MINI REVIEW article

Front. Aging Neurosci.

Sec. Alzheimer's Disease and Related Dementias

Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1547965

This article is part of the Research TopicAdvancing Early Alzheimer's Detection Through Multimodal Neuroimaging TechniquesView all 10 articles

Perspectives on Resting-State Functional Magnetic Resonance Imaging Research in Vascular Dementia

Provisionally accepted
Jinhuan YueJinhuan Yue1Peng WangPeng Wang2Xiang-Fa GuoXiang-Fa Guo3Zeyi WeiZeyi Wei3Kaiting HeKaiting He4Nuo LiNuo Li5Xiao-ling LiXiao-ling Li2*Qinhong ZhangQinhong Zhang6*Xiaoqing ZhouXiaoqing Zhou5*
  • 1Vitality University, Hayward, United States
  • 2First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
  • 3Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
  • 4Shandong University of Traditional Chinese Medicine, Jinan, China
  • 5Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, China
  • 6Heilongjiang University of Chinese Medicine, Harbin, China

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Vascular dementia (VD) is a severe cognitive impairment syndrome resulting from various cerebrovascular diseases and is one of the leading causes of senile dementia.In recent years, its incidence has been steadily increasing. Given the lack of specific treatments for VD, early detection, diagnosis, and intervention are critically important. This review examines the existing literature on resting-state functional magnetic resonance imaging (rs-fMRI) in the context of VD, with a focus on key metrics such as amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and functional connectivity (FC). By analyzing changes in brain functional activity in VD patients as observed through rs-fMRI, this study aims to provide essential imaging insights that could support and enhance clinical treatment strategies.

Keywords: Vascular Dementia, resting-state functional magnetic resonance imaging, Amplitude of low-frequency fluctuations, regional homogeneity, functional connectivity

Received: 19 Dec 2024; Accepted: 14 Jun 2025.

Copyright: © 2025 Yue, Wang, Guo, Wei, He, Li, Li, Zhang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Xiao-ling Li, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China
Qinhong Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
Xiaoqing Zhou, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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