REVIEW article
Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1544605
This article is part of the Research TopicNeuroinflammation, Neurodegeneration, and Auditory-Vestibular DisordersView all 8 articles
Tittle:Research Progress of Platelets in Neurodegenerative Diseases
Provisionally accepted
- 1Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi, China
- 2Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, China
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Neurodegenerative disease(NDD) is a disease state characterized by the loss of neuronal cells in the brain and spinal cord, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). They have become a major challenge for the world's health system in the 21 st century, with an increasing incidence year by year, complex and diverse causes, and a lack of effective therapeutic . The brain and spinal cord are composed of neurons, and activated platelets are highly similar to neurons. The occurrence and development of these diseases are often accompanied by platelet activation, suggesting that platelets play an important role in the pathological process of NDDs. This article reviews the research progress of platelets in common NDDs, and elaborates on the mechanisms of platelets' involvement in NDDs and the use as a therapeutic option for NDDs to providing new ideas for the diagnosis and treatment of NDDs.
Keywords: platelets, Neurodegenerative Diseases, Neuroinflammation, Antiplatelet drugs, protein aggregation
Received: 13 Dec 2024; Accepted: 19 May 2025.
Copyright: © 2025 Lan, Ding, Yu and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chi Cheng, Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, Zunyi, China
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