ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1539711
CITA GO-ON Study. A community based Multidomain Lifestyle Intervention to prevent cognitive decline. Protocol design and study progressrecruitment process
Provisionally accepted- 1Fundacion CITA Alzheimer, San Sebastian, Spain
- 2University of the Basque Country, Bilbao, Basque Country, Spain
- 3Osakidetza. Organización Sanitaria Integrada (OSI) Goierri-Urola Garaia, Pais Vasco, Spain
- 4Instituto de Investigación Sanitaria Biogipuzkoa, Donostia-San Sebastián, Spain
- 5NavarraBiomed, Pamplona, Navarre, Spain
- 6BCC Innovation, Technology Center for Gastronomy, Basque Culinary Center, Donostia-San Sebastián, Spain
- 7Basque Culinary Center, Faculty of Gastronomic Sciences, Mondragon Unibertsitatea, San Sebastian, Spain
- 8Achucarro Basque Center for Neuroscience, Leioa, Spain
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Growing research suggests that dementia is a complex disorder with multiple risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated that lifestyle interventions could confer cognitive benefits. Inspired by this, the GOIZ-ZAINDU (GZ) feasibility study adapted the FINGER approach to the Basque context. Building upon the GZ study, the CITA GO-ON trial aims to enhance and expand the evidence supporting dementia prevention through a multidomain intervention of risk factor management and resilience promotion. It is a two-year, population-based, randomized controlled trial to prevent cognitive decline in adults aged 60-85 years with Cardiovascular Risk Factors, Aging and Dementia (CAIDE) risk score ≥ 6, no dementia, and below-than-expected performance on at least one of three cognitive screening tests. Participants are randomized (1:1) to receive either Regular Health Advice (RHA) or a Multidomain Intervention (MD-Int) that encompasses cognitive training, socio-emotional skills, multicomponent physical exercise, nutritional and culinary intervention, and monitoring for cardiovascular risks, pharmacological drug mismanagement, and comorbidities. The primary outcome is the efficacy of the intervention to reduce the risk of cognitive decline measured by the global composite z-score of the modified Neuropsychological Test Battery over two years. The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. Blood samples and brain imaging will also be collected to evaluate the effects of the intervention on brain structure and plasma biomarkers. Recruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427). The final participant is expected to complete the last study visit by the autumn of 2026.The CITA GO-ON Study, as a part of the World-Wide FINGERS network, is designed to validate the efficacy of a multidomain lifestyle intervention for dementia prevention and contribute valuable data to inform public health strategies fostering healthy, active aging.The CITA GO-ON study was registered at ClinicalTrials.gov (NCT04840030) on 26 March 2021.
Keywords: cognitive impairment, dementia prevention, lifestyle, Multidomain intervention, Randomized trial Data collection MA: Data collection IR-E: Data collection
Received: 04 Dec 2024; Accepted: 26 May 2025.
Copyright: © 2025 Tainta, Ecay-Torres, Barandiaran, Estanga, Lopez, Altuna, Iriondo, Saldias, Garcia-Sebastian, Cañada, de Arriba, Reparaz-Escudero, Saez De Asteasu, Izquierdo, Balluerka, Gorostiaga, Ros, MARTINEZ, Domper, Gayoso, Arrizabalaga, Etxeberria, Torres, Alberdi, Capetillo-Zarate, Mateo-Abad, Vergara, Mar and Martinez-Lage. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mikel Tainta, Fundacion CITA Alzheimer, San Sebastian, 20009, Spain
Pablo Martinez-Lage, Fundacion CITA Alzheimer, San Sebastian, 20009, Spain
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