Madhuri Behari1, A B. Dey1 and  Sharmistha Dey1*
  • 1All India Institute of Medical Sciences, India

Atypical Parkinson Syndromes (APSs) often have symptoms that overlap with those of Parkinson's disease (PD), especially in early in disease, making these disorders difficult to diagnose. Previous studies have demonstrated association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with Sirtuin (SIRT)2 proteins for modulating PD. We aimed to evaluate SIRT proteins expression in serum of PD patients and compare it with APSs and normal elderly control (GC); and correlate with α-Syn. SIRT proteins expression was evaluated in sera of 68 PD; 34 APS and 68 GC without any neuro-psychiatric illness as controls by Surface Plasmon Resonance. SIRT2 expression was correlated with α-Syn in PD and GC. Significant (p<0.0001) differences were observed between serum SIRT2 concentration in PD and APS and GC; and between APS and GC. ROC analysis revealed the strong cut off value to differentiate PD from APS and GC and also APS from GC. Significant correlation was observed among SIRT2 levels in early PD patients with UPDRS, H and Y and increase duration of disease. In addition, a strong positive correlation of SIRT2 with α-Syn (p<0.0001) was observed. However, no such difference was detected for serum SIRT1 in cases of PD and APS; and GC. The present study is the first to report elevated serum SIRT2 in PD. The study also provided a simple test to distinguish PD from APS and may have translational utility for diagnosis.

Keywords: Parkinson’s disease, Atypical Parkinsonian syndromes, Protein marker, α-Synuclein, SIRTUIN, SPR

Received: 07 Mar 2019; Accepted: 03 May 2019.

Edited by:

Arianna Bellucci, University of Brescia, Italy

Reviewed by:

Sandra M. Cardoso, University of Coimbra, Portugal
Ian F. Harrison, University College London, United Kingdom  

Copyright: © 2019 Singh, G, Bajaj, Singh, Dwivedi, Behari, Dey and Dey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Sharmistha Dey, All India Institute of Medical Sciences, New Delhi, 110 029, National Capital Territory of Delhi, India, sharmistha_d@hotmail.com