SYSTEMATIC REVIEW article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1570428
This article is part of the Research TopicNew Strategies for Spinal Cord Injury and Immunotherapy Targeting Novel Programmed Death PathwaysView all 4 articles
Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004-2023)
Provisionally accepted
- 1Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- 2Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China
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Background Programmed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. Neurodegenerative diseases (NDDs) encompass a diverse array of neurological disorders that adversely impact the lives of millions of individuals globally. The current study discusses the impacts of PD-L1/PD-1 signaling on NDDs.Methods A comprehensive online search was conducted using the Web of Science Core Collection database (WOSCC), with a limited time frame set from 2004 to 2023. Data were analyzed with CiteSpace, VOSviewer and bibliometric package to explore trends in research output, key authors, institutions, journals, and thematic developments.This study analyzed 366 publications within the field of PD-L1/PD-1 and NDDs. During 2004 to 2023, there's an overall upward trajectory in the number of publications as the years progressed. The United States has a significant influence in this field, accounting for the highest number of publications. It also boasts the top two authors, six of the top ten journals, and four of the top five institutions in terms of article count. Keyword burst analysis identified EAE, Parkinson's disease, adaptive immunity, immune checkpoint blockade, and cerebrospinal fluid are research hotspots in recent years.This field has garnered increasing research attention, with the United States being the primary contributor. Recent studies have concentrated on the mechanisms through which PD-L1/PD-1 influences NDDs, and research into cerebrospinal fluid may persist as a focal point in the years to come. While the neuroprotective versus neurodegenerative effects of PD-L1/PD-1 signaling remain controversial, this pathway represents a promising diagnostic and therapeutic target for NDDs.
Keywords: PD-1, PD-L1, Neurodegenerative Diseases, bibliometric analysis, Citespace, VOSviewer
Received: 03 Feb 2025; Accepted: 12 May 2025.
Copyright: © 2025 Wu, Zhang, Cao, Xuan, Huai, Zhou and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Tian, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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