SYSTEMATIC REVIEW article
Front. Aging Neurosci.
Sec. Parkinson’s Disease and Aging-related Movement Disorders
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1440850
This article is part of the Research TopicCognition in Parkinson's diseaseView all 5 articles
Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson's disease: A systematic review and meta-analysis
Provisionally accepted
- 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, China., Shanghai, China
- 2Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
- 3Shanghai University of Medicine and Health Sciences, Shanghai, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
We aim to conducted a systematic review and meta-analysis of published RCTs (Randomized Controlled Trials, RCTs) to quantify the effects of CBT (Cognitive behavioral therapy, CBT), including both remote and in-person modalities, on anxiety, depressive symptoms, and QoL (Quality of Life, QoL) in people with PD (Parkinson's disease, PD).The systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Eight databases were systematically searched for existing RCTs of CBT in people of PD published in English or Chinese. Searches were updated to February 29, 2024. Methodological quality was appraised with the Cochrane Risk of Bias tool. A meta-analysis of comparative effects was performed using the Review Manager v.5.4 software.Results: 16 RCTs were included in the study. The studies involved a total of 682 participants, the mean age of participants ranged from 43 to 85. Depression scores of people in the CBT intervention group were significantly improved (SMD: -1.01, 95CI [-1.27, -0.74], P<0.001), the overall metaanalysis result showed that the CBT group had significant improvement in anxiety compared to the control group (SMD: -2.00, 95CI [-2.74, -1.26], P<0.001), results did not show a significant improvement in QoL in CBT group (SMD: -0.40, 95CI [-0.84, 0.04], P=0.08).This systematic review and meta-analysis provide evidence that CBT intervention significantly improved anxiety and depression in People of PD compared to the control group, whether through offline or remote intervention. No improvement effect of CBT intervention on the QoL of People of PD was found. In the future application of telemedicine, interdisciplinary interventions should be explored to improve the motor and non motor symptoms and QoL of People of PD.
Keywords: Anxiety, cognitive behavioral therapy, Depression, Meta, Parkinson's disease (32). 2.2 Search strategy PubMed, EMBASE, Cochrane Library, Web of Science (for relevant English literature)
Received: 03 Jun 2024; Accepted: 12 Aug 2025.
Copyright: © 2025 Yu, Wu, Liu, Han, Chen and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qi Guo, Shanghai University of Medicine and Health Sciences, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.