REVIEW article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1558078
Exercise training exerts beneficial effects on Alzheimer's disease through multiple signaling pathways
Provisionally accepted
Jihe Kang1
Mei Liu1Qiang Yang1Xiangji Dang1Qun Li1Ting Wang1Bin Qiu1Yibao Zhang1
Xudong Guo1
Xiaoling Li1*
YAN LIU2*- 1Lanzhou University Second Hospital, Lanzhou, China
- 2School of Pharmacy, Lanzhou University, Lanzhou, Gansu Province, China
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Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive dysfunction that affects millions of people worldwide, placing a massive burden on families and economies. Exercise training can effectively reduce the prevalence of AD and alleviate its symptoms through the modulation of multiple signaling pathways involved in the pathophysiological process of AD, including the PI3K/Akt, Wnt/β-catenin, AMPK-related, MAPK, NF-κB, PINK1-PARKIN, JAK/STAT, and TREM2 signaling pathways. Different signaling pathways also crosstalk with each other through different targets to inhibit the formation of Amyloid β (Aβ) plaques, reduce the level of hyperphosphorylated tau protein, reduce apoptosis, relieve neuroinflammation, reduce autophagy dysfunction, and ultimately improve cognitive impairment in AD patients. This review summarizes the pathophysiological processes of AD affected by exercise training through different signaling pathways. We further provide a reference for the future development of new effective AD prevention and treatment targets to develop promising personalized, combined intervention strategies.
Keywords: exercise training, Alzheimer's disease, signaling pathway, Aβ metabolism, tau pathology, PI3K/Akt signaling pathway, Wnt/β-catenin signaling pathway
Received: 11 Feb 2025; Accepted: 05 May 2025.
Copyright: © 2025 Kang, Liu, Yang, Dang, Li, Wang, Qiu, Zhang, Guo, Li and LIU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoling Li, Lanzhou University Second Hospital, Lanzhou, China
YAN LIU, School of Pharmacy, Lanzhou University, Lanzhou, 730020, Gansu Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.