In the original article, there was an error in Table 1 as published. In this table, the chemical structures of TDI-11861 and TDI-11155 were incorrect as the chloro and amino groups of the pyrimidine were drawn in the incorrect positions. In the correct chemical structures, the chloro and amino groups are located at the 4- and 2-positions, respectively. The corrected Table 1 appears below.
TABLE 1
| sAC inhibitor structure | Standard assay IC50 (nM) | Subnanomolar assay IC50 (nM) | Cellular (4-4) IC50 (nM) | |
|---|---|---|---|---|
| LRE1 |  | 3238 | n/d | 5266 |
| TDI-10229 |  | 159 | 194 | 114 |
| TDI-11155 |  | 11 | 11 | 16 |
| TDI-11861 |  | ≤2.5 | 1.7 | 5 |
| TDI-11893 |  | ≤2.5 | 1.7 | 19 |
| TDI-11891 |  | ≤2.5 | 0.33 | 2.3 |
In Vitro Biochemical and Cellular Potency of sAC Inhibitors.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
soluble adenylyl cyclase, male contraceptive, residence time, drug development, picomolar potency, binding kinetics, lead optimization, SPR
Citation
Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR and Buck J (2023) Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Front. Physiol. 14:1163389. doi: 10.3389/fphys.2023.1163389
Received
10 February 2023
Accepted
21 February 2023
Published
06 March 2023
Volume
14 - 2023
Edited and reviewed by
Muhammad Aslam, University of Giessen, Germany
Updates
Copyright
© 2023 Rossetti, Ferreira, Ghanem, Buck, Steegborn, Myers, Meinke, Levin and Buck.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lonny R. Levin, llevin@med.cornell.edu
This article was submitted to Cell Physiology, a section of the journal Frontiers in Physiology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.