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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.01041

Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study

 Minh T. Duong1, 2*, David Holz1, Sven Dittrich1, Muhannad Alkassar1 and Sigrid Leyendecker1
  • 1University of Erlangen Nuremberg, Germany
  • 2Hanoi University, Vietnam

In this paper, we are investigating the interaction between different passive material models
and the mechano-electrical feedback (MEF) in cardiac modelling. Various types of
passive mechanical laws (nearly incompressible/compressible, polynomial/exponential-type,
transversally isotropic/orthotropic material models) are integrated in a fully coupled electromechanical
model in order to study their specific influence on the overall MEF behaviour.
Our computational model is based on a three-dimensional (3D) geometry of a
healthy rat left ventricle reconstructed from magnetic resonance imaging (MRI). The electromechanically
coupled problem is solved using a fully implicit finite element-based approach.
The effects of different passive material models on the MEF are studied with the
help of numerical examples. It turns out that there is a significant difference between the
behaviour of the MEF for compressible and incompressible material models. Numerical results
for the incompressible models exhibit that a change in the electrophysiology can be
observed such that the transmembrane potential (TP) is unable to reach the resting state in
the repolarisation phase and this leads to non-zero relaxation deformations. The most significant
and strongest effects of the MEF on the rat cardiac muscle response are observed
for the exponential passive material law.

Keywords: Electromechanics, Excitation-contraction, Mechano-electrical feedback, passive mechanics, rat left ventricle, FEM, Compressible, Incompressible, Exponential, Polynomial, Orthotropic, Transversely isotropic

Received: 01 Sep 2018; Accepted: 30 Jul 2019.

Edited by:

Javier Saiz, Polytechnic University of Valencia, Spain

Reviewed by:

Vicky Y. Wang, The University of Auckland, New Zealand
Simone Pezzuto, Università della Svizzera italiana, Switzerland
Jeffrey Omens, University of California, San Diego, United States  

Copyright: © 2019 Duong, Holz, Dittrich, Alkassar and Leyendecker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Minh T. Duong, University of Erlangen Nuremberg, Erlangen, Germany, minh.tuan.duong@fau.de