ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1569924
This article is part of the Research TopicThe Role of Neurotransmitters: From Normal Aging to Age-Related Diseases, Volume IIView all articles
Glutamate-associated Research in Parkinson's Disease: A Bibliometric Analysis
Provisionally accepted
- 1Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China
- 2Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
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Background: Parkinson's disease (PD) is a common neurodegenerative disease. As an important excitatory neurotransmitter, glutamate plays a key role in the nervous system. The imbalance of glutamate levels, the dysfunction of related receptors, and the abnormal activity of transporters are closely associated with the pathological process of PD. This study aims to explore the research hotspots, frontiers, and development directions of PD and glutamate.The relevant publications were obtained from the Web of Science. CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative evaluation. Results: A total of 2488 publications related to the research topic were included. From 2001 to 2024, the annual number of publications showed a fluctuating upward trend. The United States was a leader in this field, working closely with China, Italy, the United Kingdom, and France. Karolinska Institute was the most active institution. Core journals were mainly related to neuroscience, covering basic research, clinical applications, and pharmacology. Dr. Conn, P. Jeffrey was the most productive author. The paper "The functional anatomy of basal ganglia disorders" was the most co-cited literature. High-frequency keywords included PD, glutamate, basal ganglia, oxidative stress, dopamine (DA), neurons, alpha-synuclein (a-Syn), glutamate receptors, and synaptic plasticity. In recent years, a-Syn and neuroinflammation were the research topics with strong burst power. Conclusion: Research on PD and glutamate focused on countries with increasing aging. The collaboration of different countries and institutions was conducive to promoting the development of this field. The research hotspots included basal ganglia, oxidative stress, DA, neurons, a-Syn, glutamate receptors, and synaptic plasticity. a-Syn and neuroinflammation may be research directions in the future.
Keywords: Parkinson's disease, Glutamate, alpha-Synuclein, Neuroinflammation, synaptic plasticity
Received: 02 Feb 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Chen, Xie, Zhou and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fang Liu, Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China
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